A5004673309- Child and Adolescent Psychosocial and Emotional Development
- Stress Responses and Cortisol
- Functional Brain Connectivity Studies
- Bullying, Victimization, and Aggression
- Memory and Neural Mechanisms
- Mental Health Research Topics
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Health, Environment, Cognitive Aging
- Neuroendocrine regulation and behavior
- Behavioral Health and Interventions
- Cognitive Abilities and Testing
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Identity, Memory, and Therapy
- Family Support in Illness
- Hearing Impairment and Communication
- Memory Processes and Influences
- Deception detection and forensic psychology
- Decision-Making and Behavioral Economics
- Attachment and Relationship Dynamics
- Resilience and Mental Health
- Advanced MRI Techniques and Applications
- Sex and Gender in Healthcare
- Autism Spectrum Disorder Research
Leiden University
2015-2024
Netherlands Institute for Neuroscience
2017
University of Amsterdam
2012-2014
Adolescence is a transition period characterized by heightened emotional reactivity, which for some sets the stage emerging depressive symptoms. Prior studies suggest that adolescent depression associated with deviant cortical and subcortical brain structure. Longitudinal are, however, currently scarce, but critical to detect adolescents are at risk developing
A fundamental task in neuroscience is to characterize the brain's developmental course. While replicable group-level models of structural brain development from childhood adulthood have recently been identified, we yet quantify and understand individual differences development. The present study examined inter-individual variability sex changes structure, as assessed by anatomical MRI, across ages 8.0-26.0 years 269 participants (149 females) with three time points data (807 scans), drawn...
Detailed descriptions of the development hippocampus promise to shed light on neural foundation memory and other cognitive functions, as well emergence major mental disorders. Hippocampus is a heterogeneous structure with characterized internal complexity, but its distinct subregions in humans has remained poorly described. We analyzed magnetic resonance imaging (MRI) data from large longitudinal sample (270 participants, 678 scans) using an automated segmentation tool mixed models delineate...
Although male brains have consistently reported to be 8–10% larger than female brains, it remains not well understood whether there are differences between sexes (average or variance) in developmental trajectories. Furthermore, if sex average brain growth variance observed, is unknown these behavioral relevance. The present longitudinal study aimed unravel effects cortical structure, development, and variance, relation the development of educationally relevant cognitive domains executive...
Upon recall, a memory can enter labile state in which it requires new protein synthesis to restabilize. This two-phased reconsolidation process raises the prospect directly target excessive fear as opposed formation of inhibitory following extinction training. In our previous studies, we convincingly demonstrated that 40 mg propranolol HCl administration before or after reactivation eliminated emotional expression indexed by potentiated startle reflex. To apply this procedure clinical...
Cross-sectional studies report relations between externalizing behavior and structural abnormalities in cortical thickness of prefrontal regions volume reductions subcortical regions. To understand how these associations emerge develop, longitudinal designs are pivotal.In the current study, a community sample children, adolescents young adults (N = 271) underwent magnetic resonance imaging (MRI) three biennial waves (680 scans). At each wave, aspects were assessed with parent-reported...
This multimethod multisample longitudinal study examined how neurological substrates associated with goal directedness and information seeking are related to adolescents’ identity. Self‐reported data on goal‐directedness were collected across three biannual waves in Study 1. Identity was measured one wave later. 1 design measurements repeated 2 extended structural brain (nucleus accumbens [NAcc] prefrontal cortex gray matter volume [PFC]), waves. included 497 adolescents ( M age T1 = 13.03...
This study provides a comprehensive picture of three core elements (Intentions, Desires, Beliefs) Theory Mind (ToM) in young children with autism spectrum disorder (ASD, n = 63, Mage 55 months) and typically developing (TD, 69, 54 months). Outcomes showed that ASD TD understood intentional actions equally well. Yet, lacked the social interest to share intentions. Additionally, had more difficulties understanding others' desires beliefs compared their peers. It is discussed whether ToM delay...
