A5004608187- Effects of Radiation Exposure
- Genomics, phytochemicals, and oxidative stress
- Radiation Effects and Dosimetry
- Lymphoma Diagnosis and Treatment
- Phytochemicals and Medicinal Plants
- Plant Toxicity and Pharmacological Properties
- Natural Antidiabetic Agents Studies
- Phytochemical and Pharmacological Studies
- Silymarin and Mushroom Poisoning
- Drug-Induced Hepatotoxicity and Protection
- Essential Oils and Antimicrobial Activity
- GABA and Rice Research
- Hydrogen's biological and therapeutic effects
- Immune Cell Function and Interaction
- Medicinal plant effects and applications
- Radiation Therapy and Dosimetry
- Monoclonal and Polyclonal Antibodies Research
- Cancer therapeutics and mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
- Synthesis and Biological Evaluation
- Plant Genetic and Mutation Studies
- Radiopharmaceutical Chemistry and Applications
- Medicinal Plants and Neuroprotection
- Carcinogens and Genotoxicity Assessment
- Glutathione Transferases and Polymorphisms
Jiwaji University
2024
Institute of Nuclear Medicine & Allied Sciences
2011-2022
Ministry of Defence
2017-2018
Defence Research and Development Organisation
2010-2016
Institute for Medical Research
2008
Cleveland Clinic Lerner College of Medicine
2006-2008
Roswell Park Comprehensive Cancer Center
2008
Cleveland BioLabs (United States)
2008
Sanford Burnham Prebys Medical Discovery Institute
2008
Cleveland Clinic
2005-2007
The toxicity of ionizing radiation is associated with massive apoptosis in radiosensitive organs. Here, we investigate whether a drug that activates signaling mechanism used by tumor cells to suppress can protect healthy from the harmful effects radiation. We studied CBLB502, polypeptide derived Salmonella flagellin binds Toll-like receptor 5 (TLR5) and nuclear factor–κB signaling. A single injection CBLB502 before lethal total-body irradiation protected mice both gastrointestinal...
Terminalia chebula Gertn. (Combetraceae) is an important herbal drug in Ayurvedic pharmacopea. In the present study, a 95% ethanolic extract of T. (fruit) (TC extract), which was chemically characterized on basis chebuloside II as marker, investigated for hepatoprotective activity against anti-tuberculosis (anti-TB) drug-induced toxicity. TC found to prevent hepatotoxicity caused by administration rifampicin (RIF), isoniazid (INH) and pyrazinamide (PZA) (in combination) sub-chronic mode (12...
Fourteen saxicolous lichens from trans-Himalayan Ladakh region were identified by morpho-anatomical and chemical characteristics. The n-hexane, methanol water extracts of the evaluated for their antioxidant capacities. lichen showing high capacities rich phenolic content further investigated to determine cytotoxic activity on human HepG2 RKO carcinoma cell lines. ferric reducing power (FRAP), 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS),...
The present report showed the hepatoprotective property of a 50% hydroalcoholic extract fruits Emblica officinalis (fruit) (EO-50) against antituberculosis (anti-TB) drugs-induced hepatic injury. biochemical manifestations hepatotoxicity induced by rifampicin (RIF), isoniazid (INH) and pyrazinamide (PZA), either given alone or in combination were evaluated. In vitro studies done on suspension cultures rat hepatocytes while sub-acute carried out rats. activity EO-50 was found to be due its...
Rituximab has been revolutionized and validated CD20 targeting monoclonal antibody. Although, it is widely used for lymphoma therapy many patients have benefited. However significant numbers of are refractory or developed resistance to current therapies due low level expression and/or availability on cells surface. Thus development novel anti-CD20 mAbs with great cell killing ability enhance levels surface can potentially exploit therapy. In this scenario, we summarizing the recently against...
