A5064943213- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Insect symbiosis and bacterial influences
- Viral gastroenteritis research and epidemiology
- HIV Research and Treatment
- Bacteriophages and microbial interactions
- Heat shock proteins research
- Vibrio bacteria research studies
- COVID-19 Clinical Research Studies
- Vector-Borne Animal Diseases
- Long-Term Effects of COVID-19
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Antibiotic Resistance in Bacteria
- interferon and immune responses
- Microbial infections and disease research
- Cystic Fibrosis Research Advances
- Studies on Chitinases and Chitosanases
- Epigenetics and DNA Methylation
- Bacterial biofilms and quorum sensing
- Ubiquitin and proteasome pathways
- COVID-19 Impact on Reproduction
- Genomics and Chromatin Dynamics
- PARP inhibition in cancer therapy
- COVID-19 and healthcare impacts
Universidad Autónoma de la Ciudad de México
2015-2024
Instituto Politécnico Nacional
2003-2019
Mexican Social Security Institute
2019
Institute for Social Security and Services for State Workers
2019
Instituto Nacional de Enfermedades Respiratorias
2019
Center for Research and Advanced Studies of the National Polytechnic Institute
2003
Abstract To date, mother‐to‐fetus transmission of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), responsible for the disease 2019 (COVID‐19) pandemic, remains controversial. Although placental COVID‐19 infection has been documented in some cases during second‐ and third‐trimesters, no reports are available first trimester pregnancy, SARS‐CoV‐2 protein found fetal tissues. We studied placenta organs from an early pregnancy miscarriage a maternal by immunohistochemical, reverse...
ABSTRACT Cellular proteins play many important roles during the life cycle of all viruses. Specifically, host cell nucleic acid-binding interact with viral components positive-stranded RNA viruses and regulate translation, as well replication. Here, we report that nucleolin, a ubiquitous multifunctional nucleolar shuttling phosphoprotein, interacts Norwalk virus feline calicivirus (FCV) genomic 3′ untranslated regions (UTRs). Nucleolin can also form complex in vitro recombinant NS6 -7...
Since many antiviral drugs are designed to interfere with viral genome replication, understanding this step in the replicative cycle has gained importance recent years. Replication for RNA viruses occurs cellular compartments mainly originated from production and reorganization of virus-induced membranes. Dengue virus translates, replicates assembles new particles within membranes endoplasmic reticulum. In these compartments, all components required replication recruited, making process...
The synthesis of plus and minus RNA strands several viruses requires as a first step the interaction some viral regulatory sequences with cellular proteins. dengue 4 virus genome, single-stranded, positive-polarity RNA, is flanked by two untranslated regions (UTR) located in 5' 3' ends. 3'UTR minus-strand [3'UTR (-)] has been thought to function promoter for plus-strand RNA. To study initial between this proteins, mobility shift assays were performed, four ribonucleoprotein complexes (I...
We characterized natural vertical transmission of Zika virus in pools Aedes aegypti larvae hatched from eggs collected Jojutla, Morelos, Mexico. Of the 151 analyzed, 17 tested positive for RNA; infectious was successfully isolated 1 (31N) C6/36 cells. Real-time quantitative PCR and indirect immunofluorescence assays confirmed identity isolate, named isolate 31N; plaque Vero cells demonstrated isolate's infectivity a mammalian cell line. obtained complete genome 31N by next-generation...
Dengue virus (DENV) is an important flavivirus that transmitted to humans by Aedes mosquitoes, where it can establish a persistent infection underlying vertical and horizontal transmission. However, the exact mechanism of DENV not well understood. Recently miR-927 was found be upregulated in C6/36-HT cells at 57 weeks (C6-L57), suggesting its participation during this type infection. The aim study determine role with 2. results indicate overexpression C6-L57 acutely infected according time...
During pregnancy, the Zika virus (ZIKV) replicates in placenta and central nervous system (CNS) of infected fetuses; nevertheless, ability ZIKV to replicate other fetal tissues has not been extensively characterized.We researched whether dissemination congenitally-acquired outside CNS exists by searching for accumulation viral envelope protein, ribonucleic acid (RNA), infectious particles different organs a deceased newborn with Congenital Syndrome. A real-time qualitative polymerase chain...
Chromatin in cervical cancer (CC) undergoes chemical and structural changes that alter the expression pattern of genes.Recently, a potential mechanism, which regulates gene at transcriptional levels is proteolytic clipping histone H3.However, until now this process CC has not been reported.Using HeLa cells as model human samples from patients with CC, we identify H3 cleavage was lower compared control tissue.Additionally, performed by serine aspartyl proteases cells.These results suggest...
This is a case report of young adult who died COVID-19 twelve days after admission, with coronavirus nucleocapsid protein and lipofuscin found in the heart kidney tissues, providing further evidence role SARS-CoV-2 cellular senescence.
ABSTRACT Zika virus (ZIKV) is an emerging arthropod-borne flavivirus associated with severe congenital malformations and neurological complications. Although the ZIKV genome well characterized, there limited information regarding changes after cell isolation culture adaptation. We isolated, passaged in Vero cells, from serum of a symptomatic male patient compared viral genomes before culture. Single nucleotide polymorphisms were characteristic among serum-circulating genomes, while such...