A5065583372- Pancreatic function and diabetes
- Birth, Development, and Health
- Diabetes and associated disorders
- RNA Research and Splicing
- Single-cell and spatial transcriptomics
- Obesity, Physical Activity, Diet
- Epigenetics and DNA Methylation
- Gestational Diabetes Research and Management
- Hymenoptera taxonomy and phylogeny
- DNA Repair Mechanisms
- Smoking Behavior and Cessation
- Genetic Neurodegenerative Diseases
- Genomics and Chromatin Dynamics
- Health, Environment, Cognitive Aging
- Eicosanoids and Hypertension Pharmacology
- Biochemical Acid Research Studies
- Neonatal Respiratory Health Research
- Cardiovascular Health and Risk Factors
- Plant and animal studies
- Lepidoptera: Biology and Taxonomy
- RNA regulation and disease
- Mitochondrial Function and Pathology
- Nutritional Studies and Diet
University of California, San Diego
2020-2025
Howard Hughes Medical Institute
2020-2024
Baylor College of Medicine
2014-2015
Studies reveal that electronic cigarette (e-cigarette) and hookah use are increasing among adolescents young adults. However, the long-term health effects unknown, especially with regards to pregnancy. Because of increased in women reproductive age, unknown risks, our primary objectives were determine perceived risks e-cigarette pregnancy, learn common colloquial terms associated e-cigarettes. Furthermore, we sought if there is a stigma pregnancy.Eleven focus groups including 87 participants...
Transcription factors play vital roles in neuron development; however, little is known about the role of these proteins maintaining neuronal homeostasis. Here, we show that transcription factor RREB1 (Ras-responsive element-binding protein 1) essential for survival mammalian brain. A spontaneous mouse mutation causing loss a nervous system–enriched Rreb1 transcript associated with progressive cerebellar Purkinje cells and ataxia. Analysis chromatin immunoprecipitation sequencing, along RNA...
Abstract Cell type-specific regulatory programs that drive type 1 diabetes (T1D) in the pancreas are poorly understood. Here we performed single nucleus multiomics and spatial transcriptomics up to 32 non-diabetic (ND), autoantibody-positive (AAB+), T1D donors. Genomic profiles from 853,005 cells mapped 12 pancreatic cell types, including multiple exocrine sub-types. Beta, acinar, other related cellular niches, had altered abundance gene activity progression, distinct pathways AAB+ compared...
Background Fetal exposure to nicotine is not limited maternal tobacco smoke, as electronic cigarettes have an increased prevalence of use among reproductive aged women. Animal models shown that in utero associated with risk asthma and cognitive deficits, well expression the hippocampal glucocorticoid receptor. We hypothesized epigenetic changes offspring lung brain which may contribute a memory this Methods Sprague‐Dawley rat dams received either saline or 2 mg/kg by intraperitoneal...
Abstract Physiological variability in pancreatic cell type gene regulation and the impact on diabetes risk is poorly understood. In this study we mapped types using single multiomic (joint RNA-seq ATAC-seq) profiling 28 non-diabetic donors combination with data from 35 Human Pancreas Analysis Program. We identified widespread associations age, sex, BMI, HbA1c, where regulatory responses were highly type- phenotype-specific. beta cells, donor age associated hypoxia, apoptosis, unfolded...
The Microgastrinae (Hymenoptera: Braconidae) from ten islands of the Canadian Arctic Archipelago (CAA) and Greenland were studied based on 2,183 specimens deposited in collections. We report a total 33 species six genera, more than doubling totals previously known. Most (75.7%) have distribution restricted to Nearctic, with nine those (27.3%) confirmed be High endemics another 10 considered very likely as well – accounting for all those, half found are endemic region. most diverse genera...