A5092189419- Peptidase Inhibition and Analysis
- Diabetes Treatment and Management
- Pneumocystis jirovecii pneumonia detection and treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Blood disorders and treatments
- Immunotherapy and Immune Responses
- Adenosine and Purinergic Signaling
- Estrogen and related hormone effects
- Cystic Fibrosis Research Advances
- Immune cells in cancer
- Neuropeptides and Animal Physiology
- Neonatal Respiratory Health Research
- Inflammatory mediators and NSAID effects
- Immune Cell Function and Interaction
University of East Sarajevo
2023-2024
Background/Aim. Piclidenoson (CF101, IB-MECA), a selective agonist of the A3 adenosine receptor (A3AR), is used in clinical trials for treatment psoriasis. Emerging data from vitro and vivo studies suggest that piclidenoson possesses anti-inflammatory immunomodulatory properties, but its action on human peripheral blood mononuclear cells (PBMCs) remains unknown. The aim this study was to examine effects model phytohaemagglutinin (PHA)-stimulated PBMCs culture. Methods. Human were isolated...
Dysfunction of neutrophils in patients with cystic fibrosis (CF) is best characterized bronchoalveolar lavage (BAL), whereas peripheral blood are less examined, and the results contradictory, especially younger populations. Therefore, this work aimed to study functional phenotypic changes circulating children CF. The included 19 CF (5-17 years) 14 corresponding age-matched healthy children. Isolated were cultured either alone or different stimuli. Several functions studied: apoptosis,...
Sitagliptin, an anti-diabetic drug, is a dipeptidyl peptidase (DPP)-4/CD26 inhibitor with additional anti-inflammatory and immunomodulatory properties. In this study, we investigated for the first time effect of sitagliptin on differentiation functions human dendritic cells generated from monocytes (MoDCs) 4 days using standard GM-CSF/IL-4 procedure. LPS/IFN-γ treatment 24 h was used maturation induction MoDCs. Sitagliptin added at highest non-cytotoxic concentration (500 µg/mL) either...
<p><strong>Introduction. </strong>GLP-1R agonists (GLP-1RAs) are a type of anti-hyperglycemic medications used for the management 2 diabetes mellitus (T2DM). In addition to glucose-lowering effects, GLP-1R also provide further advantages by promoting weight loss and controlling blood pressure. Furthermore, GLP-1RAs have been reported their therapeutic benefits in neurological, cardiovascular, endocrine, metabolic diseases. Emerging evidence from many...
Dapsone is a sulfone used in treating inflammatory skin conditions. Despite its widespread dermatological use, the pharmacological actions of dapsone remain poorly understood. Here, we examined how different aspects neutrophil functions are affected by dapsone. Peripheral blood neutrophils from healthy donors were stimulated with phorbol-12-myristate-13-acetate (PMA), N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP), or calcium ionophore (CaI) primed cytokines prior to stimulation,...