A5061633604- Glioma Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Hip and Femur Fractures
- Trauma and Emergency Care Studies
- Cerebral Venous Sinus Thrombosis
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Lipid Membrane Structure and Behavior
- Neuroscience and Neuropharmacology Research
- Brain Metastases and Treatment
- Global Health and Surgery
- Traumatic Brain Injury and Neurovascular Disturbances
- Cellular transport and secretion
- Cerebrospinal fluid and hydrocephalus
- COVID-19 and healthcare impacts
- Psychosomatic Disorders and Their Treatments
- Epilepsy research and treatment
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Healthcare cost, quality, practices
- Trigeminal Neuralgia and Treatments
- Cardiac Arrest and Resuscitation
- Neuroinflammation and Neurodegeneration Mechanisms
- Neonatal and fetal brain pathology
- Amyotrophic Lateral Sclerosis Research
- Anesthesia and Neurotoxicity Research
University of Cambridge
2023-2025
Cambridge University Hospitals NHS Foundation Trust
2024
National Institute for Health Research
2024
University of Birmingham
2024
Addenbrooke's Hospital
2024
University of Edinburgh
2021-2023
Imperial College London
2022
Traumatic brain injury (TBI) is a major public health challenge in India but there lack of high-quality data on its clinical characteristics and outcomes. We aimed to describe the TBI population tertiary care center India, identify predictors inpatient mortality, assess performance existing prognostic tools. conducted prospective observational cohort study patients admitted high-volume Vellore, after between 2013 2019. identified 3172 (2667 males, 84%) (median age = 34 years [IQR 23-48])....
Abstract Background Chronic subdural haematoma (CSDH) drainage is a common neurosurgical procedure. CSDHs cause excess mortality, which exacerbated by frailty. Sarcopenia contributes to frailty – its key component, low muscle mass, can be assessed using cross‐sectional imaging. We aimed examine the prognostic role of temporal thickness (TMT) measured from preoperative computed tomography head scans among patients undergoing surgical CSDH drainage. Methods retrospectively identified all who...
15-30% of primary cancers metastasise to the brain. Of these, 10-25% involve posterior fossa. It remains unclear whether patients undergoing resection for infratentorial brain metastases experience poorer prognosis than those with supratentorial lesions. We compare post-operative outcomes these two groups.We searched electronic health records all at our regional neurosurgical centre between February 2014 and August 2019. Clinical data was collected on 85 consecutive (61 supratentorial, 24...
Abstract Introduction Surgical care in first‐referral hospitals (FRHs) low‐ and middle‐income countries (LMICs) is poorly characterized. Inguinal hernia repair can act as a good tracer condition. This study aimed to evaluate the variation across different hospital types LMICs. Methods We conducted secondary analysis of an international prospective cohort surgery. Data was collected from consecutive patients undergoing primary inguinal between 30 January May 21, 2023. characterized LMICs,...
Abstract Dynamin-1 is a large GTPase with an obligatory role in synaptic vesicle endocytosis at mammalian nerve terminals. Heterozygous missense mutations the dynamin-1 gene ( DNM1 ) cause novel form of epileptic encephalopathy, pathogenic clustering within regions required for its essential activity. We reveal most prevalent mutation, R237W, disrupts enzyme activity and when overexpressed central neurons. To determine how this mutation impacted cell, circuit behavioural function, we...
the Clavien-Dindo classification and these data were collected at 30 days after surgery 14 .To comprehensively evaluate postoperative complications, surgical-site infection rates reoperation (mapped to surgical approach use of mesh) also surgery. Data managementData stored online using a secure server running Research Electronic Capture (REDCap) web application 15 .The service was managed by Global Surgery REDCap system hosted University Birmingham, UK.Its security governed policies...
Benign Epilepsy with Centro-Temporal Spikes (BECTS) is a pediatric epilepsy typically good seizure control. Although BECTS may increase patients' risk of developing neurological comorbidities, their clinical care and short-term outcomes are poorly quantified.We retrospectively assessed adherence to National Institute for Health Care Excellence (NICE) guidelines relating specialist referral, electroencephalogram (EEG) conduct annual review in the patients BECTS, measured seizure,...
Abstract Background Traumatic brain injury (TBI) is a common neurosurgical emergency but its epidemiological and clinical characteristics vary across country income levels. High-quality TBI data from low lower-middle countries are required to inform trials public policy in these settings. Methods We performed prospective cohort study of patients admitted high-volume tertiary hospital Vellore, India following between 2013 2019. collected on patient measured their outcomes using the Glasgow...
Abstract Pathogenic heterozygous missense mutations in the DNM1 gene result a novel form of epileptic encephalopathy. encodes for large GTPase dynamin-1, an enzyme with obligatory role endocytosis synaptic vesicles (SVs) at mammalian nerve terminals. cluster within regions required its essential activity, implicating disruption this activity as being central to We reveal that most prevalent pathogenic mutation , R237W, disrupts dynamin-1 and SV when overexpressed neurons. To determine how...
Abstract Background We present the clinical, MRI and CT findings in a case of new mitochondrial genome mutation (tRNA arginine gene), characterized by brain calcifications which are indicative Kearns–Sayre syndrome (KSS). Some radiological features resembled those Fahr’s disease (affecting PDGFRB gene). Case presentation A 36-year-old male presented some typical clinical KSS, including onset before 20 years age, pigmentary retinopathy, progressive external ophthalmoplegia ptosis. However,...
Abstract Purpose 15–30% of primary cancers metastasise to the brain. Of these, 10–25% involve posterior fossa. It remains unclear whether patients undergoing resection for infratentorial brain metastases experience poorer prognosis than those with supratentorial lesions. We aim compare post-operative outcomes these two groups. Methods searched electronic health records all at our regional neurosurgical centre between February 2014 and August 2019. Demographic clinical data was collected on...
With an additional 23,300 neurosurgeons needed to address the over 5 million unmet essential neurosurgical cases presenting in low- and middle-income countries (LMICs) each year, a global approach safe effective neurosurgery is essential. Global neurosurgery, defined as “an area for study, research, practice, advocacy that places priority on improving health outcomes achieving equity” patients worldwide, has delivered tangible progress this challenge past decade. The movement facilitated...