A5034575987- MicroRNA in disease regulation
- Viral gastroenteritis research and epidemiology
- Phytochemicals and Antioxidant Activities
- Computational Drug Discovery Methods
- Gut microbiota and health
- Virus-based gene therapy research
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Diet and metabolism studies
- Genomics, phytochemicals, and oxidative stress
- Animal Virus Infections Studies
- Telemedicine and Telehealth Implementation
- Biological Activity of Diterpenoids and Biflavonoids
- Gestational Diabetes Research and Management
- Bioinformatics and Genomic Networks
- Mobile Health and mHealth Applications
- Neurological diseases and metabolism
- Bioactive Compounds and Antitumor Agents
- Cholinesterase and Neurodegenerative Diseases
- Ethics in Clinical Research
- Rheumatoid Arthritis Research and Therapies
- Autophagy in Disease and Therapy
- Alzheimer's disease research and treatments
- Nutrition and Health in Aging
- Genetics, Aging, and Longevity in Model Organisms
Universidad Nacional Autónoma de México
2020-2024
Instituto Nacional de Pediatria
2019-2020
Instituto Politécnico Nacional
2015-2019
Center for Research and Advanced Studies of the National Polytechnic Institute
2015-2019
Cellular senescence is a cellular condition that involves significant changes in gene expression and the arrest of cell proliferation. Recently, it has been suggested experimental models elimination senescent cells with pharmacological methods delays, prevents, improves multiple adverse outcomes related to age. In this sense, so-called senoylitic compounds are class drugs selectively eliminates (SCs) could be used order delay such outcomes. Interestingly, first senolytic drug (navitoclax)...
Preclinical studies suggest that senolytic compounds such as quercetin (a natural product) and dasatinib synthetic decrease senescent cells, reduce inflammation, alleviate human frailty. This evidence has opened a new field of research for studying the effect these on age-related dysfunction diseases.The present study performed in silico we identified potential candidates from an extensive database contains products (NPs) semi-synthetic (SMSs).Computer programs Chemminer rcdk packages, which...
Parkinson's disease (PD) is the second most common neurodegenerative in older individuals worldwide. Pharmacological treatment for such a consists of drugs as monoamine oxidase B (MAO-B) inhibitors to increase dopamine concentration brain. However, have adverse reactions that limit their use extended periods; thus, design less toxic and more efficient compounds may be explored. In this context, cheminformatics computational chemistry recently contributed developing new search therapeutic...
Many natural products have been acquired from plants for their helpful properties. Medicinal are used treating a variety of pathologies or symptoms. The axes many pathological processes inflammation, oxidative stress, and senescence. This work is focused on identifying Mexican medicinal with potential anti-oxidant, anti-inflammatory, anti-aging, anti-senescence effects through network analysis chemoinformatic screening phytochemicals. We computational methods to analyze drug-like...
Peripheral venous hypertension has emerged as a prominent characteristic of disease (VD). This causes lower limb edema due to impaired blood transport in the veins. The phlebotonic drugs use showed moderate evidence for reducing slightly legs and little or no difference quality life. To enhance probability favorable experimental results, virtual screening procedure was employed identify molecules with potential therapeutic activity VD. Compounds obtained from multiple databases, namely AC...
Chronic venous disease (CVD) is a prevalent condition in adults, significantly affecting the global elderly population, with higher incidence women than men. The modulation of gene expression through microRNA (miRNA) partly regulated development cardiovascular (CVD). Previous research identified functional analysis seven genes (CDS2, HDAC5, PPP6R2, PRRC2B, TBC1D22A, WNK1, and PABPC3) as targets miRNAs related to CVD. In this context, emerge essential candidates for CVD diagnosis,...
It is known that levels of the anti-apoptotic protein survivin are reduced during Murine norovirus MNV-1 and Feline calicivirus (FCV) infection as part apoptosis establishment required for virus release propagation in host. Recently, our group has reported overexpression causes a reduction FCV synthesis viral progeny production, suggesting may affect early steps replicative cycle. Using immunofluorescence assays, we observed survivin, resulted not only transfected but also neighboring...
Chiranthodendron pentadactylon Larreat is a tree native to southeastern Mexico and Guatemala. Its flower used in Mexican folk medicine treat variety of diseases, including conditions blood pressure. However, scientific information on its usefulness this pathology lacking. The present study evaluates the effect methanolic extract (ME) from active constituents heart rate (HR) mean arterial pressure (MAP) anesthetized rats (MAPHR). also analyzed effects rat-isolated aortic rings (RIAR) rat...