A5034407625- Pharmaceutical and Antibiotic Environmental Impacts
- Antibiotic Resistance in Bacteria
- Gut microbiota and health
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Use and Resistance
- Microbial Community Ecology and Physiology
- Research studies in Vietnam
- Streptococcal Infections and Treatments
- Tuberculosis Research and Epidemiology
- Bacterial biofilms and quorum sensing
- Mycobacterium research and diagnosis
- Biochemical and Structural Characterization
- Wastewater Treatment and Nitrogen Removal
- Composting and Vermicomposting Techniques
- Clostridium difficile and Clostridium perfringens research
- Bee Products Chemical Analysis
- Aquaculture disease management and microbiota
- Innovative Educational Techniques
- Infective Endocarditis Diagnosis and Management
- Genomics and Phylogenetic Studies
- Infections and bacterial resistance
- Cultural Heritage Materials Analysis
- Cancer therapeutics and mechanisms
- Neonatal and Maternal Infections
- Anaerobic Digestion and Biogas Production
National University of Ireland, Maynooth
2017-2024
Ho Chi Minh City University of Technology and Education
2017-2024
Taras Shevchenko National University of Kyiv
2020
Ho Chi Minh City University of Culture
2020
University of Zielona Góra
2020
Institute for Computational Science and Technology
2017
University of California, San Francisco
2010-2016
Centro Nacional de Biotecnología
2011
A comprehensive monitoring of a broad set antibiotics in the final effluent wastewater treatment plants (WWTPs) 7 European countries (Portugal, Spain, Ireland, Cyprus, Germany, Finland, and Norway) was carried out two consecutive years (2015 2016). This is first study this kind performed at an international level. Within 53 monitored 17 were detected least once WWTPs, i.e.: ciprofloxacin, ofloxacin, enrofloxacin, orbifloxacin, azithromycin, clarithromycin, sulfapyridine, sulfamethoxazole,...
The antibiotic resistome in European UWTPs mirrors the gradient of north-to-south clinical resistance prevalence.
Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is epidemic in the United States, even rivaling HIV/AIDS its public health impact. The pandemic clone USA300, like other CA-MRSA strains, expresses Panton-Valentine leukocidin (PVL), a pore-forming toxin that targets polymorphonuclear leukocytes (PMNs). PVL thought to play key role pathogenesis of necrotizing pneumonia, but data from rodent infection models are inconclusive. Rodent PMNs less susceptible than human...
Staphylococcus aureus is a Gram-positive, commensal bacterium known to asymptomatically colonize the human skin, nares, and gastrointestinal tract. Colonized individuals are at increased risk for developing S. infections, which range from mild skin soft tissue infections more severe diseases, such as endocarditis, bacteremia, sepsis, osteomyelitis. Different virulence factors required infect different body sites. In this study, gene expression was analyzed in two isolates during nasal...
Abstract Water quality testing does not recognise antimicrobial resistance (AMR) and is often limited to indicators of faecal contamination Escherichia coli Enterococcus species. In Europe, data on AMR in drinking water scarce. Ireland, as many countries, household supplied via mains or private wells schemes. Using citizen science, we identified Irish supplies reservoirs resistant bacteria (ARB). Gram-negative ( n = 464) Gram-positive 72) were isolated. We instances potentially opportunistic...
Human intravenous immunoglobulin contains specific antitoxin antibodies that protect against necrotizing pneumonia caused by MRSA in a rabbit model.
Direct application of pig slurry to agricultural land, as a means nutrient recycling, introduces pathogens, antibiotic resistant bacteria, or genes, the environment. With global environmental sustainability policies mandating reduction in synthetic fertilisation and commitment circular economy it is imperative find effective on-farm treatments that maximises its value minimises risk health We assessed compared effect storage, composting, anaerobic digestion (AD) on microbiome, resistome...
BackgroundRifampicin is an important first-line antibiotic for the treatment of mycobacterial infections. Although most rifampicin-resistant strains arise through mutations in rpoB gene bacteria, a proportion such show no mutations. This suggests that alternative mechanisms are responsible rifampicin resistance.
Background. Detailed knowledge on protein repertoire of a pathogen during host infection is needed for both developing better understanding the pathogenesis and defining potential therapeutic targets. Such data, however, have been missing Staphylococcus aureus, major human pathogen.
There is little known about the wastewater treatment plant (WWTP) effluent microbiome, its structure and dynamics. Here, we provide a study of microbiome leaving conventional WWTPs entering water environment. DNA was extracted from WWTP samples collected in 2015 2016. The bacterial communities were studied using Illumina MiSeq 16S rRNA gene amplicon sequencing analysed Calypso software. Proteobacteria, Bacteroides, Actinobacteria, Firmicutes, Tenericutes Verrucomicrobia phyla dominated...
Wastewater treatment plants (WWTPs) provide optimal conditions for the maintenance and spread of antibiotic resistant bacteria (ARB) resistance genes (ARGs). In this work we describe occurrence faecal coliforms their mechanisms in effluent two urban WWTPs Ireland. This information is critical to identifying role dissemination ARB ARGs into environment. Effluent samples were collected from Spring Autumn 2015 2016. The bacterial susceptibility patterns 13 antibiotics determined. phenotypic...
