A5058159365- Pediatric Pain Management Techniques
- Stress Responses and Cortisol
- Anesthesia and Neurotoxicity Research
- Neuroendocrine regulation and behavior
- Ion channel regulation and function
- Infant Development and Preterm Care
- Neuroscience and Neuropharmacology Research
- Intensive Care Unit Cognitive Disorders
- Cancer, Stress, Anesthesia, and Immune Response
- Memory and Neural Mechanisms
- Neuroscience of respiration and sleep
- Neurotransmitter Receptor Influence on Behavior
- Tryptophan and brain disorders
- Receptor Mechanisms and Signaling
University of Toronto
2015
Georgia State University
2013-2015
University of Minnesota
2015
Institute of Pharmacology
2015
University of Alberta
2015
Novem (Netherlands)
2015
Women and Children’s Health Research Institute
2015
Drugs acting on μ-opioid receptors (MORs) are widely used as analgesics but present side effects including life-threatening respiratory depression. MORs G-protein-coupled inhibiting neuronal activity through calcium channels, adenylyl cyclase, and/or G-protein-gated inwardly rectifying potassium (GIRK) channels. The pathways underlying MOR-dependent inhibition of rhythmic breathing unknown.By using a combination genetic, pharmacological, and physiological tools in rodents vivo, the authors...
G-protein-gated inwardly rectifying K + (GIRK/Kir3) channel activation underlies key physiological effects of opioids, including analgesia and dependence. GIRK has also been implicated in the opioid-induced inhibition midbrain GABA neurons consequent disinhibition dopamine (DA) ventral tegmental area (VTA). Drug-induced VTA DA linked to reward-related behaviors motor activation. Here, we demonstrate that mouse express a formed by GIRK1 GIRK2 subunits. Nevertheless, neither constitutive...
Approximately 500,000 infants are born prematurely each year in the United States. These typically require an extensive stay neonatal intensive care unit (NICU), where they experience on average 14 painful and invasive procedures day. procedures, including repeated heel lance, insertion of intravenous lines, respiratory gastric suctioning, result inflammatory response, inducing pain stress newborn. Remarkably, majority these performed complete absence pre- or post-emptive analgesics. Recent...
Less than 60% of infants undergoing invasive procedures in the neonatal intensive care unit receive analgesic therapy. These show long-term decreases pain sensitivity and cortisol reactivity. In rats, we have previously shown that inflammatory experienced on day birth significantly adult somatosensory thresholds responses to anxiety- stress-provoking stimuli. changes stress responsiveness are accompanied by two-fold increases central met-enkephalin β-endorphin expression. However, time...
Previous studies in rats have established that inflammatory pain experienced on the day of birth (P0) decreases sensitivity to acute noxious, anxiety- and stress-provoking stimuli. However, date, impact early-life adult responses chronic stress is not known. Further, ability morphine, administered at time injury, mitigate changes behavioral hormonal or stressors has been examined. P0 male female Sprague-Dawley rat pups were given an intraplantar injection 1% carrageenan handled identical...