Melike Fırlak

ORCID: 0000-0003-1674-9086
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Research Areas
  • Analytical Chemistry and Sensors
  • Electrochemical sensors and biosensors
  • Hydrogels: synthesis, properties, applications
  • Molecular Sensors and Ion Detection
  • Conducting polymers and applications
  • Adsorption and biosorption for pollutant removal
  • Analytical chemistry methods development
  • Advanced Sensor and Energy Harvesting Materials
  • Extraction and Separation Processes
  • Recycling and Waste Management Techniques
  • Synthesis and properties of polymers
  • Effects and risks of endocrine disrupting chemicals
  • Advanced Polymer Synthesis and Characterization
  • Advancements in Transdermal Drug Delivery
  • Flame retardant materials and properties
  • Polymer Surface Interaction Studies
  • Synthesis and characterization of novel inorganic/organometallic compounds
  • Photopolymerization techniques and applications
  • Advanced Drug Delivery Systems
  • Silk-based biomaterials and applications
  • Graphene and Nanomaterials Applications
  • Building materials and conservation
  • Covalent Organic Framework Applications
  • Advanced biosensing and bioanalysis techniques
  • Biochemical and Structural Characterization

Gebze Technical University
2020-2025

Lancaster University
2018-2023

Marmara University
2009-2018

Altınbaş University
2013-2016

For some professionally, vocationally, or technically oriented careers, curricula delivered in higher education establishments may focus on teaching material related to a single discipline. By contrast, multidisciplinary, interdisciplinary, and transdisciplinary (MITT) results improved affective cognitive learning critical thinking, offering learners/students the opportunity obtain broad general knowledge base. Chemistry is discipline that sits at interface of science, technology,...

10.1021/acs.jchemed.0c01363 article EN Journal of Chemical Education 2021-03-04

The delivery of drugs in a controllable fashion is topic intense research activity both academia and industry because its impact healthcare. Implantable electronic interfaces for the body have great potential positive economic, health, societal impacts; however, implantation such results inflammatory responses due to mechanical mismatch between inorganic substrate soft tissue, also microbial infection during complex surgical procedures. Here, we report use conducting polypyrrole (PPY)-based...

10.3390/ma11071123 article EN Materials 2018-07-01

Abstract In this study, experimental measurements have been made on the batch adsorption of cadmium and lead ions from aqueous solutions using poly(guanidine modified 2‐acrylamido‐2‐methylpropan sulfonic acid/acrylic acid/ N ‐vinylpyrrolidone/2‐Hydroxyethyl methacrylate), P(AMPSG/AAc/NVP/HEMA) hydrogels. The guanidyl end group bearing AMPSG monomer was synthesized reaction AMPS guanidine. hydrogels were prepared by UV‐curing technique. morphology dry H10‐hydrogel sample examined SEM....

10.1002/pat.1554 article EN Polymers for Advanced Technologies 2009-09-18

Abstract In this study, photocured a novel thiol‐ene hydrogels based on P(Penta3MP4/PEG‐DA/HEMA) were investigated for adsorption of Au(III) ions from aqueous solutions purposes. The photopolymerization kinetics thiol‐ene‐based formulations was by real‐time infrared spectroscopy. chemical composition and surface morphology also characterized. effect different parameters efficiency examined in detail. Better behavior achieved F1 hydrogels. maximum uptake at pH 0.5. Both Langmuir Freundlich...

10.1002/app.36887 article EN Journal of Applied Polymer Science 2012-03-30

Abstract Biomaterials capable of controlling the delivery drugs have potential to treat a variety conditions. Herein, preparation electrically conductive silk fibroin film‐based drug devices is described. Casting aqueous solutions Bombyx mori fibroin, followed by drying and annealing impart β‐sheets assure that materials are stable for further processing in water; films rendered generating an interpenetrating network copolymer pyrrole 3‐amino‐4‐hydroxybenzenesulfonic acid matrix...

10.1002/mame.202000130 article EN cc-by Macromolecular Materials and Engineering 2020-05-17

Abstract The development of stimuli‐responsive drug delivery systems offers significant opportunities for innovations in industry. It is possible to produce polymer‐based devices enabling spatiotemporal control the release triggered by an electrical stimulus. Here we describe a wireless controller from conductive/electroactive biomaterials and demonstrate its function vitro . polymer conduction device uses very low power, operating at 2.4 GHz, has supply voltage circuit which controls...

