A5102938826- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Inflammasome and immune disorders
- Medicinal Plants and Neuroprotection
- Heme Oxygenase-1 and Carbon Monoxide
- Cannabis and Cannabinoid Research
- Autophagy in Disease and Therapy
- Alzheimer's disease research and treatments
- Inflammatory mediators and NSAID effects
- Neurological Disorders and Treatments
- Cancer, Lipids, and Metabolism
- Sirtuins and Resveratrol in Medicine
- Biochemical effects in animals
- Adenosine and Purinergic Signaling
- Cancer-related cognitive impairment studies
- Medicinal Plants and Bioactive Compounds
- Peroxisome Proliferator-Activated Receptors
- Ovarian cancer diagnosis and treatment
- Olfactory and Sensory Function Studies
- Calcium signaling and nucleotide metabolism
- Nicotinic Acetylcholine Receptors Study
Griffith University
2016-2025
Manipal Academy of Higher Education
2016-2023
Institute of Pharmacology
2015
University of Illinois Chicago
2011-2014
Queen's University
2012
University of Minnesota
2010-2011
University of Pittsburgh
2007
The University of Texas at Austin
2000
St James's University Hospital
1997
We sought to develop a therapeutic agent that would permit prolongation of survival in rats subjected lethal hemorrhagic shock (HS), even the absence resuscitation with asanguinous fluids or blood.We synthesized series compounds consist electron scavenger and superoxide dismutase mimic, 4-amino-2,2,6,6-tetramethylpiperidine-N-oxyl (4-NH2-TEMPO), conjugated fragments analogs membrane-active cyclopeptide antibiotic, gramicidin S. Using an vivo assay, wherein isolated intestinal segments were...
Enhanced glutamatergic neurotransmission in dopamine (DA) neurons of the ventral tegmental area (VTA), triggered by a single cocaine injection, represents an early adaptation linked to more enduring effects abused drugs that characterize addiction. Here, we examined impact vivo exposure on metabotropic inhibitory signaling involving G-protein-gated inwardly rectifying K(+) (Girk) channels VTA DA neurons. Somatodendritic Girk currents evoked GABA(B) receptor (GABA(B)R) agonist baclofen were...
G-protein-gated inwardly rectifying K + (GIRK/Kir3) channel activation underlies key physiological effects of opioids, including analgesia and dependence. GIRK has also been implicated in the opioid-induced inhibition midbrain GABA neurons consequent disinhibition dopamine (DA) ventral tegmental area (VTA). Drug-induced VTA DA linked to reward-related behaviors motor activation. Here, we demonstrate that mouse express a formed by GIRK1 GIRK2 subunits. Nevertheless, neither constitutive...
Abstract Increased effectiveness and decreasing toxicity are prime objectives in drug research. Overwhelming evidence suggests the use of appropriate combination therapy for better efficacy drugs owing to their synergistic profile. Dietary active constituents play a major role health outcomes. Therefore, it is possible increase by combining contemporary medication with natural/semi-synthetic constituents. One such dietary constituent, caffeic acid (CA), by-product shikimate pathway plants...
J. Neurochem. (2010) 114 , 1487–1497. Abstract Mice lacking the Girk2 subunit of G protein‐gated inwardly rectifying K + (Girk) channels exhibit dopamine‐dependent hyperactivity and elevated responses to drugs that stimulate dopamine neurotransmission. The phenotypes seen in − / mice could reflect increased intrinsic excitability or diminished inhibitory feedback midbrain neurons, secondary adaptations triggered by ablation. We addressed these possibilities evaluating Girk behavioral,...
Neuroinflammation plays an important role in the pathophysiology of Alzheimer's disease. Neurokinin substance P is a key mediator which modulates neuroinflammation through neurokinin receptor. Involvement disease still plausible and various controversies exist this hypothesis. Preventing deleterious effects using N-acetyl-L-tryptophan, antagonist could be promising therapeutic strategy. This study was aimed to evaluate effect N-acetyl-L-tryptophan on aluminum induced spatial memory...
Caffeine (CAF) and polyphenolic compounds like caffeic acid (CA), chlorogenic ferulic are commonly consumed through beverages food. These constituents modulate immune system impact the systemic inflammatory pathways. This study explored modulatory effect of CA + CAF on behavior lipopolysaccharide (LPS) – induced neuroinflammation in mice. An array behavioral tests suggest that (15 mg/kg) (10 mg/kg 5 express anxiolytic-like properties. Systemic administration LPS (1.5 profound immobility,...