Inflammation and increased oxidative stress in testicular tissue are documented side effects of torsion the testicles. The preventive role Bromelain (Bro) against testicle torsion-induced ischemia/reperfusion (I/R) injury was investigated this research. Five groups six animals each were created: ischemia, Ischemia+Reperfusion (I+R), Ischemia+Reperfusion+Bromelain (I+R+Bro; 10 mg/kg), control (sham), (Bro; mg/kg). An I/R damage resulted from two hours 720° clockwise twisting left testis....

Doxorubicin (DOX) is the most used chemotherapeutic agent for treating solid tumors. DOX treatment may lead to testicular damage using oxidative stress, resulting in infertility. These adverse effects be prevented by activation of antioxidant systems. Oleuropein (OLE) a powerful flavonoid with several ameliorative effects, including antioxidative, antiproliferative, and anti-inflammatory. It would more efficient applicable chronic human diseases if its poor bioavailability improves...

Abstract Metformin is commonly prescribed to people with diabetes. has been shown in previous studies be able prevent the growth of cancer cells. This study aims investigate effects metformin and gold nanoparticles MCF7 breast A549 lung cell lines. The on cells were determined grown 24 h culture. MCF-7 incubated for treatment escalating molar concentrations ifosfamide. MTT assay was used determine cytotoxicity toward expression Bax, BCL2, PI3K, Akt3, mTOR, Hsp60, Hsp70, TNF-α measured by...

Sepsis is a life-threatening condition characterized by systemic inflammatory response to infection. Despite extensive research on its pathophysiology, effective therapeutic approaches remain challenge. This study investigated the potential of resveratrol (RV) and silver nanoparticle-enhanced (AgNP-RV) as treatments for sepsis-induced lung injury using rat model polymicrobial sepsis induced cecal ligation puncture (CLP). The focused evaluating changes in oxidative status (TAS, TOS, OSI)...

Diabetes mellitus (DM) is a metabolic disorder that occurs as result of absolute or relative insufficiency insulin release and/or effect due to impairment carbohydrate, fat and protein metabolism, it characterized by hyperglycemia leads various complications.In this study, was aimed investigate the effects hesperidin (HP) quercetin, which are natural flavonoids, on serum malondialdehyde (MDA), glutathione (GSH), tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6) levels in rats with...

Abstract Acute lung injury (ALI) is a severe respiratory disorder associated with high morbidity and mortality. Lipopolysaccharide (LPS) widely used to induce ALI in animal models. D-carvone, natural monoterpene, has been reported possess anti-inflammatory antioxidant properties. This study aimed investigate the protective effects of D-carvone on LPS-induced rats. Thirty-six male rats were randomly divided into six groups ( n = 6): control, (10 mg/kg 20 p.o.), LPS E. coli lipopolysaccharide...

The aim of this study was to investigate the effects red dragon fruit (Hylocereus polyrhizus) extract (DFE) on stomach in ulcer model induced by indomethacin rats. Effects DFE were evaluated indomethacin-induced gastric damage Sprague–Dawley Experimental model: all rats fasted for 24 h. At end period, administered ulcer-induced groups. One hour after application, a dose 25 mg/kg applied oral gavage groups except HEALTHY and DFE1000 Six hours administration, euthanized with high-dose...

Objective: Lithium is an element denoted by the symbol Li in periodic table. salts are widely used worldwide as therapeutic agents treatment of excitement. However, use lithium causes liver damage. Carvone unsaturated monoterpenoid ketone usually found essential oil extracts aromatic medicinal plants such dill, mint, and cumin. Various studies have shown that D-Carvone has strong antioxidant anti-inflammatory effects. In this study, it was aimed to investigate protective effect D-carvone on...

Abstract This study aimed to present new data on the side effects of favipiravir healthy lung tissue and respiratory system. In study, two different durations (5 10 days) were preferred determine effect treatment due clinical improvement rates approximately 5 days during use in COVID‐19 patients. addition, after treatment, animals kept for without any regeneration tissues. Favipiravir was administered rats by oral gavage at a daily dose 200 mg/kg days, as previous studies. At end experiment,...

Lipopolysaccharide (LPS) is an endotoxin found in the wall of gram-negative bacteria and causes acute inflammation when it enters tissues. 18β-glycyrrhetinic acid (18β-GA) a substance licorice root responsible for this plant's antiallergic, antioxidant, anti-inflammatory activity. This study aimed to examine possible effects on damage caused by LPS kidney tissue. The divided 40 Sprague Dawley adult male rats into 5 equal groups (n = 8). were created as follows; control group; group that...