10.1002/pi.6089 article EN cc-by Polymer International 2020-07-20

In this present work, we reported the adsorption and recovery studies of a P(Penta3MP4/PEG-DA/HEMA) thiol-ene based hydrogel. Real-time infrared spectroscopy technique was used to identify photopolymerization kinetics formulations. The chemical composition surface morphology hydrogels were also characterized. influence conditions such as pH, hydrogel formulations, contact time, initial metal ion concentration, foreign ions on binding capacity hydrogel, tested. Both Langmuir Freundlich...

10.1080/01496395.2013.811692 article EN Separation Science and Technology 2013-08-27

The CRISPR-Cas9 system has facilitated the genetic modification of various model organisms and cell lines. outcomes any assay should be investigated to ensure/improve precision genome engineering. In this study, carbon nanotube-modified disposable pencil graphite electrodes (CNT/PGEs) were used develop a label-free electrochemical nanogenosensor for detection point mutations generated in by using system. Carbodiimide chemistry was immobilize 5′-aminohexyl-linked inosine-substituted probe on...

10.3390/bios11010017 article EN cc-by Biosensors 2021-01-08

The release of metformin, a drug used in the treatment cancer and diabetes, from poly(2-hydroxyethyl methacrylate), pHEMA, hydrogel-based microneedle patches is demonstrated vitro. Tuning composition pHEMA hydrogels enables preparation robust with mechanical properties such that they would penetrate skin (insertion force single to be ≈40 N). Swelling experiments conducted at 20, 35, 60 °C show temperature-dependent degrees swelling diffusion kinetics. Drug microneedles fitted various models...

10.1002/gch2.202300002 article EN cc-by Global Challenges 2023-07-05

Abstract The uniform porous and continuous phase lead (II) adsorbent hydrogel, was prepared by copolymerizing 2-hydroxyethyl methacrylate (HEMA), acrylic acid (AAc), N,N′-methylenebisacrylamide (MBAAm), with n-vinyl imidazole (VIM). A series of hydrogels, including different ratios VIM, were photopolymerization characterized. influence the uptake conditions such as pH, functional monomer percent, contact time, initial feed concentration, foreign metal ions on ion binding capacity also...

10.1080/01496395.2011.579080 article EN Separation Science and Technology 2011-05-11

A new thiourea and urea functional monomers were synthesized. series of hydrogels prepared by photopolymerization. The used for the removal Pb(II) Cd(II) ions from aqueous solutions. influence uptake conditions such as pH, time, initial feed concentration on metal ion binding capacity hydrogel was tested. selectivity towards different also adsorption isotherm models applied. limits detection quantification calculated. usability preconcentration studies investigated.

10.1080/01496390903256208 article EN Separation Science and Technology 2009-12-31

Electroactive hydrogels based on derivatives of polyethyleneglycol (PEG), chitosan and polypyrrole were prepared via a combination photopolymerization oxidative chemical polymerization, optionally doped with anions (e.g., lignin, drugs, etc.). The products analyzed variety techniques, including: FT-IR, UV-Vis, 1H NMR (solution state), 13C (solid XRD, TGA, SEM, swelling ratios rheology. conductive gels swell ca. 8 times less than the non-conductive due to presence interpenetrating network...

10.3390/polym14224953 article EN Polymers 2022-11-16

In situ forming hydrogels are a class of biomaterials that can fulfil variety important biomedically relevant functions and hold promise for the emerging field patient-specific treatments (e.g., cell therapy, drug delivery). Here we report results our investigations on generation in with potential wound healing applications complex blast injuries). The combination polysaccharides were oxidized to display aldehydes, amine displaying chitosan nanostructured ZnO yields bionanocomposite...

10.3390/jfb10040050 article EN cc-by Journal of Functional Biomaterials 2019-11-14

The development of electrochemical stimuli-responsive drug delivery systems is both academic and industrial interest due to the ease with which it possible trigger payload release, providing in a controllable manner. Herein, preparation situ forming hydrogels including electroactive polypyrrole nanoparticles (PPy-NPs) where Sr2+ ions are electrochemically loaded for electrically triggered release reported. were characterized by variety techniques Fourier-transform infrared (FTIR)...

10.1039/d3ra07061a article EN cc-by RSC Advances 2024-01-01

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10.2139/ssrn.4737688 preprint EN 2024-01-01
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