Children and adolescents with Autism Spectrum Disorder (ASD) often show comorbid emotional behavior problems. The aim of this longitudinal study is to examine the relation between emotion control (i.e., negative emotionality, awareness, worry/rumination) development internalizing externalizing Boys without ASD (N = 157; age 9-15) were followed over a period 1.5 years (3 waves). We found that baseline levels worry/rumination was specific predictor later problems for boys ASD. Furthermore,...
Psychophysiological research on emotion utilizes various physiological response measures to index activation of the defense system. Here we tested 1) whether acoustic startle reflex (ASR), skin conductance (SCR) and heart rate (HR) elicited by highly arousing stimuli specifically reflect a defensive state 2) relation between resting variability (HRV) affective responding. In within-subject design, participants viewed film clips with positive, negative neutral content. contrast SCR HR, show...
Risk taking is a multidimensional construct. It currently unclear which aspects of risk‐taking change most during adolescence and if/how sex hormones contribute to tendencies. This study applied longitudinal design with three time‐points, separated by 2 years, in participants aged 8–29 years (670 observations). The Balloon Analogue Task, delay discounting task, various self‐report questionnaires were administered, measure risk taking. Longitudinal analyses demonstrated mostly nonlinear...
Adolescence is a sensitive period for socio-cultural processing and vast literature has established that adolescents are exceptionally attuned to the social context. Theoretical accounts posit reward of interactions plays large role in adolescent sensitivity Yet, date it unclear how develops across adolescence young adulthood whether there gender differences. The present cross sectional study (N = 271 participants, age 11-28 years) examined effects self-reported different types rewards. In...
Research on mental health has traditionally separated the study of illbeing—disorder and problems—and wellbeing—life satisfaction positive affect. While previous reviews studies primarily employing self-report scales indicate that illbeing wellbeing are distinct yet interconnected constructs, a deeper examination their relationship is lacking. This perspective article from PROMENTA Center offers review synthesis findings joint nature across multiple levels analysis. Adopting an...
The present study examined developmental and gender differences in sensitivity to peer rejection across the transition into adolescence by examining beat-by-beat heart rate responses. Children between ages of 8 14 years were presented with unfamiliar faces age-matched peers asked predict whether they would be liked other person. Their prediction was followed feedback indicating that had accepted or rejected them. Results revealed cardiac slowing unexpected 11- 14-year-olds. response most...
Early adulthood has long been recognized as a potential turning point for the development of antisocial behavior, due to changes in social contexts and ongoing psychological neurobiological maturation. However, it remains unclear how different developmental trajectories their neural underpinnings, individual differences psychopathic traits may help explain distinct outcomes individuals who persist or desist from behavior early - such they respond others contexts. Therefore, current study,...
Although fear-learning research has tended to focus on typical responses, there is substantial individual variation in response threat. Here, we investigated how personality related variability associative fear learning. We used multilevel growth curve modeling examine the unique and interactive effects of Stress Reaction (SR) Harmavoidance (HA; Multidimensional Personality Questionnaire scales) their corresponding higher-order factors differential conditioning ( n = 225) extinction 109;...
In hearing adolescents, emotions play important roles in the development of bullying and victimization. Yet, it is unclear whether this also applies to adolescents who are deaf or hard (DHH). The present study examines longitudinal associations anger, fear, guilt, shame with bullying/victimization DHH adolescents. Overall, 80 227 (Mage = 11.7; 103 males) completed self-reports on two occasions a 9-month interval. Outcomes show that reported fewer behaviors, but more victimization compared...
Prior research has implicated the medial and lateral prefrontal cortex (PFC) in processing evaluations from perspective of self (self-traits) others (peer feedback), suggesting that these areas form a neural substrate serves an intertwined function monitoring relation to others. To test this possibility, we examined activation overlap PFC after self- other-informed evaluations. Young adults (age range 18-30-yrs, n = 40) performed two fMRI tasks. The self-concept task involved rating whether...
Performance on cognitive control tasks deteriorates when are performed together with other tasks, that is, if simultaneous is required. Surprisingly, this also observed preceded by sequential The typical explanation for the latter finding previous acts of deplete a common resource, just like muscle becomes fatigued after repeated usage. An alternative explanation, however, reduce motivation to match allocated resources required resources. In paper we formalize these and accounts, show they...