A5052099759- HIV/AIDS Research and Interventions
- Adolescent Sexual and Reproductive Health
- Adolescent and Pediatric Healthcare
- HIV Research and Treatment
- Neonatal and fetal brain pathology
- HIV/AIDS drug development and treatment
- HIV/AIDS Impact and Responses
- Child and Adolescent Psychosocial and Emotional Development
- Infant Development and Preterm Care
- Counseling Practices and Supervision
- Maternal Mental Health During Pregnancy and Postpartum
- HIV-related health complications and treatments
- Mental Health Treatment and Access
- Pneumocystis jirovecii pneumonia detection and treatment
- Psychiatric care and mental health services
- Autism Spectrum Disorder Research
- Community Health and Development
- Family Caregiving in Mental Illness
- Health Policy Implementation Science
- Family Support in Illness
- Cervical Cancer and HPV Research
- Mental Health and Patient Involvement
- Epilepsy research and treatment
- Viral-associated cancers and disorders
- Migration, Health and Trauma
Botswana-Baylor Children's Clinical Center of Excellence
2014-2023
Botswana Harvard AIDS Institute Partnership
2021
Baylor University
2015
Abstract: Pill counts with calculated adherence percentages are used in many settings to monitor adherence, but can be undermined by patients discarding pills hide nonadherence. suggesting that >100% of prescribed doses were taken signal “pill dumping.” We defined “overadherence” among a cohort 300 HIV-infected adolescents as having greater than one-third pill during year follow-up. Apparent overadherence was more common those virologic failure suppressed viral loads (33% vs 13%, χ 2 P =...
Levels of adherence to HIV treatment are lower among adolescents compared with older and younger individuals receiving similar therapies. We purposely sampled the most least adherent from a 300-adolescent longitudinal study in Gaborone, Botswana. Multiple objective subjective measures were available participants selected based on sustained patterns either excellent or poor over one-year period. Focus group discussions (FGD) in-depth interviews (IDI) conducted subset their caregivers goal...
Abstract Background Depression and suicidal behavior are the main causes of disability morbidity, especially in adolescents living with HIV (ALWHIV). Data regarding these lacking Botswana, a country predominantly youthful population ranked among top four world most affected by HIV. Therefore, present study aimed to estimate prevalence depression explore their associated factors Botswana ALWHIV. Methods Responses were obtained from 622 ALWHIV using DSM-5 Mini-International Neuropsychiatric...
Globally, mental health problems have been reported to be more common in youth living with HIV (YLWH) than the general population, but routine screening is rarely done high-volume clinics. In 2019, YLWH a large clinic Botswana were screened using Generalized Anxiety Scale-7 (GAD-7) and Patient Health Questionnaire-9 (PHQ-9) pilot standard-of-care programme. Two-way ANOVA was used describe effects of age group (12–<16, 16–<20 20–25 years old) sex on GAD-7 PHQ-9 scores. Chi-square statistics...
leftover opioid doses after day 3 to treat their acute pain for more than 2 additional weeks.Discussion | Our findings showed the potential mismatch between amounts of opioids prescribed/dispensed and used following minor pediatric ambulatory procedures associated with pain.Most children received less 50% prescribed because parents quickly tapered opioids, switched nonopioids, or discontinued analgesics during first few postprocedure days.This left a considerable amount unused in homes who...
Introduction Neurodevelopmental delays and cognitive impairments are common in youth living with HIV. Unfortunately, resource-limited settings, where HIV infection impacts millions of children, neurodevelopmental disorders commonly go undetected because a lack appropriate assessment instruments local expertise. Here, we present protocol to culturally adapt validate the Penn Computerized Neurocognitive Battery (PennCNB) examine its validity for detecting both advanced subtle problems among...
Youth living with HIV (YLWH) have higher rates of common mental disorders (CMDs) when compared HIV-negative youth. We adapted the Friendship Bench to create a problem solving-based counselling intervention in Botswana delivered by near peer youth lay counsellors for YLWH called Safe Haven. In August 2020, and from June 2021, we conducted 22 semistructured interviews aged 13-25 years mild-to-moderate symptoms CMDs. Two independent coders carried out an inductive thematic analysis transcribed...
Study Objectives Psychosocial factors such as outcome expectancy, perceived stigma, socio-emotional support, consideration of future consequences, and psychological reactance likely influence adolescent adherence to antiretroviral treatments. Culturally-adapted validated tools for measuring these in African adolescents are lacking. We aimed identify culturally-specific importance establishing local construct validity Botswana. Methods Using in-depth interviews 34 HIV+ adolescents, we...
High mortality among adolescents with HIV reflects delays and failures in the care cascade. We sought to elucidate critical missed opportunities barriers hospitalized at Botswana's tertiary referral hospital. enrolled all HIV-infected (aged 10–19 years) any diagnosis other than pregnancy from July 2015 January 2016. Medical records were reviewed for clinical variables past engagement care. Semi-structured interviews of (when feasible) their caregivers explored Twenty-one eligible identified...
Children born to mothers infected with the human immunodeficiency virus (HIV) during pregnancy experience increased risk of neurocognitive impairment. In Botswana, HIV infection is common among youth, but standardized cognitive screening limited. The Penn Computerized Neurocognitive Battery (PennCNB), a tool that streamlines evaluation functioning, was culturally adapted for use youth in this high-burden, low-resource setting. present study examined structural validity PennCNB. A cohort...
Abstract Purpose The purpose of this study was to determine whether diary‐driven adjustment Medication Event Monitoring System (MEMS) data based on Supporting Information strengthens the relationship between measured antiretroviral medication adherence and plasma HIV viral load (VL). Methods HIV+ adolescents treatment were monitored with MEMS for 30 days preceding a VL measurement. primary outcome ≥ 400 copies/mL. Handwritten diaries used comprehensively record deviations from recommended...
Cervical cancer burden and prevalence of precursor lesions is unknown among young women living with HIV in high settings. Current cervical screening guidelines resource-limited settings typically exclude adolescents women. After observing two cases advanced perinatally acquired HIV, a pilot programme was established Botswana.To compare the abnormalities aged 30-49 years, regardless status.We conducted cross-sectional study 30-49-year-old who had visual inspection acetic acid through Botswana...
Youth Lay Counsellors deserve comprehensive
<h3>Aims</h3> When implementing interventions for adolescents, specific adolescent friendly adaptation from adult is vital. The Friendship Bench a lay counselor community therapy model that has been shown to have high efficacy in populations with counselors Zimbabwe and other communities. Our objective was understand the overall mental health needs necessary adaptations based work adolescents Botswana. <h3>Methods</h3> We used theory of change activities during stakeholder meetings discuss...
Human immunodeficiency virus (HIV) infection is prevalent among children and adolescents in Botswana, but standardized neurocognitive testing limited. The Penn Computerized Neurocognitive Battery (PennCNB) attempts to streamline evaluation of functioning has been culturally adapted for use youth this high-burden, low-resource setting. However, its reliability across measurements (i.e., test-retest reliability) unknown. This study examined the PennCNB 65 school-age (age 7-17) living with HIV...