A5013672271- Immune Response and Inflammation
- Immune responses and vaccinations
- Phagocytosis and Immune Regulation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Vibrio bacteria research studies
Imperial College London
2019
Shigella flexneri is historically regarded as the primary agent of bacillary dysentery, yet closely-related sonnei replacing S. flexneri, especially in developing countries. The underlying reasons for this dramatic shift are mostly unknown. Using a zebrafish (Danio rerio) model infection, we discover that more virulent than vivo. Whole animal dual-RNAseq and testing bacterial mutants suggest virulence depends on its O-antigen oligosaccharide (which unique among species). We show vivo using...
Abstract Shigella flexneri is historically regarded as the primary agent of bacillary dysentery, yet closely-related sonnei replacing S. , especially in developing countries. The underlying reasons for this dramatic shift are mostly unknown. Using a zebrafish ( Danio rerio ) model infection, we discover that more virulent than vivo . Whole animal dual-RNAseq and testing bacterial mutants suggest virulence depends on its O-antigen oligosaccharide (which unique among species). We show using ex...