A5032370147- Nanoparticle-Based Drug Delivery
- Light effects on plants
- Photoreceptor and optogenetics research
- Advanced biosensing and bioanalysis techniques
- Photodynamic Therapy Research Studies
- Muscle metabolism and nutrition
- Genetics and Physical Performance
- Circadian rhythm and melatonin
- Chemotherapy-induced organ toxicity mitigation
- bioluminescence and chemiluminescence research
- Photosynthetic Processes and Mechanisms
- Cancer Treatment and Pharmacology
- Epigenetics and DNA Methylation
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- DNA and Nucleic Acid Chemistry
Inserm
2023-2024
Institut Curie
2023-2024
Université Paris Sciences et Lettres
2023-2024
Institute of Biological Chemistry, Academia Sinica
2018-2023
Centre National de la Recherche Scientifique
2023
Université Paris-Saclay
2023
Chung Yuan Christian University
2016-2019
Photolyases, a ubiquitous class of flavoproteins, use blue light to repair DNA photolesions. In this work, we determined the structural mechanism photolyase-catalyzed cyclobutane pyrimidine dimer (CPD) lesion using time-resolved serial femtosecond crystallography (TR-SFX). We obtained 18 snapshots that show time-dependent changes in four reaction loci. used these results create movie depicts CPD lesions picosecond-to-nanosecond range, followed by recovery enzymatic moieties involved...
Photolyases and cryptochromes form an almost ubiquitous family of blue light photoreceptors involved in the repair maintenance DNA integrity or regulatory control. We found that one cryptochrome from green alga Chlamydomonas reinhardtii (CraCRY) is capable both, control transcript levels sexual cycle a positive (germination) negative manner (mating ability), as well catalyzing UV-DNA lesions. Its 1.6 Å crystal structure shows besides FAD chromophore aromatic tetrad indispensable animal-like...
Encapsulating cisplatin (CDDP) into liposomes to form lipid-platinum-chloride nanoparticles (LPC NPs) has shown a promising anticancer effect in melanoma, bladder, and liver cancer models. This of LPC NPs challenges us study its implications combination with photodynamic therapy (PDT). Herein, we report the therapeutic efficacy PDT+LPC on xenograft model oral squamous cell carcinoma (OSCC). Results showed that significantly reduced tumor volume by up ~112%. Meanwhile, LPC, PDT+CDDP, or CDDP...
Abstract Apurinic/apyrimidinic (AP) sites, 5-formyluracil (fU) and 5-formylcytosine (fC) are abundant DNA modifications that share aldehyde-type reactivity. Here, we demonstrate polyamines featuring at least one secondary 1,2-diamine fragment in combination with aromatic units form covalent adducts upon reaction AP sites (with concomitant cleavage of the strand), fU and, to a lesser extent, fC residues. Using small-molecule mimics site fU, show 1,2-diamines leads formation unprecedented...
The knowledge of manipulating size biomaterials encapsulated drug into nano-scale particles has been researched and developed in treating cancer. Cancer is the second worldwide cause death, therefore it critical to treat cancers challenging with therapeutic modality various mechanisms. Our preliminary investigation studied cisplatin lipid-based nanoparticle examined effect on xenografted animal model. We used mice tumor volume ranging from 195 214 mm<sup>3</sup> then few were grouped three...
Although physical activity is important for the athlete’s health and performance, it may also lead to Deoxyribonucleic Acid (DNA) damage, which have long-term consequences affect performance. This article summarizes different types of DNA damage that occur in athletes, including their potential risk causes, such as mechanical stress, heat oxidative stress. Furthermore, several mechanisms by might performance are discussed. Various strategies diet nutrition, antioxidant supplements, cooling...