A5079623767- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Sirtuins and Resveratrol in Medicine
- Liver Disease Diagnosis and Treatment
- Regulation of Appetite and Obesity
- Diet, Metabolism, and Disease
- Mitochondrial Function and Pathology
- PARP inhibition in cancer therapy
- Biochemical Analysis and Sensing Techniques
- Metabolism, Diabetes, and Cancer
- Autophagy in Disease and Therapy
Novo Nordisk Foundation
2019-2021
University of Copenhagen
2019-2021
Glucagon is well known to regulate blood glucose but may be equally important for amino acid metabolism. Plasma levels of acids are regulated by glucagon-dependent mechanism(s), while stimulate glucagon secretion from alpha cells, completing the recently described liver-alpha cell axis. The mechanisms underlying cycle and possible impact hepatic steatosis unclear. We assessed clearance in vivo mice treated with a receptor antagonist (GRA), transgenic 95% reduction steatosis. In addition, we...
SBI-0206965, originally identified as an inhibitor of the autophagy initiator kinase ULK1, has recently been reported a more potent and selective AMP-activated protein (AMPK) relative to widely used, but promiscuous Compound C/Dorsomorphin. Here, we studied effects SBI-0206965 on AMPK signalling metabolic readouts in multiple cell types, including hepatocytes, skeletal muscle cells adipocytes. We observed dose dependently attenuated activator (991)-stimulated ACC phosphorylation inhibition...
Neurons in the arcuate nucleus of hypothalamus are involved regulation food intake and energy expenditure, dysregulation signalling these neurons promotes development obesity. The role rate-limiting enzyme NAD+ salvage pathway, nicotinamide phosphoribosyltransferase (NAMPT), for homeostasis by has not been extensively studied.We determined whether Nampt mRNA or protein levels mice were affected diet-induced obesity, fasting re-feeding, leptin ghrelin treatment. Primary hypothalamic treated...
Nicotinamide phosphoribosyltransferase (NAMPT) converts nicotinamide to NAD+. As low hepatic NAD+ levels have been linked the development of nonalcoholic fatty liver disease, we hypothesized that ablation Nampt would affect susceptibility injury in response diet-induced metabolic stress. Following 3 weeks on a low-methionine and choline-free 60% high-fat diet, hepatocyte-specific knockout (HNKO) mice accumulated less triglyceride than WT littermates but had increased histological scores for...
Agouti-related protein (AgRP) neurons in the arcuate nucleus of hypothalamus regulates food intake and whole-body metabolism. NAD+ multiple cellular processes controlling energy Yet, its role hypothalamic AgRP to control is poorly understood. Here, we aimed assess whether genetic deletion nicotinamide phosphoribosyltransferase (Nampt), a rate-limiting enzyme production, affects neuronal function impact metabolism intake. Metabolic parameters during fed fasted states, upon systemic ghrelin...