A5011445115- Parasites and Host Interactions
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Helminth infection and control
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Radiopharmaceutical Chemistry and Applications
- Immune Cell Function and Interaction
- Parasite Biology and Host Interactions
- Glycosylation and Glycoproteins Research
- Parasitic Infections and Diagnostics
- Parasitic infections in humans and animals
- Social and Educational Sciences
- Immune cells in cancer
- Gut microbiota and health
BioInvent (Sweden)
2020-2022
Lund University
2014-2017
T-helper 2 (Th2) cell responses defend against parasites. Although dendritic cells (DCs) are vital for the induction of T-cell responses, DC subpopulations that induce Th2 in intestine unidentified. Here we show intestinal Trichuris muris worms and Schistosoma mansoni eggs do not develop mice with IRF-4-deficient DCs (IRF-4f/f CD11c-cre). Adoptive transfer conventional DCs, particular CD11b-expressing from intestine, is sufficient to prime S. mansoni-specific responses. Surprisingly,...
Low- and high-dose infections with the murine large intestinal nematode Trichuris muris are associated induction of adaptive Th1 Th2 responses, respectively, in mesenteric lymph nodes (MLN). Classical dendritic cells (cDC) accumulate mucosa MLN upon T. infection, yet their role driving responses to infection remains largely unknown. We performed low- mice deficient defined cDC subsets investigate immune responses. Mice lacking IRF4-dependent failed clear a displayed impaired Conversely,...
Abstract The pleiotropic TNF-α:TNFR axis plays a central role in the immune system. While cellular expression of TNFR1 is broad, TNFR2 mainly restricted to cells and especially high on T regs. therapeutic potential targeting for cancer treatment has been previously indicated but mechanism-of-action (MoA) these reagents remains unclear, with conflicting data reported by different investigators. To gain further insight, we identified characterized wide panel human mouse TNFR2-specific...
<h3>Background</h3> The pleiotropic TNF-alpha:TNFR axis plays a central role in the immune system. While cellular expression of TNFR1 is broad, TNFR2 mainly restricted to cells. therapeutic potential targeting for cancer treatment has been previously indicated and gain further insight, we characterized wide panel antibodies, generated from n-CoDeR F.I.R.S.T™ target antibody discovery platform. We identified parallel human mouse specific, complete ligand (TNF-alpha) blocking antibodies could...
Abstract The pleiotropic TNF-α:TNFR axis plays a central role in immune regulation. While the cellular expression of TNFR1 is broad, TNFR2 mainly restricted to cells. therapeutic potential targeting for cancer treatment has been previously indicated and gain further insight, we generated wide panel TNFR2-specific antibodies using n-CoDeR F.I.R.S.T™ target antibody discovery platforms. We identified against mouse or human that could block TNF-α binding showed potent anti-tumor activity...