A5030498127- Acute Ischemic Stroke Management
- Venous Thromboembolism Diagnosis and Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Multiple Sclerosis Research Studies
- Advanced Neuroimaging Techniques and Applications
- Bone and Joint Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebral Palsy and Movement Disorders
- Peripheral Artery Disease Management
- Osteoarthritis Treatment and Mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Balance, Gait, and Falls Prevention
- Systemic Lupus Erythematosus Research
- Hip disorders and treatments
- Knowledge Management and Sharing
- Gastrointestinal motility and disorders
- Retinal Imaging and Analysis
- Malaria Research and Control
- Effects of Vibration on Health
- Global Maternal and Child Health
- Cerebral Venous Sinus Thrombosis
- Neurosurgical Procedures and Complications
- Mosquito-borne diseases and control
- Lower Extremity Biomechanics and Pathologies
Washington University in St. Louis
2017-2024
Massachusetts General Hospital
2022-2024
Harvard University
2024
Stanford University
2021-2023
Central Michigan University
2023
Mayo Clinic
2023
WinnMed
2023
Medical College of Wisconsin
2023
Mayo Clinic in Arizona
2023
University of Cambridge
2020
<h3>BACKGROUND AND PURPOSE:</h3> Cortical venous outflow has emerged as a robust measure of collateral blood flow in acute ischemic stroke. The addition deep drainage to this assessment may provide valuable information further guide the treatment these patients. <h3>MATERIALS METHODS:</h3> We performed multicenter retrospective cohort study patients with stroke treated by thrombectomy between January 2013 and 2021. internal cerebral veins were scored on scale 0–2. This metric was combined...
Abstract Gait impairments in persons with multiple sclerosis (pwMS) leading to decreased ambulation and reduced walking endurance remain poorly understood. Our objective was assess gait asymmetry (GA) bilateral coordination of (BCG), among pwMS during the six-minute walk test (6MWT), determine their association disease severity. We recruited 92 (age: 46.6 ± 7.9; 83% females) a range clinical disability, who completed 6MWT wearing analysis system. GA assessed by comparing left right swing...
Abstract Objective Multiple sclerosis (MS) lesions are heterogeneous with regard to inflammation, demyelination, axonal injury, and neuronal loss. We previously developed a diffusion basis spectrum imaging (DBSI) technique better address MS lesion heterogeneity. hypothesized that the profiles of multiple DBSI metrics can identify lesion‐defining patterns. Here we test this hypothesis by combining deep learning algorithm using neural network (DNN) other methods. Methods Thirty‐eight patients...
To investigate whether unfavorable cerebral venous outflow (VO) predicts reperfusion hemorrhage after endovascular treatment (EVT), we conducted a retrospective multicenter cohort study of patients with acute ischemic stroke and large vessel occlusion (AIS-LVO). 629 AIS-LVO met inclusion criteria. VO profiles were assessed on admission CT angiography using the Cortical Vein Opacification Score (COVES). Unfavorable was defined as COVES ≤ 2. Reperfusion hemorrhages follow-up imaging subdivided...
Previous randomized controlled trials (RCTs) and meta-analyses were underpowered to demonstrate the superiority of endovascular thrombectomy (EVT) over medical therapy (MEDT) in treatment acute ischemic stroke due large vessel occlusion posterior circulation (PC-LVO). We performed an updated systematic review meta-analysis after publication BAOCHE ATTENTION determine whether EVT can benefit patients presenting with PC-LVO.Using Nested Knowledge, we screened literature for RCTs on PC-LVO. The...
Parenchymal hematoma (PH) is a major complication after endovascular treatment (EVT) for ischemic stroke. The hypoperfusion intensity ratio (HIR) represents perfusion parameter reflecting arterial collateralization and cerebral microperfusion in brain tissue. We hypothesized that HIR correlates with the risk of PH EVT. Retrospective multicenter cohort study patients large vessel occlusion who underwent EVT between 2013 2021 at one 2 comprehensive stroke centers (University Medical Center...
The standard functional tool for gait assessment in multiple sclerosis (MS) clinical trials has been the 25-Foot Timed Walk Test, a measure of speed. Straight-line may not reflect adequately upon balance and coordination. Walking tests with turns add additional information towards understanding status, be more reflective ambulation community. Understanding impact turn parameters on patient-reported outcomes walking would help MS clinicians better formulate treatment plans persons...
Robust venous outflow (VO) profiles, measured by degree of opacification on pre-thrombectomy CT angiography (CTA) studies, are strongly correlated with favorable outcomes in patients large vessel occlusion acute ischemic stroke treated thrombectomy. However, VO measurements laborious and require neuroimaging expertise.
Performance tests are important to characterize patient disabilities and functional changes. The Osteoarthritis Research Society International others recommend the 30-second Chair Stand Test Stair Climb Test, among others, as core that capture two distinct types of disability during activities daily living. However, these limited by current protocols testing in clinics. There is a need for an alternative allows remote capabilities osteoarthritis population.Objectives (1) develop app...
AimTo investigate the current prevalence and management of dyspepsia in rural Eastern Uganda.MethodsResidents older than 18 years age across 95 study sites Namutumba District, Uganda were surveyed. Each respondent was administered a questionnaire about pertinent health-seeking behaviors. Health workers at 12 different clinics also assessed on their competence managing dyspepsia. Proportion-based analysis used to determine self-reported outcome variables reported this study, including:...