A5022482310- Pharmaceutical and Antibiotic Environmental Impacts
- Antibiotic Resistance in Bacteria
- Microbial Community Ecology and Physiology
- Gut microbiota and health
- Wastewater Treatment and Nitrogen Removal
- Antibiotics Pharmacokinetics and Efficacy
- Evolution and Genetic Dynamics
- Water Treatment and Disinfection
- Antibiotic Use and Resistance
- Chromium effects and bioremediation
- Environmental DNA in Biodiversity Studies
- Evolutionary Game Theory and Cooperation
- Aquaculture disease management and microbiota
- Ethics in Clinical Research
- Constructed Wetlands for Wastewater Treatment
- Bacteriophages and microbial interactions
- Vibrio bacteria research studies
- CRISPR and Genetic Engineering
- Bacterial biofilms and quorum sensing
- Heavy metals in environment
- Wastewater Treatment and Reuse
- Marine Invertebrate Physiology and Ecology
- Microbial Metabolic Engineering and Bioproduction
- Genomics and Phylogenetic Studies
- Microplastics and Plastic Pollution
TU Dresden
2020-2025
Institute of Hydrobiology, Biology Centre, Academy of Sciences of the Czech Republic
2024-2025
Norsk Hydro (Germany)
2022-2023
University of Exeter
2018-2022
Royal Cornwall Hospital
2018-2020
University of Warwick
2020
University of Hong Kong
2017
Technical University of Denmark
2013-2016
Wastewater treatment plants (WWTPs) are a source and reservoir for subsequent spread of various antibiotic resistance genes (ARGs). However, little is known about the activity hosts ARGs in WWTPs. Here, we utilized both metagenomic metatranscriptomic approaches to comprehensively reveal diversity, abundance, expression activated sludge (AS) from three conventional WWTPs Taiwan. Based on deep sequencing data custom-made ARG database, total 360 associated with 24 classes antibiotics were...
Abstract Antibiotic resistance has emerged as one of the most pressing, global threats to public health. In single-species experiments selection for antibiotic occurs at very low concentrations. However, it is unclear how far these findings can be extrapolated natural environments, where species are embedded within complex communities. We competed isogenic strains Escherichia coli, differing exclusively in a single chromosomal determinant, presence and absence pig faecal microbial community...
Abstract When antimicrobial resistant bacteria (ARB) and genes (ARGs) reach novel habitats, they can become part of the habitat’s microbiome in long term if are able to overcome biotic resilience towards immigration. This process should more difficult with increasing biodiversity, as exploitable niches a given habitat reduced for immigrants when diverse competitors present. Consequently, microbial diversity could provide natural barrier resistance by reducing persistence time immigrating ARB...
Microplastic pollution is increasingly considered to be a factor of global change: in addition aquatic ecosystems, this persistent contaminant also found terrestrial systems and soils. Microplastics have been chiefly examined soils terms the presence potential effects on soil biota. Given persistence widespread distribution microplastics, it important consider evolutionary implications microplastics soil; we offer such perspective for microbiota. We discuss range selection pressures likely...
Complete ammonia oxidizers (comammox), able to individually oxidize nitrate, are considered play a significant role in the global nitrogen cycle. However, distribution of comammox Nitrospira estuarine tidal flat wetland and environmental drivers affecting their abundance diversity remain unknown. Here, we present large-scale investigation on geographical along wetlands China, where were successfully detected 9 16 sampling sites. The ranged from 4.15 × 105 6.67 106 copies/g, 2.21- 5.44-folds...
Treated wastewater (TWW) irrigation is a useful counter-measure against the depletion of freshwater (FW) resources. However, TWW contains several contaminants emerging concern, such as antibiotic resistant bacteria (ARB) and genes (ARGs). Thus, might promote spread antimicrobial resistance in soil environments. In present work, we hypothesized that ARG load intensity define effect on dynamics soil. This hypothesis was tested using multiphase approach: a) comparing from full-scale,...
