A5070044945- Chronic Lymphocytic Leukemia Research
- Frailty in Older Adults
- Genetic factors in colorectal cancer
- Cancer-related Molecular Pathways
- Nutrition and Health in Aging
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Cancer survivorship and care
- Occupational and environmental lung diseases
- Cancer Immunotherapy and Biomarkers
- Linguistics and Discourse Analysis
- DNA Repair Mechanisms
- Palliative Care and End-of-Life Issues
- Viral-associated cancers and disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Polyomavirus and related diseases
- Vasculitis and related conditions
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Multiple Myeloma Research and Treatments
- Renal Transplantation Outcomes and Treatments
- Multiple and Secondary Primary Cancers
- Immunodeficiency and Autoimmune Disorders
- CNS Lymphoma Diagnosis and Treatment
Université Catholique de Lille
2022-2024
Hôpital Saint-Vincent-de-Paul
2024
Centre Hospitalier Universitaire de Rennes
2018-2022
Institut Jules Bordet
2018-2021
Palmetto Hematology Oncology
2019
Université Libre de Bruxelles
2019
Goodpasture Syndrome (GS) is an autoimmune disease caused by the development of auto-antibodies against Glomerular Basement Membrane (GBM). Linear deposit immunoglobulins G on GBM detected immunofluorescence analysis renal biopsies a GS pathognomonic finding. commonly monophasic and its incidence 1.6 case per million year. This report describes discusses 40-year-old woman who one year after allograft kidney transplant, presented with acute pulmonary symptoms GS, leading to graft dysfunction,...
Age-related genetic changes in lymphocyte subsets are not currently well documented. BACH2 is a transcription factor that plays an important role immune-mediated homeostasis by tightly regulating PRDM1 expression both B-cells and T-cells. gene highly sensitive to DNA damage aged mice. This concept led us investigate the variation also major with age. Lymphocyte from 60 healthy donors, 20 90 years, 41 untreated chronic lymphocytic leukemia patients were studied. was analyzed real-time...
The first-step in diagnosis of myelodysplastic neoplasms (MDS) is essentially based on bone marrow cytomorphology. However, cytomorphology MDS often a difficult exercise, subject to inter-operator variability. Our study aims evaluate whether the combination two dysplasia scores, extended Ogata score and MDS-CBC score, could improve screening patients among with chronic cytopenia.
Background: Aging is a risk factor for developing malignant hemopathies including chronic lymphocytic leukemia (CLL). We evaluated the relevance of BACH2 and PRDM1 gene expression in aging immune cells immunodeficiency associated with CLL.Methods: Peripheral blood mononuclear were isolated from untreated CLL patients (n=41) age-matched healthy donors (HD; n=60). T B purified (95%-99%) by magnetic isolation. BACH2, PRDM1, PD1, PDL1 CDKN2A (p16INK4A) transcripts quantified using RT-qPCR....
Background: Areliable frailty score remains needed to better define the unsuspected vulnerable population that does not benefit from chemotherapy. In literature, three clinical (functional decline, cognitive impairment (CI) and comorbidities) two biological (low albumin level high IL-6 level) factors are associated with poor overall survival. Aims: To develop evaluate a simple clinico-biological tool for screening of vulnerability prediction survival in patients (pts) malignant hemopathies....
Background: Age-associated immunodeficiencies increase the probability of developing malignant hemopathies including chronic lymphocytic leukemia (CLL). One reason could be due to accumulation genetic/epigenetic changes leading deregulation transcriptional programs in lymphocytes. The transcription factor FOXP1 is a key regulator B cell development and abnormally expressed malignancies. We investigated significance inhibitory immune checkpoint (PD-1, PD-L1 TIM-3) expression major lymphocyte...
Background: We previously investigated BACH2/RPDM1 gene expression in B/T cells from chronic lymphocytic leukemia (CLL) patients and aged‐matched healthy donors (HD) to understand the immunosenescence with aging, which showed that BACH2/PRDM1 are strongly correlated aging. Recent data show candidate immune suppressor FOXP1 is an important regulator of CLL pathogenesis Aims: further significance BACH2, PRDM1 , inhibitory molecule T/B patients. Methods: Peripheral blood mononuclear were...
Abstract Background: Aging is a risk factor for developing malignant hemopathies including chronic lymphocytic leukemia (CLL). We evaluated the relevance of BACH2 and PRDM1 gene expression in aging immune cells immunodeficiency associated with CLL. Methods: Peripheral blood mononuclear were isolated from untreated CLL patients (n=41) age-matched healthy donors (HD; n=60). T B purified (95%-99%) by magnetic isolation. BACH2, PRDM1, PD1, PDL1 CDKN2A (p16INK4A) transcripts quantified using...