A5108046395- Immune cells in cancer
- Nosocomial Infections in ICU
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Dendrimers and Hyperbranched Polymers
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- Reproductive System and Pregnancy
- Extracellular vesicles in disease
- Cancer Cells and Metastasis
- Mesenchymal stem cell research
Karolinska Institutet
2021-2024
Karolinska University Hospital
2021-2024
Cihan University-Erbil
2021
Abstract Haematopoiesis dysregulation with the presence of immature myeloid and erythroid immunosuppressive cells are key characteristics immune escape phase tumour development. Here, role in vitro generated B16F10 cell‐derived extracellular vesicles (tEVs) as indirect cellular communicators, participating tumour‐induced haematopoiesis, was explored. The isolated tEVs displayed features small EVs a size range 100–200 nm, expressed common EV markers CD63, CD9, Alix, had spherical shape lipid...
Non-viral transfection reagents are continuously being developed in attempt to replace viral vectors. Among those non-viral vectors, dendrimers have gained increasing interest due their unique molecular structure and multivalency. However, more improvements still needed achieve higher efficacy lower toxicity. In this study, we examined 18 peptide conjugated lipophilic moieties, such as fatty acids or hydrophobic amino acids, that were previously explored for siRNA. Reporter cells employed...
The immune escape stage in cancer immunoediting is a pivotal feature, transitioning immune-controlled tumor dormancy to progression, and augmenting invasion metastasis. Tumors employ diverse mechanisms for escape, with generating immunosuppressive cells from skewed hematopoiesis being crucial mechanism. This led us suggest that properties produce factors induce dysregulations hematopoiesis. In support of this suggestion, study found mice bearing advanced-stage tumors exhibited dysregulated...