Grasslands cover a large proportion of global agricultural landmass used to feed herbivores and ruminants link the environment food chain via animals onto humans. However, most scientific studies antimicrobial resistance microbiomes at environmental - animal nexus have focused on soil or vegetables rather than grasslands. Based previous microbiome phyllosphere-soil we hypothesised that resistomes across grass would core shared taxa genes (ARGs), but in addition each also minority unique...
Within the past decade, microbiologists have moved from detecting single antibiotic resistance genes (ARGs) to all known within a sample due advances in next generation sequencing. This has provided wealth of data on variation and relative abundances ARGs present total bacterial population. However, use these terms therapy or risk patients, they must be analyzed context background microbiome. Using quantitative PCR ARG chip 16S rRNA amplicon sequencing, we sought identify bacteria fecal...
Abstract Plasmids play a crucial role in the spread of antimicrobial resistance genes (ARGs) across One Health due to their ability transfer wide range ARGs within and bacterial species biomes. We sequenced 173 circularised plasmids transferred from wastewater treatment plant (WWTP) effluent into Escherichia coli subsequently characterised genetic content. Multiple multidrug resistant were identified with significant number mega (>100Kb). existing isolation rare almost all existed other...
Rifampicin is a critical first-line antibiotic for treating mycobacterial infections such as tuberculosis, one of the most serious infectious diseases worldwide. resistance in mycobacteria mainly caused by mutations rpoB gene; however, some rifampicin-resistant strains showed no mutations. Therefore, alternative mechanisms must explain this mycobacteria. In work, library 11,000 Mycobacterium smegmatis mc2 155 insertion mutants was explored to search and characterize new rifampicin-resistance...
Since the beginning of COVID-19 pandemic, online learning has become more popular and challenging in panorama higher education Vietnam.However, there still been very little research strongly focusing on lived experiences learners, especially English-major students Vietnamese universities.In this paper, I retold process my students" collaborative autobiographical narrative inquiry into their under impacts pandemic at a technology university southern Vietnam.My wonders came from two questions:...
Phương pháp xây dựng mô hình sản phẩm lý tưởng (IPM) dựa trên giả định có mối liên hệ giữa điểm ưa thích một với khoảng cách cường độ cảm nhận và tưởng. Theo này, càng đi lệch khỏi của nó thì thấp. Nghiên cứu này được thực hiện mục đích bia lon lager đối người tiêu dùng trẻ. Các mẫu sử dụng trong nghiên là năm bán thị trường Việt Nam. 104 tham gia thí nghiệm đánh giá mười hai thuộc tính. Dữ liệu phân tích tính nhất quán quan khoái cùng bản đồ cho (Ideal Map). Kết quả thu giúp các đơn vị xuất...
Nghiên cứu này sử dụng colchicine để tạo dòng bạch đàn lai đa bội phục vụ cho chương trình cải thiện giống trồng rừng gỗ lớn ở Việt Nam. Thí nghiệm được tiến hành trên 2 UP54 và UP99 do Viện NC Giống CNSH Lâm nghiệp chọn tạo. Vật liệu thí là đoạn thân mang mắt ngủ của cây in vitro xử lý đột biến bằng dung dịch các nồng độ 0% (đối chứng); 0,25; 0,5 0,75% trong thời gian 1,2,3,4 5 ngày. Kết quả thấy: đối với UP54, 0,5% 3 ngày thích hợp nhất tứ tỉ lệ 33,33%; UP99, 0,25% 4 24%. Quan sát hình...
Antibiotic resistance is regarded as one of the most serious threats to human health worldwide. The rapid increase in rates has been attributed extensive use antibiotics since they became commercially available. growth promotors banned numerous regions for this reason. Mannan-rich fraction (MRF) reported show similar growth-promoting effects antibiotics. We investigated effect MRF on microbial community, resistome and metabolic pathways within caecum commercial broilers at two different...
Extended-spectrum β-lactamase (ESBL)/AmpC producing bacteria are one of the critical priority resistant that contributes to treatment failure and increased death rates. In this work we aimed study role wastewater plants (WWTPs) as reservoirs ESBL/AmpC faecal coliforms. The effluent samples were collected from two WWTPs coliforms isolated all using membrane filtration method. Bacterial isolates subjected antimicrobial susceptibility testing toward cefotaxime ceftazidime. showed a resistance...
Abstract Wastewater treatment plants (WWTPs) provide optimal conditions for the maintenance and spread of antibiotic resistant bacteria (ARB) resistance genes (ARGs). In this work we describe occurrence faecal coliforms their mechanisms in effluent two urban WWTPs Ireland. Effluent samples were collected from Spring Autumn 2015 2016. The bacterial susceptibility patterns to 13 antibiotics determined. phenotypic tests carried out identify AmpC or extended-spectrum β-lactamase (ESBL)...