Antibiotic resistance is one of the major problems facing medical practice in 21st century. Historical approaches to managing antibiotic have often focused on individual patients, specific pathogens and particular phenotypes. However, it increasingly recognized that a complex ecological evolutionary problem. As such, understanding dynamics requires integration data diverse mobile genetic elements associated with genes, their dissemination by various mechanisms horizontal gene transfer...
Horizontal gene transfer (HGT) plays a critical role in the spread of antibiotic resistance and evolutionary shaping bacterial communities. Conjugation is most well characterized pathway for resistance, compared to transformation transduction. While antibiotics have been found induce HGT, it remains unknown whether non-antibiotic pharmaceuticals can facilitate conjugation at microbial community-wide level.In this study, we demonstrate that several commonly consumed (including carbamazepine,...
River microbial communities regularly act as the first barrier of defense against spread antimicrobial resistance genes (ARGs) that enter environmental microbiomes through wastewater. However, how invasion dynamics wastewater-borne ARGs into river biofilm will shift due to climate change with increasing average and peak temperatures remains unknown. Here, we aimed elucidate effects on naturally occurring resistome, well success foreign entering Natural biofilms were grown in a...
InfoMetricsFiguresRef. Environmental Science & TechnologyASAPArticle This publication is Open Access under the license indicated. Learn More CiteCitationCitation and abstractCitation referencesMore citation options ShareShare onFacebookX (Twitter)WeChatLinkedInRedditEmailJump toExpandCollapse ViewpointJanuary 28, 2025Strengthening Policy Relevance of Wastewater-Based Surveillance for Antimicrobial ResistanceClick to copy article linkArticle link copied!Sheena Conforti*Sheena ConfortiEawag,...
Antimicrobial resistance (AMR) and smoking of tobacco products are two the most important threats to global human health. Both associated with millions deaths every year. Surprisingly, immediate interactions between these yet poorly understood.
Microbial communities derived from soils subject to different agronomic treatments were challenged with three broad host range plasmids, RP4, pIPO2tet and pRO101, via solid surface filter matings assess their permissiveness. Approximately 1 in 10 000 soil bacterial cells could receive maintain the plasmids. The community permissiveness increased up 100% manured soil. While plasmid transfer frequency was significantly influenced by both type of treatment, diversity transconjugal pools purely...
Treated wastewater irrigation (TWW) releases antibiotics and antibiotic resistance genes (ARGs) into the environment might thus promote dissemination of in groundwater (GW). We hypothesized that TWW increases ARG abundance GW through two potential mechanisms: contamination with resistant bacteria accumulation GW. To test this, below a real-scale TWW-irrigated field was sampled for six months. Sampling took place before, during after high-intensity irrigation. Samples were analysed 16S rRNA...
Antimicrobial resistance (AMR) genes are often carried on broad host range plasmids, and the spread of AMR within microbial communities will therefore depend structure bacteria–plasmid networks. Empirical theoretical studies ecological interaction networks suggest that network differs between predominantly mutualistic versus antagonistic, with former showing more generalized interactions (i.e., species interact many others to a similar extent). This suggests networks—where antibiotics...
Plasmids are key disseminators of antimicrobial resistance genes and virulence factors, it is therefore critical to predict reduce plasmid spread within microbial communities. The cost carriage a metric that can be used plasmids' ecological fate, unclear whether costs affected by growth partners in community. We carried out competition experiments tracked maintenance using model system consisting synthetic stable five-species community broad host-range plasmid, engineered carry different...
Selection for antibiotic resistance at very low concentrations has been demonstrated individual antibiotics in single species experiments. Furthermore, selection these focal strains is reduced when taking place complex microbial community context. However, the environment, bacteria are rarely exposed to single, but rather mixtures of selective agents. Here, we explored how presence a second agent affects dynamics between isogenic pairs E. coli strains, differing exclusively determinant,...