A5031338961- Micro and Nano Robotics
- Soft Robotics and Applications
- Gastrointestinal Bleeding Diagnosis and Treatment
- Molecular Communication and Nanonetworks
- Modular Robots and Swarm Intelligence
- Advanced Sensor and Energy Harvesting Materials
- Microfluidic and Bio-sensing Technologies
- Robotic Mechanisms and Dynamics
- Teleoperation and Haptic Systems
- Advanced Surface Polishing Techniques
- Dielectric materials and actuators
- Advanced Materials and Mechanics
- Gastrointestinal disorders and treatments
- 3D Printing in Biomedical Research
- Robot Manipulation and Learning
- Characterization and Applications of Magnetic Nanoparticles
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Piezoelectric Actuators and Control
- Iterative Learning Control Systems
- Manufacturing Process and Optimization
- Prosthetics and Rehabilitation Robotics
- Wireless Power Transfer Systems
- Intracranial Aneurysms: Treatment and Complications
- Underwater Vehicles and Communication Systems
Chonnam National University
2014-2023
Inha University
2023
Dong-A University
2002-2020
Dong A University
2020
Gachon University
2017
Chonnam National University Hospital
2014-2016
Soongeui Women's College
2016
Gwangju University
2016
Government of the Republic of Korea
2016
Korea Aerospace Research Institute
2002-2011
For drug delivery in cancer therapy, various stimuli-responsive hydrogel-based micro-devices have been studied with great interest. Here, we present a new concept for hybrid actuated soft microrobot targeted delivery. The proposed consists of hydrogel bilayer structure 2-hydroxyethyl methacrylate (PHEMA) and poly (ethylene glycol) acrylate (PEGDA) iron (II, III) oxide particles (Fe3O4). PHEMA layer as pH-responsive gel is used trapping unfolding motion the pH-varying solution,...
We propose a bacteria-based microrobot (bacteriobot) based on new fusion paradigm for theranostic activities against solid tumors. develop bacteriobot using the strong attachment of bacteria to Cy5.5-coated polystyrene microbeads due high-affinity interaction between biotin and streptavidin. The chemotactic responses bacteriobots concentration gradients lysates or spheroids tumors can be detected as migration and/or out central region toward side regions in microfluidic chamber. showed...
Targeted cell delivery by a magnetically actuated microrobot with porous structure is promising technique to enhance the low targeting efficiency of mesenchymal stem (MSC) in tissue regeneration. However, relevant research performed date only its proof-of-concept stage. To use clinical stage, biocompatibility and biodegradation materials should be considered microrobot, efficacy needs verified using an vivo model. In this study, we propose human adipose-derived MSC-based medical system for...
Microrobots that can be precisely guided to target lesions have been studied for in vivo medical applications. However, existing microrobots challenges such as biocompatibility, biodegradability, actuation module, and intra- postoperative imaging. This study reports visualized with real-time x-ray magnetic resonance imaging (MRI) magnetically tumor feeding vessels transcatheter liver chemoembolization vivo. The microrobots, composed of a hydrogel-enveloped porous structure nanoparticles,...
Owing to the limitations of conventional flexible endoscopes used in gastrointestinal diagnostic procedures, which cause discomfort and pain patients, a wireless capsule endoscope has been developed commercialized. Despite many advantages endoscope, its restricted mobility limited use diagnosis esophagus small intestine only. Therefore, extend range into stomach colon, additional mobility, such as 3-D locomotion, steering is necessary. Previously, several researchers reported on development...
Nanorobots are safe and exhibit powerful functionalities, including delivery, therapy, diagnosis. Therefore, they in high demand for the development of new cancer therapies. Although many studies have contributed to progressive nanorobot system anticancer drug these systems still face some critical limitations, such as potentially toxic materials nanorobots, unreasonable sizes passive targeting, lack several essential functions delivery sensing, active controlling release, sufficient loading...
Toward wireless medical microrobot applications driven by an electromagnetic actuation (EMA) system, challenges associated with movability, the force, and coil system size must be addressed. This paper presents enhanced EMA a higher magnetic field via new configurations, independent control method, application to multi-degree-of-freedom (DOF) motion of untethered capsule endoscope. The magnetically actuated endoscope (MACE) proposed herein consists endoscopic permanent magnet in body, eight...
Exosomes are nanosized extracellular vesicles secreted by various cell types, including those of the immune system, such as natural killer (NK) cells. They play a role in intercellular communication transporting signal molecules between Recent studies have reported that NK cell-derived exosomes (NK-exo) contain cytotoxic proteins-induced death. However, characteristics and potential functions NK-exo, especially for liver cancer poorly understood. In this study, we investigated anti-tumor...
Wearable biosensors have the potential for developing individualized health evaluation and detection systems owing to their ability provide continuous real-time physiological data. Among various wearable biosensors, localized surface plasmon resonance (LSPR)-based sensors can be versatile in practical applications sensitive interactions with specific analytes. Understanding analyzing endocrine responses stress is particularly crucial evaluating human performance, diagnosing stress-related...
This study proposes a magnetically actuated microscaffold with the capability of targeted mesenchymal stem cell (MSC) delivery for articular cartilage regeneration. The microscaffold, as 3D porous microbead, is divided into body and surface portions according to its materials fabrication methods. body, which consists poly(lactic‐co‐glycolic acid) (PLGA), formed through water‐in‐oil‐in‐water emulsion templating, coated amine functionalized magnetic nanoparticles (MNPs) via amino bond...
We described a magnetic chitosan microscaffold tailored for applications requiring high biocompatibility, biodegradability, and monitoring by real-time imaging. Such microscaffolds exhibit adjustable pores sizes depending on the target application provide various functions such as actuation enhanced cell adhesion using biomaterial-based particles. Subsequently, we fabricated with optimized shape pore properties to specific diseases. As versatile tool, capability of developed was demonstrated...
Stomach cancer is a global health concern as millions of cases are reported each year. In the present study, we developed pH-responsive microrobot with good biocompatibility, magnetic-field controlled movements, and ability to be visualized via X-ray imaging. The consisted composite resin layer. This was found fold itself in high pH environments unfold low environments. addition, neodymium (NdFeB) magnetic nanoparticles inside provided an by field through electromagnetic actuation system,...
Recently, the capsule endoscope can be widely used for diagnosis of digestive organs. It is passively moved by peristaltic waves gastro-intestinal tract and thus has some limitations doctor to get image organ diagnose more thoroughly. As a solution these problems, therefore, locomotive mechanism endoscopes being developed. Our proposed capsule-type microrobot synchronized multiple legs that are actuated linear actuator two mobile cylinders inside capsule. By novel kinematic relation between...
Recently, coronary artery disease such as angina pectoris and myocardial infarction has become the major causes of death. As a method medical treatment for disease, pharmacological approaches surgical operations are executed. Especially, percutaneous intervention (PCI) using catheters mostly preferred diseases. The PCI technologies advanced various useful devices developed utilized. However, some clinical chronic total occlusion (CTO) remain limitation challenge. robot-assisted...