A5086455677- Pharmaceutical and Antibiotic Environmental Impacts
- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Wastewater Treatment and Reuse
- Fecal contamination and water quality
- Molecular Biology Techniques and Applications
- Ethics in Clinical Research
- Analytical chemistry methods development
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial biofilms and quorum sensing
- Gut microbiota and health
- Water Treatment and Disinfection
TU Dresden
2016-2021
Norsk Hydro (Germany)
2018-2019
The antibiotic resistome in European UWTPs mirrors the gradient of north-to-south clinical resistance prevalence.
There is increasing public concern regarding the fate of antibiotic resistance genes (ARGs) during wastewater treatment, their persistence treatment process and potential impacts on receiving water bodies. In this study, we used quantitative PCR (qPCR) to determine abundance nine ARGs a class 1 integron associated integrase gene in 16 plant (WWTP) effluents from ten different European countries. order assess impact bodies, abundances latter were also analysed. Six out analysed detected all...
To test the hypothesis of a seasonal relationship antibiotic prescriptions for outpatients and abundance resistance genes (ARGs) in wastewater, we investigated distribution different ARGs Dresden sewer system wastewater treatment plant during two-year sampling campaign. Based on quantitative PCR (qPCR), our results show clear pattern relative abundances. The higher levels autumn winter coincide with rates overall prescriptions. While no significant differences abundances were observed before...
Treated wastewater (TWW) irrigation is a useful counter-measure against the depletion of freshwater (FW) resources. However, TWW contains several contaminants emerging concern, such as antibiotic resistant bacteria (ARB) and genes (ARGs). Thus, might promote spread antimicrobial resistance in soil environments. In present work, we hypothesized that ARG load intensity define effect on dynamics soil. This hypothesis was tested using multiphase approach: a) comparing from full-scale,...
Integrons are extensively targeted as a proxy for anthropogenic impact in the environment. We developed novel high-throughput amplicon sequencing pipeline that enables characterization of thousands integron gene cassette-associated reads, and applied it to acquire comprehensive overview cassette composition effluents from wastewater treatment facilities across Europe. Between 38 100 172 995 reads per-sample were generated functionally characterized by screening against nr, SEED, ARDB...
Treated wastewater irrigation (TWW) releases antibiotics and antibiotic resistance genes (ARGs) into the environment might thus promote dissemination of in groundwater (GW). We hypothesized that TWW increases ARG abundance GW through two potential mechanisms: contamination with resistant bacteria accumulation GW. To test this, below a real-scale TWW-irrigated field was sampled for six months. Sampling took place before, during after high-intensity irrigation. Samples were analysed 16S rRNA...
In the present study, we investigated impact of treated wastewater (TWW) irrigation on prevalence antibiotic resistance genes (ARGs) in subsoil pore-water, a so-far under-appreciated matrix. We hypothesized that TWW increases ARG pore-water. This hypothesis was tested using multiphase approach, which consisted sampling percolated pore-water from lysimeter-wells real-scale TWW-irrigated field, operated for commercial farming practices, and controlled, laboratory microcosms irrigated with...
Abstract In the present study, we investigated impact of treated wastewater (TWW) irrigation on prevalence antibiotic resistance genes (ARGs) in subsoil pore-water, a so-far under-appreciated matrix. We hypothesized that TWW increases ARG pore-water. This hypothesis was tested using multiphase approach, which consisted sampling percolated pore-water from lysimeter-wells real-scale TWW-irrigated field, operated for commercial farming practices, and controlled, laboratory mesocosms irrigated...