Axel Spahr

ORCID: 0000-0003-1714-5727
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About
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Research Areas
  • Oral microbiology and periodontitis research
  • Periodontal Regeneration and Treatments
  • Bone and Dental Protein Studies
  • Endodontics and Root Canal Treatments
  • Dental Health and Care Utilization
  • dental development and anomalies
  • Dental materials and restorations
  • Oral and gingival health research
  • HIV/AIDS oral health manifestations
  • Dental Radiography and Imaging
  • Orthodontics and Dentofacial Orthopedics
  • Oral Health Pathology and Treatment
  • Salivary Gland Disorders and Functions
  • Dental Implant Techniques and Outcomes
  • Dental Research and COVID-19
  • Bone Tissue Engineering Materials
  • Helicobacter pylori-related gastroenterology studies
  • Dental Trauma and Treatments
  • NMR spectroscopy and applications
  • Oral and Maxillofacial Pathology
  • Veterinary medicine and infectious diseases
  • Gastric Cancer Management and Outcomes
  • Vitamin D Research Studies
  • Fatty Acid Research and Health
  • Advanced MRI Techniques and Applications

The University of Sydney
2016-2025

Sydney Dental Hospital
2016-2024

Westmead Institute
2024

Sydney South West Area Health Service
2016

Aristotle University of Thessaloniki
2016

Euro-Mediterranean University of Fes
2011

Universität Ulm
1999-2010

University Hospital Ulm
2002-2003

<h3>Background</h3> Chronic inflammation from any source is associated with increased cardiovascular risk. Periodontitis a possible trigger of chronic inflammation. We investigated the association between periodontitis and coronary heart disease (CHD), focusing on microbiological aspects. <h3>Methods</h3> A total 789 subjects (263 patients angiographically confirmed, stable CHD 526 population-based, age- sex-matched controls without history CHD) were included in Coronary Event Periodontal...

10.1001/archinte.166.5.554 article EN Archives of Internal Medicine 2006-03-13

The precise mode of transmission and the natural reservoir for Helicobacter pylori are unknown. PCR assays have proved to be highly sensitive specific regarded as method choice detecting H. DNA in oral cavity. aim this study was investigate prevalence distribution Forty-two patients undergoing gastroscopy were investigated presence dental plaque saliva by nested PCR, stomach 13C-urea breath test. Samples tested comprised from molars, premolars incisors saliva. Two sets primers homologous...

10.1099/0022-1317-49-4-349 article EN Journal of Medical Microbiology 2000-04-01

To attain a collective expert opinion on the use of air powder waterjet technology (APWT) with erythritol and glycine powders in prophylaxis therapy periodontal peri-implant diseases.

10.1002/cre2.855 article EN cc-by Clinical and Experimental Dental Research 2024-02-01

Abstract Objectives: Various surgical techniques have been proposed for coverage of denuded root surfaces. The aim this study was to evaluate a comparison coronally repositioned flap procedure with or without the use enamel matrix proteins in treatment recession defects. Material and methods: This an intra‐individual longitudinal test 12 months duration conducted as blinded, split‐mouth, placebo‐controlled randomised design. It performed 2 dental schools. 36 patients, aged 22–62 years,...

10.1034/j.1600-051x.2002.290106.x article EN Journal Of Clinical Periodontology 2002-01-01

Abstract Objectives: The aim of this study was to evaluate the effect Emdogain ® (EMD), used for periodontal regeneration, on growth pathogens like Actinobacillus actinomycetemcomitans , Porphyromonas gingivalis and Prevotella intermedia. For comparison, we studied EMD several microbes associated with other oral diseases as well its non‐pathogenic inhabitants. Methods: Freshly prepared or vehicle propylene glycol alginate (PGA) alone were added calibrated suspensions microbes. As a control,...

10.1034/j.1600-051x.2002.290110.x article EN Journal Of Clinical Periodontology 2002-01-01

Background: The aim of this study was to evaluate a comparison the coronally advanced flap procedure with or without use enamel matrix proteins in treatment recession defects. Methods: This 2‐year conducted as blinded, split‐mouth, placebo‐controlled, and randomized design. Thirty patients from two dental schools paired buccal defects were chosen. Surgical coverage performed technique. One site additionally treated derivative (EMD) other placebo (propylene glycol alginate [PGA]). A blinded...

