A5033068685- Osteoarthritis Treatment and Mechanisms
- Extracellular vesicles in disease
- Knee injuries and reconstruction techniques
- Mesenchymal stem cell research
- Bone Tissue Engineering Materials
- MicroRNA in disease regulation
- Mycobacterium research and diagnosis
- Natural product bioactivities and synthesis
- Dermatologic Treatments and Research
- Bone and Joint Diseases
- Inflammatory mediators and NSAID effects
- Laser Applications in Dentistry and Medicine
- Modular Robots and Swarm Intelligence
- Proteoglycans and glycosaminoglycans research
- Curcumin's Biomedical Applications
- Micro and Nano Robotics
- Bone and Dental Protein Studies
- Bone health and treatments
- Chemokine receptors and signaling
- Periodontal Regeneration and Treatments
- Advanced Sensor and Energy Harvesting Materials
- Bone Metabolism and Diseases
- Silk-based biomaterials and applications
- Pharmaceutical and Antibiotic Environmental Impacts
- Protein Hydrolysis and Bioactive Peptides
Chonnam National University Hospital
2017-2025
Chonnam National University Hwasun Hospital
2017-2025
Chonnam National University
2017
Targeted cell delivery by a magnetically actuated microrobot with porous structure is promising technique to enhance the low targeting efficiency of mesenchymal stem (MSC) in tissue regeneration. However, relevant research performed date only its proof-of-concept stage. To use clinical stage, biocompatibility and biodegradation materials should be considered microrobot, efficacy needs verified using an vivo model. In this study, we propose human adipose-derived MSC-based medical system for...
Osteoarthritis (OA) is a chronic musculoskeletal disorder characterized by cartilage degeneration and synovial inflammation. Paracrine interactions between chondrocytes macrophages play an essential role in the onset progression of OA. In this study, replicating inflammatory response during OA pathogenesis, were treated with interleukin-1β (IL-1β), lipopolysaccharide interferon-γ. addition, coculture system was developed to simulate biological situation joint. we examined impact hyaluronic...
A bone-remodeling imbalance induced by increased bone resorption and osteoclast formation causes skeletal diseases such as osteoporosis. Induction of osteogenic differentiation marrow stromal cells (BMSCs) leads to regeneration. Many researchers have tried develop new adjuvants specific stimulators regeneration for therapeutic use in patients with resorption. We a adjuvant that has stronger differentiation-promoting activity than morphogenetic proteins (BMPs). In this study, we identified...
Osteoarthritis (OA) is a degenerative joint disorder that distinguished by inflammation and chronic cartilage damage. Interleukin-1β (IL-1β) proinflammatory cytokine plays an important role in the catabolic processes underlie pathogenesis of OA. In this study, we investigate therapeutic efficacy exosomes derived from untreated bone-marrow-derived mesenchymal stem cells (BMMSC-Exo) those treated with cinnamaldehyde (BMMSC-CA-Exo) for preventing vitro effects IL-1β on chondrocytes. We...
Bone morphogenetic proteins (BMPs) have been widely used as treatment for bone repair. However, clinical trials on fracture repair challenged the effectiveness of BMPs and suggested that delivery multipotent marrow stromal cells (BMSCs) might be beneficial. During remodeling repair, BMSCs differentiate into osteoblasts or chondrocytes to stimulate formation regeneration. Stem cell-based therapies provide a promising approach formation. Extensive research has attempted develop adjuvants...
Mesenchymal stem cells (MSCs) rely on chemokines and chemokine receptors to execute their biological physiological functions. Stromal cell-derived factor-1 (SDF-1) is upregulated in injury sites, where it acts as a chemotactic agent, attracting CXCR4-expressing MSCs, which play pivotal role the healing regeneration of tissue throughout body. Furthermore, SDF-1 expression has been observed regions experiencing inflammation-induced bone destruction fracture sites. In this study, we identified...
Inflammatory disorders encompass a range of conditions, including osteoarthritis (OA), characterized by the body's heightened immune response to diverse stimuli. OA is prevalent degenerative joint disease progressive deterioration cartilage and subchondral bone, leading pain, limited mobility, physical disability. Synovitis, inflammation synovial membrane, increasingly recognized as critical factor in pathogenesis progression. This study evaluates therapeutic potential cinnamaldehyde (CA),...
녹농균은 특히 면역이 저하된 환자에게서 심각한 감염을 일으키는 그람음성의 기회감염 균주이다. 또한 carbapenem 내성 metallo-<TEX>${\beta}$</TEX>-lactamases (MBL)를 가진 녹농균이 한국에서 증가되는 추세로 보고되고 있다. 따라서 본 실험에서는 2차 병원인 삼육 서울 병원에서 수집된 총 92종의 임상 녹농균의 다재내성 수준을 분석하였다. 항생제에 대한 감수성은 최소억제농도(MIC) 분석에 의해 결정되었고, inhibitor-potentiated disk diffusion(IPD) 분석은 MBL 검출을 위해 수행되었다. RAPD-PCR은 임상환자에서 분리한 녹농균 계통의 유전적 유형의 특징을 밝히기 사용되었다. 그 결과 임상에서 분리된 40.2%는 ceftazidime에 내성을, 58.7%는 meropenem에 56.5%는 gentamicin에 46.7%는 tobramycin에 62.0%는 ciprofloxacin에 내성을 그리고...