A5033915566- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nutrition and Health Studies
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Valve Diseases and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Phytoestrogen effects and research
- Natural Antidiabetic Agents Studies
- Blood Coagulation and Thrombosis Mechanisms
- Pregnancy and preeclampsia studies
- Systemic Lupus Erythematosus Research
- Cardiovascular Function and Risk Factors
- Pharmaceutical Economics and Policy
- Lipid metabolism and disorders
- Atherosclerosis and Cardiovascular Diseases
- Paraoxonase enzyme and polymorphisms
- Inflammatory Bowel Disease
- Exercise and Physiological Responses
- Cardiovascular Issues in Pregnancy
- Cholesterol and Lipid Metabolism
- Coronary Interventions and Diagnostics
- Chemotherapy-induced cardiotoxicity and mitigation
- Extracellular vesicles in disease
- Vitamin K Research Studies
Gdańsk Medical University
2016-2025
University Clinical Centre
2020
Medical University of Warsaw
2018-2019
Jagiellonian University
2018
Lipoprotein(a) [Lp(a)] is made up of a low-density lipoprotein (LDL) particle and specific apolipoprotein(a). The blood concentration Lp(a) approximately 90% genetically determined, the main genetic factor determining levels size apo(a) isoform, which determined by number KIV2 domain repeats. isoform inversely proportional to Lp(a). strong independent cardiovascular risk factor. Elevated ≥ 50 mg/dl (≥ 125 nmol/l) are estimated occur in more than 1.5 billion people worldwide. However,...
Abstract Lipoprotein apheresis (LA) is a therapeutic option for hyperlipoproteinemia(a) (hyper-Lp(a)) and atherosclerotic cardiovascular disease (ASCVD). LA improves blood rheology, reduces oxidative stress parameters endothelial function. The underlying molecular mechanisms of beneficial effects are unknown, but it has been suggested that exhibits multiple activities beyond simply removing lipoproteins. We hypothesized removes not only lipoproteins, also extracellular vesicles (EVs). To...
The bicuspid aortic valve (BAV) is commonly associated with the early degeneration of valve. Up to 45% BAV patients over age 50 develop stenosis (AS). Although published data indicate a robust interplay between lipids and calcific AS in tricuspid patients, studies on population are lacking. We aimed evaluate association selected lipid markers occurrence patients. Methods: study included 76 adults (21 female) diagnosed by echocardiography, divided diagnosis. Biochemical parameters...
Introduction We aimed to assess the usefulness of lipoprotein(a) [Lp(a)] and LDL-C levels as potential predictors coronary lesions' complexity in patients with premature artery disease (pCAD). Methods This study enrolled 162 consecutive pCAD undergoing angiography. The SYNTAX score (SS) was used complexity. Linear discriminant analysis (LDA) employed construct a multivariate classification model enabling prediction SS. Results Lp(a) among SS ≥ 23 1-22 were significantly higher than those = 0...
Background: Oxidative stress and dyslipidemia play a critical role in the development of cardiovascular disease (CVD). Regular intake polyphenol-rich diets is associated with reduced risk CVDs. Methods: The present study was pilot 24 healthy volunteers designed to determine if 12-week administration Cistus incanus herbal tea, containing phenolic acids flavonoids, reduces factors including oxidative adults. Phenolic compounds profile antibacterial activity infusion were also measured....
Hypercholesterolemia-associated oxidative stress increases the formation of oxidized low-density lipoprotein (oxLDL), which can affect endothelial cell function and potentially contribute to renal dysfunction, as reflected by changes in urinary protein excretion. This study aimed investigate impact exogenous oxLDL on excretion albumin nephrin. LDL was isolated from a patient with familial hypercholesterolemia (FH) undergoing apheresis (LA) vitro Cu (II) ions. Biochemical markers oxidation,...
Being rich in polyunsaturated fatty acids, flaxseed (Linum usitatissimum L.) is thought to be able decrease lipid levels and dampen inflammation. In this pilot study, we aimed determine whether supplementation could improve the profiles of lipids inflammatory mediators patients with severe hyperlipidemia resistant conventional lipid-lowering pharmacotherapy requiring lipoprotein apheresis. To end, six received, blindly—in addition their normal apheresis regimen—a 10-week dietary (28 g/d)...
In chronic kidney disease (CKD), the level of high-density lipoprotein (HDL) decreases markedly, but there is no strong inverse relationship between HDL-cholesterol (HDL-C) and cardiovascular diseases. This indicates that not only HDL-C level, also other quantitative changes in HDL particles can influence protective functionality these particles, play a key role increase risk CKD patients. The aim present study was evaluation parameters may give additional information about course...
Background: The monogenic defect in familial hypercholesterolemia (FH) is detected ∼40% of cases. majority mutation-negative patients have a polygenic cause high LDL-cholesterol (LDL-C). We sought to investigate whether the underlying or associated with response rosuvastatin. Methods: FH Individuals were tested for mutations LDLR and APOB genes. A previously established LDL-C-specific risk score (PRS) was used examine possibility patients. All received rosuvastatin they followed 8 ± 2...
Background: The carotid intima–media thickness (IMT) measurement may be carried out proximally (pIMT) or distally (dIMT) in relation to the bulb of common artery which has significant implications on results and correlation with risk factors. aim study was compare pIMT dIMT patients familial hypercholesterolemia confirmed by genetic testing (FH group) severe non-familial hypercholesterolemia, negative (NFH determine traditional atherosclerotic factors calcium scores. Methods: A total 86 FH...
