A5073240267- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Lung Cancer Treatments and Mutations
- Delphi Technique in Research
- Cardiac, Anesthesia and Surgical Outcomes
- High Altitude and Hypoxia
- Spaceflight effects on biology
- Cardiovascular and exercise physiology
- Airway Management and Intubation Techniques
- Asthma and respiratory diseases
- Tracheal and airway disorders
- Heart Rate Variability and Autonomic Control
- Pulmonary Hypertension Research and Treatments
- Pharmacological Effects and Assays
- Long-Term Effects of COVID-19
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Education, Psychology, and Social Research
- Cardiovascular and Diving-Related Complications
- 3D Printing in Biomedical Research
- Lung Cancer Research Studies
- Pediatric health and respiratory diseases
- Cardiac electrophysiology and arrhythmias
- Hemodynamic Monitoring and Therapy
Masaryk University
2016-2025
University Hospital Brno
2016-2025
St. Anne's University Hospital Brno
2021-2024
International Clinical Research Center, St. Anne's University Hospital Brno
2023
University Hospital Plzen
2020-2021
Central European Institute of Technology – Masaryk University
2020
Ocní klinika
2018
The role of electrocardiography (ECG) in predicting mortality patients with chronic obstructive pulmonary disease (COPD) has not been sufficiently established. Research question: Is a normal ECG associated better prognosis than an abnormal COPD? parameters were assessed enrolled the Czech Multicenter Database COPD. We ECGs from baseline (August 2013) until December 31, 2019, or death. primary endpoint was 5-year overall survival depending on findings. A total 300 subjects study and 143 died...
This randomized controlled trial evaluated the effectiveness of two home-based, stand-alone inspiratory muscle training (IMT) modalities - flow-resistive loading with biofeedback (IRFL) and mechanical threshold (MTL) compared to a sham MTL group for improving performance functional exercise capacity in COPD patients. Thirty-six patients trained at home 8 weeks under remote monitoring. Primary outcomes included assessed via Test Incremental Respiratory Endurance (TIRE), capacity, lung...
Measurement of ventilatory efficiency, defined as minute ventilation per unit carbon dioxide production (VE/VCO2), by cardiopulmonary exercise testing (CPET) has been proposed a screen for hyperventilation syndrome (HVS). However, increased VE/VCO2 may be associated with other disorders which need to distinguished from HVS. A more specific marker HVS CPET would clinically useful. We hypothesized control during is abnormal in patients HVS.Patients who underwent years 2015 through 2017 were...
This position paper has been drafted by experts from the Czech national board of diseases with bronchial obstruction, Pneumological and Phthisiological Society. The statements recommendations are based on both results randomized controlled trials data cross-sectional prospective real-life studies to ensure they as close possible context daily clinical practice current health care system Republic. Chronic Obstructive Pulmonary Disease (COPD) is a preventable treatable heterogeneous syndrome...
This study investigated an alternative home-based cardiac telerehabilitation model in consideration of the recommendations for COVID-19 quarantine people diagnosed with coronary heart disease (CHD). We hypothesized that using a 200 m fast walking test (200 mFWT) and would create effective rehabilitation (CR) intervention could improve cardiorespiratory fitness. Participants (n = 19, mean age 60.4 ± 9.6) 8-week performed regular physical exercise at target rate zone determined by calculations...
Background: Respiratory parameters are important predictors of prognosis in the COPD population. Global Initiative for Obstructive Lung Disease (GOLD) 2017 Update resulted a vertical shift patients across categories, with category B being most populous and clinically heterogeneous. The aim our study was to investigate whether respiratory might be associated increased all-cause mortality within GOLD patients. Methods: data were extracted from Czech Multicentre Research Database, prospective,...
Introduction Ventilatory efficiency (V E /VCO 2 slope) has been shown superior to peak oxygen consumption (VO ) for prediction of post-operative pulmonary complications in patients undergoing thoracotomy. V slope is determined by ventilatory drive and ventilation/perfusion mismatch whereas VO related cardiac output arteriovenous difference. We hypothesized pre-operative predicts cardiovascular lung resection. Methods Lung resection candidates from a published study were evaluated post-hoc...
