A5064516306- Knee injuries and reconstruction techniques
- Osteoarthritis Treatment and Mechanisms
- Tendon Structure and Treatment
- Animal Nutrition and Physiology
- Aquaculture disease management and microbiota
- Aquaculture Nutrition and Growth
- Periodontal Regeneration and Treatments
- Bone fractures and treatments
- Rabbits: Nutrition, Reproduction, Health
- Bone Tissue Engineering Materials
- Physiological and biochemical adaptations
- Mesenchymal stem cell research
- Sports injuries and prevention
- Orthopaedic implants and arthroplasty
- Fish Ecology and Management Studies
- Dental Implant Techniques and Outcomes
- Orthopedic Surgery and Rehabilitation
- Tissue Engineering and Regenerative Medicine
- Gastrointestinal motility and disorders
- Forensic Entomology and Diptera Studies
- Lower Extremity Biomechanics and Pathologies
- Total Knee Arthroplasty Outcomes
- Shoulder Injury and Treatment
- Diet and metabolism studies
- Muscle Physiology and Disorders
University of Milan
2015-2024
Università degli Studi del Piemonte Orientale “Amedeo Avogadro”
2016
Istituto Ortopedico Galeazzi
2013-2015
Istituti di Ricovero e Cura a Carattere Scientifico
2014-2015
John Wiley & Sons (United States)
2015
Bioengineering Center
2015
National Center for Genetic Engineering and Biotechnology
2015
Cornell University
2012
Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Legnaro
2002
Dietary supplementations with L-glutamine and/or nucleotides were screened for their effects on intestinal mucosa in 16 female weaning piglets. The animals transported to the university's facilities 24 hours after weaning. They grouped four a pen controlled environmental conditions and fed one of following diets 28 days: control diet (C); C+0.5% (G); C+0.05% "nucleotides" (N); C+0.5 % L-glutamine+0.05% (GN). Individual body weights feed intake per group recorded at beginning end study as...
The enteric nervous system (ENS) contains chemically coded populations of neurons that serve specific functions for the control gastrointestinal tract. ability to modify their chemical code in response luminal changes has recently been discovered. It is possible neuronal plasticity may sustain adaptability gut intestinal activity or injury, and respond an altered environment by changing neuropeptide expression.We used immunohistochemical methods investigate presence localization several glia...
This study (i) developed a scaffold made of collagen I designed for hosting the autologous chondrocytes, (ii) focused on optimization chondrocytes seeding by addition fibrin glue, and (iii) investigated culture time ideal maturation in vitro. In first part study, fresh were isolated from infant swine articular cartilage, immediately seeded onto sponges either medium or fibrinogen order to show contribute glue cell survival into scaffold. second expanded vitro then resuspended fibrinogen,...
One of the crucial points for a successful tissue-engineering approach cartilage repair is represented by level in vitro maturation engineered tissue before implantation. The purpose this work was to evaluate effect cartilaginous samples on quality after vivo Samples were obtained from isolated swine articular chondrocytes embedded fibrin glue. cell-fibrin composites either cultured or directly implanted 1, 5, and 9 weeks. Other experimental precultured 1 5 weeks then 4 additional All...
Tendinopathy is a big burden in clinics and it represents 45% of musculoskeletal lesions. Despite the relevant social impact, both pathogenesis development tendinopathy are still under-investigated, thus limiting therapeutic advancement this field. The purpose study was to evaluate dose-dependent time-related tissue-level changes occurring collagenase-induced rat Achilles tendons, order establish standardized model for future pre-clinical studies. With purpose, 40 Sprague Dawley rats were...
Substantial epidemiological evidence indicates that a diet rich in polyphenols protects against developing type 2 diabetes. The phenylethanoid glycoside verbascoside/acteoside, widespread polyphenolic plant compound, has several biological properties including strong antioxidant, anti-inflammatory and neuroprotective activities. aim of this research was to test the possible effects verbascoside on pancreatic β-cells, target never tested before. Mouse human β-cells were incubated with (0.8–16...
Probiotic research has been approached, above all in recent years, by widely differing points of view, both for human and animal uses. Lactic acid bacteria release bacteriocins, some them may function as probiotic. The aim the present study was to investigate effects dietary supplementation with probiotic Pediococcus acidilactici on piglet intestine, circulating lymphocytes, aspects performance during first 42 days after weaning. Sixteen female piglets were at weaning assigned two groups:...
Aim: Adipose-derived stem cells (ASCs) have been deeply characterized for their usefulness in musculoskeletal tissue regeneration; recently, other mesenchymal cell (MSC) sources also proposed. This study compares the first time human tendon stem/progenitor isolated from hamstring tendons with ASCs. Materials & Methods: Human TSPCs and ASCs were portions adipose of healthy donors undergoing ACL reconstruction or liposuction, respectively (n = 7). Clonogenic ability, immunophenotype...
A novel three-dimensional bicomponent substitute made of collagen type I and hydroxyapatite was tested for the repair osteochondral lesions in a swine model. This scaffold assembled by newly developed method that guarantees strict integration between organic inorganic parts, mimicking biological tissue chondral osseous phase. Thirty-six were created trochlea six pigs; each pig, two treated with scaffolds seeded autologous chondrocytes (cell+group), unseeded (cell− group), remaining left...
The meniscus plays important roles in knee function and mechanics is characterized by a heterogeneous matrix composition. changes vascularization observed during growth suggest that the tissue-specific composition may be result of maturation process. This study has aim to characterize structural biochemical variations occur swine with age. To this purpose, menisci were collected from young adult pigs divided into different zones. In 1, both lateral medial anterior horn, body posterior horn...
Recent advances in animal nutrition have indicated that bovine colostrum (BC), due to its content of macronutrients, micronutrients and bioactive compounds, is an excellent health supplement. To the best our knowledge, no studies on effect BC antioxidant status been performed rabbits. This study aimed investigate two concentrations gene expression enzymes some tissues Thirty New Zealand White male rabbits were randomly divided into three experimental diets, containing 0% (CON), 2.5%, 5%...
Musculoskeletal impairments, especially cartilage and meniscus lesions, are some of the major contributors to disabilities. Thus, novel tissue engineering strategies being developed overcome these issues. In this study, aim was investigate biocompatibility, in vitro vivo, a thermosensitive, injectable chitosan-based hydrogel loaded with three different primary mesenchymal stromal cells. The cell types were human adipose-derived cells (hASCs), bone marrow stem (hBMSCs), neonatal porcine...
Abstract Meniscal lesions in vascularized regions are known to regenerate while lack of vascular supply leads poor healing. Here, we developed and validated a novel methodology for three‐dimensional structural analysis meniscal structures with high‐resolution microcomputed tomography (µCT). We collected porcine medial menisci from 10 neonatal (not‐developed meniscus, n‐) adults (fully a‐). The were cut into anatomical (anterior horn (n‐AH a‐AH), central body (n‐CB a‐CB), posterior (n‐PH...