This study aimed to investigate the protective effects of gallic acid (GA) against ovarian damage induced by bisphenol A (BPA) exposure in female rats. We evaluated whether GA can mitigate adverse BPA on structure, inflammatory markers, oxidative stress, apoptosis, and reproductive hormone levels.

We thought that astaxanthin (ASX) might be a protective agent in oxidative stress damage develops against ischemia and reperfusion injury the rat ovary.The experimental groups consisted of healthy, I (Ischemia), I+ASX50, I+ASX100, I/R (Ischemia/Reperfusion), I/R+ ASX50, ASX100. Vascular clamps were applied to ovaries for 3 hr induce ischemia. For groups, opened blood flow was restored hr. At end experiment, biochemical, histopathological, immunohistochemical analyses made from tissue samples...

This study aimed to investigate hypothyroidism's effects on endometrial receptivity, creating an experimental hypothyroidism model in female rats.To induce rats of Hipotiroid-ER and Treatment-ER groups, 0.05% 6-propyl-2-thiouracil was freshly added their drinking water for 8 weeks then the receptivity applied sacrificed fifth day. In group, after sc-administration 0.8 µg/100 g L-thyroxine 10 days, day.In histopathological evaluation, epithelial degeneration, vacuolization, enlargement...

Antiseptic agents used in the postoperative period affect functions of many tissues body, including testicles. In this study, effect dressings administered with different antiseptic on testicular rats that underwent abdominal incisions was investigated. A total 48 Sprague-Dawley were study. Each study group a 4 cm-long skin and muscle operation. The incision then stitched immediately. Antiseptics, hemp seed oil, leaf cannabidiol oil to for 10 days provide antisepsis. sacrificed 24 hours...

Colorectal cancer (CRC) continues to be one of the most prevalent malignancies worldwide, necessitating innovative therapeutic interventions. This study aims elucidate combinatorial effects chemotherapeutic agent Cetuximab (CTX) and antidepressant agomelatine on expression levels key genes in CACO-2 human colon cell line. The PI3K/Akt/mTOR signaling pathway, integral various physiological processes, was primarily investigated, revealing significant modulations upon drug treatments. Notably,...

In this study, histopathological and immunohistochemical evaluations were made on the damage to gastric tissue in peptic ulcer model induced by indomethacin, it was investigated whether plants Hypericum perforatum Rosa spinosissima have a therapeutic effect. order create an model, 25mg/kg indomethacin administered orally rats other groups, except sham control group, 2 doses, 24 hours apart. treatment first dose of given hour after second dose, plant oils later. Then, 1 later, sacrificed....

Mevcut çalışmanın amacı; kemoterapötik olarak kullanılan 5-FU’nun akciğerlerde oluşturduğu hasara karşı doğal flavonoidlerden olan naringinin koruyucu etkilerini araştırmaktır. Çalışmada 200-250 g ağırlığında, 30 adet Sprague Dawley cinsi erkek rat kullanıldı. Ratlar rastgele seçilerek Kontrol grubu, 5-FU grubu ve NA+5-FU ayrıldı. 5-Fluorouracilin akciğer dokularında interstisyel fibrozis konjesyona, alveoller arası septumda yangısal hücre infiltrasyonuna bağlı kalınlaşma, peribronşiyal...

Purpose: In this study, our aim was to investigate the potential effects of strong antioxidant daidzein (DZ) on ovarian ischemia and reperfusion injury.
 Materials Methods: A total 42 female Sprague-Dawley rats were randomly divided into seven groups. For experimental model, clamps removed after 3 hours ischemia, blood flow provided again. Then, process terminated for hours. Daidzein orally administered animals at doses 35 70 mg/kg 30 minutes before (I) (I/R) procedures.
 Results:...

Titanium is the most widely used metal for bone integration, especially cancer patients receiving ionizing radiation. This study aimed to investigate amifostine administration that would reduce effects of radiation on healing and osseointegration in rat models.It application rats radiotherapy treatment will negative bone.Thirty-five adult male Wistar were randomly divided into one healthy four experimental groups. In three consecutive days, two groups (AMF-RT-IMP RT-IMP) exposed (15 Gy/3...