Abstract Background Physical activity is a crucial demand on cystic fibrosis treatment management. The highest value of oxygen uptake (VO 2peak ) an appropriate tool to evaluate the physical in these patients. However, there are several other valuable CPET parameters describing exercise tolerance (W peak , VO 2VT1 2VT2, 2 /HR etc.), and helping better understand effect specific (V E V T D /V etc.). Limited data showed ambiguous results this improvement after CFTR modulator treatment....
Background: Patient adherence to an inhaled medication application technique (A-ApplT) represents a major health-care issue in patients with chronic obstructive pulmonary disease (COPD). However, there is lack of studies evaluating this thoroughly. The aim our study was introduce universal easy-to-use method assessing the A-ApplT moderate very severe COPD individuals. Methods: Czech Multicenter Research Database (COPD CMRD), large observational prospective study, used as source clinical...
BackgroundCardiopulmonary exercise testing parameters including ventilatory efficiency (VE/VCO2 slope) are used for risk assessment of lung resection candidates. However, many patients unable or unwilling to undergo exercise. VE/VCO2 slope is closely related the partial pressure end-tidal carbon dioxide (PETCO2). We hypothesized PETCO2 at rest predicts postoperative pulmonary complications.MethodsConsecutive candidates were included in this prospective multicenter study. Postoperative...
Pneumothorax (PTX) is one of the most common complications transbronchial biopsy (TBB). Previous research suggests that upper pulmonary lobe TBB may be associated with increased risk PTX development. The aim this study was to compare after performed from different lobes.All bronchoscopic records period January 1st, 2015 - December 31st, 2017 (from Department Respiratory Diseases, University Hospital Brno, Czech Republic) were retrospectively analyzed. Of 3542 records, 796 patients underwent...
Cardiac side effects of some pulmonary drugs are observed in clinical practice. Aminophylline, a methylxanthine bronchodilator with documented proarrhythmic action, may serve as an example. Data on the action aminophylline cardiac cell electrophysiology and contractility not available. Hence, this study was focused analysis changes beat rate contraction force human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) HL-1 presence increasing concentrations (10 µM-10 mM hPSC-CM 8-512 µM...
Introduction: Recently, the Global Initiative for Chronic Obstructive Lung Disease (GOLD) has published an update on Strategy Prevention, Diagnosis and Management of COPD, introducing a new classification chronic obstructive pulmonary disease (COPD). Our aim was to assess prognostic value GOLD system in comparison with previous systems (GOLD stages I–IV groups A-D) BODE index. Methods: We used data 784 patients COPD from Czech Multicenter Research Database COPD. Patient survival analyzed use...
Aim: To compare survival outcomes in patients with non-small cell lung cancer (NSCLC) treated modern-era drugs (antifolates, antiangiogenics, tyrosine kinase and anaplastic lymphoma inhibitors, immunotherapy) treatment initiation 2011-12 2015-16, respectively. Patients Methods: Prospective data from Czech TULUNG Registry (960 512 2015-16) were analyzed. Kaplan-Meier analysis was used to estimate overall (OS) progression-free (PFS); Cox proportional hazards model assess factors associated...
Background: Adherence to inhaled medication constitutes a major problem in patients with chronic obstructive pulmonary disease (COPD) globally. However, large studies evaluating adherence its entirety and capturing variety of potentially associated factors are still lacking. Objective: To study both elementary types COPD "real-life" assess relationships wide-ranging spectrum clinical parameters. Methods: Data from the Czech Multicentre Research Database (CMRD) COPD, an observational...
Abstract Research objective was to detail COVID-19’s natural trajectory in relation the Czech population’s viral load. Our prospective detailed daily questionnaire-based telemonitoring study evaluated impact among 105 outpatients. In accordance with government quarantine requirements, outpatients were divided into a cohort two negative tests at end of disease (40 patients) and new algorithm (65 following 14-day quarantine. Median follow-up differed significantly between 2 groups (23 days vs....
Data regarding real-life effectiveness of any treatment may improve clinical decision-making. The aim this study was to evaluate tyrosin-kinase inhibitors, bevacizumab and pemetrexed as first-line treatments in patients with advanced/metastatic non-small cell lung cancer (NSCLC).