Abstract Objectives Low-density lipoprotein cholesterol (LDL-C) is the main laboratory parameter used for management of cardiovascular disease. The aim this study was to compare measured LDL-C with as calculated by Friedewald, Martin/Hopkins, Vujovic, and Sampson formulas regard triglyceride (TG), non-high-density (non-HDL-C)/TG ratio. Methods 1,209 results were compared using ultracentrifugation-precipitation (first study) direct (second methods. Passing-Bablok regression applied percentage...
Food Effect on LDL-C Foods high in n-6 PUFA and/or MUFA and low SFA; e.g., canola oil Moderate to large reduction soluble fiber; psyllium, oats, barley with added plant sterols or stanols Flaxseeds (whole) Small moderate Soy protein Tomatoes Almonds Fish No clear effect Decaffeinated coffee (in place of regular coffee) Filtered SFA trans fatty acids (i.e., solid tropical fats) increase Unfiltered filtered Avocados Turmeric Hazelnuts Pulses Green tea At least small Fiber, whole grains Walnuts...
Background: Severe familial hypercholesterolemia (FH) individuals, refractory to conventional lipidlowering medications are at exceptionally high risk of cardiovascular events. The established therapeutic option last choice is lipoprotein apheresis (LA). Herein, it was sought investigate the clinical usefulness LA in a highly selected group severe heterozygous FH (HeFH), as recently described by International Atherosclerosis Society (IAS), for their efficacy lipid reduction and safety....
Lipoprotein apheresis (LA) treatment results in a substantial reduction of low-density lipoprotein- (LDL-) cholesterol and lipoprotein(a) concentrations, which consequently decreases the rate cardiovascular events. The additional benefit LA may be associated with its impact on composition quality high-density lipoprotein (HDL) particles, inflammation, oxidative stress condition. To verify effects procedure, current study is aimed at analyzing effect single procedure direct hemadsorption...
Lipoprotein X (LpX) is an abnormal lipoprotein fraction, which can be detected in patients with severe hypercholesterolaemia and cholestatic liver disease. LpX composed largely of phospholipid free cholesterol, small amounts triglyceride, cholesteryl ester protein. There are no widely available methods for direct measurement routine laboratory practice. We present the heterogeneity clinical manifestations presence LpX, a phenomenon hinders detection.The study was conducted on 26-year-old...
Abstract Background Lipoprotein apheresis (LA) is a safe method of reducing atherogenic lipoproteins and improving cardiovascular (CV) outcomes. We aimed to assess the reductions in low‐density lipoprotein cholesterol (LDL‐C) (a) [Lp(a)] levels patients undergoing regular LA therapy evaluate its influence on incidence rate adverse cardiac vascular events (ACVE) major (MACE). Methods A longitudinal study Poland evaluated prospective retrospective observational data 23 with...
We aimed to compare the extent of subclinical atherosclerosis in ascending and descending aortas by measuring wall area thickness using 3D cardiovascular magnetic resonance imaging (aAWAI dAWAI) patients with asymptomatic familial hypercholesterolemia (FH) nonfamilial (NFH). also establish interrelations CMR parameters other measurements, such as calcium scores, obtained computed tomography coronary arteries (CCS) aorta (TCSasc TCSdsc), well carotid intima-media thicknesses (cIMT)...
Abstract Introduction High blood levels of lipoprotein(a) [Lp(a)] were suggested to increase the risk preeclampsia. Because excessive coagulation is involved in preeclampsia and Lp(a) a known pro-coagulative protein, hypothesis that causally seems be consistent. Nevertheless, exact impact causal role on was not well elucidated. are widely recognized highly genetics-dependent, we chose Mendelian Randomization [MR] as tool determine incidence Purpose To whether have Methods A two-sample MR...
BackgroundLipoprotein apheresis (LA) is an extracorporeal treatment that transiently reduces lipoprotein (a) by 60% and leads to 80–92% reduction in major adverse cardiovascular events. LA has a significant impact on lipid profile serum of patients with atherosclerotic disease.ObjectiveTo investigate the effects composition fatty acids (FAs), focusing those which could have disease (CVD).MethodsThis prospective study First Department Cardiology Medical University Gdansk, Poland. Serum...
Bicuspid aortic valve (BAV) affects 0.5-2% of the general population and constitutes major cause severe stenosis (AVS) in individuals ≤70 years. The aim present study was to evaluate parameters that may provide information about risk AVS developing BAV patients, with particular emphasis on lipoprotein(a) (Lp(a)), which is a well-recognized factor for population. We also analyzed impact autotaxin (ATX) interleukin-6 (IL-6) as potentially related pathomechanism Lp(a) action. found high levels...
Background Preeclampsia is a common and serious pregnancy-induced disease, with potential severe maternal fetal complications. Recently, an increased lipoprotein (a) (Lp[a]) concentration, important factor in cardiovascular diseases (CVDs) pathogenesis, has been identified as sensitive specific marker of preeclampsia severity. Although apheresis (LA) currently used patients hyperlipoproteinemia(a) CVD, real-life data on its efficacy among pregnant women risk are limited. Case presentation We...