The freshwater alga Spirogyra porticalis (Muell.) Cleve, a filamentous charophyte, collected from the Indian trans-Himalayan cold desert, was identified on basis of morpho-anatomical characters. Extracts this were made using solvents varying polarity viz. n-hexane, acetonitrile, methanol and water. antioxidant capacities phenolic profile extracts estimated. extract showing highest capacity rich attributes further investigated phytochemical profiling conducted by gas chromatography-mass...
The whole extract of the fresh berries Hippophae rhamnoides L. (RH-3), which has been reported to provide protection mice, various tissues, cells and cell organelles against lethal irradiation, was further investigated for its effects on mitochondria isolated from mouse liver. Superoxide anion, reduced (GSH) oxidized glutathione (GSSG) levels, NADH-ubiquinone oxidoreductase (complex I), NADH-cytochrome c I/II), succinate-cytochrome II/III), mitochondrial membrane potential (MMP), lipid...
Background The sensitivity of human Burkitt's lymphoma cells to rituximab (Rtx) and tositumomab (Tst) was assessed on expressing different levels CD20 surface. Cells that harbor low may resists against therapeutics response CD20-specific antibodies. We postulated that, radiation-induced modulation surface play a crucial central role in determining the relative efficacy treating disease. Here, we examined γ-radiation-induced expression Burkitt cell line 'Daudi' relation differential with...
Silymarin, a purified extract of seeds Silybum marianum L. and well known for its hepatoprotective abilities, has been evaluated inherent utility as radioprotective agent. A fraction (INM-7035) was authenticated by characterizing the percentage composition silybin B (39.9% 57.4%). Free radical scavenging activities INM-7035 against superoxide radicals (>68%), hydroxyl (>33.75%), DPPH (67.2%), ABTS (32.4%) were also evaluated. The chelated (>30%) ferrous ions, thereby able to...
The present study is the first report of radiomodulatory effects Psoralea corylifolia Linn. extract (IBG-RA-26) prepared from P. was chemically analysed by HPLC, LC-MS/MS and NMR. total polyphenolic content IBG-RA-26 0.287 mg/ml quercetin equivalents. exhibited a dose-dependent increase in 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity. It comparable (> 50%) site-specific non-site-specific hydroxyl activity higher concentration ranges (500-1000 microg/ml), while at lower...
Low LET Ionizing radiation is known to alter intracellular redox balance by inducing free radical generation, which may cause oxidative modification of various cellular biomolecules. The extent biomolecule-modifications/ damages and changes in vital processes (viz. homeostasis, inter-/intra-cellular signaling, mitochondrial physiology/dynamics antioxidant defence systems) are crucial turn determine fate cells.In the present study, we expended TLR expressing (normal/ transformed) null cells;...
Recent reports demonstrated the role of silymarin as a cytoprotective agent for normal cells against ionizing or non-ionizing (UV) radiation, and in inhibiting chemically initiated promoted carcinogenesis several malignancies, such skin prostate cancers. Silymarin is plant flavonoid obtained from milk thistle; main active principles thistle are silybin (silibinin), sylichrisitin silydianin, commonly referred silymarin. In present study, we aimed to investigate radiation modulatory effects on...
Technetium-99m (99mTc) is extensively used in nuclear medicine, mostly to label radiopharmaceuticals and radio diagnostics. In the present study, we directly radiolabeled mannan with 99mTc by using Tin(II) Chloride Dihydrate (SnCl2·2H2O) as a reducing agent. Mannan, TLR agonist complex carbohydrate identified potential modulator of biological effects ionizing radiation, both vitro vivo, our laboratory. Under vivo conditions modulates radiation response when administered through either oral...
.Management of radiation-induced reactive oxygen/nitrogen species requires a holistic approach to mitigate the deleterious effects free radicals. Flora Himalayas, which prevails under extreme climatic conditions, has been explored for its potential utility develop radioprotective drugs. The Himalayan high altitude medicinal plant, Podophyllum hexandrum Royle, was selected on basis unique properties, and novel fractionated nonpolar extract (REC-2003) prepared evaluated efficacy, in vitro as...