10.1902/jop.2005.76.11.1871 article EN Journal of Periodontology 2005-11-01

Abstract The objective of this study was to investigate the potential ultra short echo time imaging for assessment caries lesions and early demineralization. 12 patients with suspected underwent a dental magnetic resonance investigation comprising (echo = 50 μs) spin imaging. Before imaging, all conventional clinical including visual teeth as well x‐ray All identifiable in could be clearly identified images, but only about 19% were visible images. In lesions, more delineated images than This...

10.1002/mrm.22828 article EN Magnetic Resonance in Medicine 2011-02-28

Background: Dietary fibre plays a crucial role in metabolic regulation, inflammation, and microbiome composition. However, its impact on systemic oral health, particularly periodontitis, remains unclear. This study investigated the effects of high- low-fibre diets body composition, glycaemic control, microbiome, metabolome murine model experimental periodontitis. Methods: Thirty-six male C57BL/6 mice were randomised to high-fibre (40% fibre) or (5% diet for eight weeks. Body weight, fat...

10.3390/nu17071146 article EN Nutrients 2025-03-26

Ameloblastin (AMBN) was originally believed to be an enamel‐specific extracellular matrix glycoprotein secreted by ameloblasts. Recently, AMBN expression also detected in developing mesenchymal dental hard tissues, trauma‐induced reparative dentin, and during early craniofacial bone formation. The function structure of still remain ambiguous, there are no known proteins with similar primary sequences. We therefore performed a bio‐informatic analysis model ab initio the three‐dimensional...

10.1111/j.1600-0722.2008.00526.x article EN European Journal Of Oral Sciences 2008-03-18

Based on previous results showing the expression of ameloblastin (Ambn; amelin) in formation mesenchymal dental hard tissues, we investigated its presence during bone development. Immunohistochemistry (IHC), situ hybridization (ISH), and reverse transcription–polymerase chain reaction (RT–PCR) were used to investigate protein mRNA craniofacial development rats. Tissue samples collected embryonic day 18 from days 2–28 postnatally. IHC revealed at early postnatal stages with different patterns...

10.1111/j.1600-0722.2006.00403.x article EN European Journal Of Oral Sciences 2006-12-01

Tamburstuen MV, Reppe S, Spahr A, Sabetrasekh R, Kvalheim G, Slaby I, Syversen U, Lyngstadaas SP, Reseland JE. Ameloblastin promotes bone growth by enhancing proliferation of progenitor cells and stimulating immunoregulators. Eur J Oral Sci 2010; 118: 451–459. © 2010 In this study, we examined the role enamel matrix protein, ameloblastin, in remodelling, attempted to identify some molecular mechanisms involved these processes. The effects recombinant ameloblastin (rAmbn) were tested vivo...

10.1111/j.1600-0722.2010.00760.x article EN European Journal Of Oral Sciences 2010-08-16

Abstract Aim To assess the efficacy of adjunct use a subgingival erythritol powder air‐polishing device (EPAP) in comparison to conventional instrumentation alone during initial non‐surgical periodontal therapy. Materials and Methods Twenty‐one patients with generalized Stages 2 3 grade B periodontitis were included this single centre, blinded, split‐mouth, randomized clinical trial. Teeth on control side treated hand ultrasonic instrumentation, while those contralateral test was using EPAP...

10.1111/jcpe.13623 article EN Journal Of Clinical Periodontology 2022-04-04

Recent studies have indicated that cementum formation can be induced when dental follicular cells are exposed to enamel matrix. The purpose of the present investigation was study this and appearance involved, including their expression collagen types alpha1(I), alpha1(II) alpha1(III) mRNAs, during process by means light microscopy in situ hybridisation. mandibular first molars 5-d-old rats were surgically taken out, epithelium removed, then crowns re-inserted with occlusal surface downwards...

10.1046/j.0909-8836.1999.eos107507.x article EN European Journal Of Oral Sciences 1999-10-01
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