Sepsis is a life-threatening condition characterized by systemic inflammatory response to infection. Despite extensive research on its pathophysiology, effective therapeutic approaches remain challenge. This study investigated the potential of resveratrol (RV) and silver nanoparticle-enhanced (AgNP-RV) as treatments for sepsis-induced lung injury using rat model polymicrobial sepsis induced cecal ligation puncture (CLP). The focused evaluating changes in oxidative status (TAS, TOS, OSI)...

Abstract Chronic stress is linked to changes in brain physiology and functioning, affects the central nervous system (CNS), causes psychiatric diseases such as depression anxiety. In this study, antidepressant effects of probiotic bacterium Lactobacillus rhamnosus GG (ATCC 53103) (LGG) (15 × 10 8 cfu/ml/day) on mechanisms playing a role pathophysiology were investigated, results compared with bupropion (20 mg/kg/day) venlafaxine mg/kg/day). A total 56 male Wistar Albino rats used control,...

ABSTRACT Introduction Injuries to the recurrent laryngeal nerve (RLN) that may occur during thyroidectomy cause hoarseness, dysphagia, and dyspnea. Even if injured can be repaired surgically, it heals slowly not completely. Platelet‐rich plasma (PRP) is obtained by centrifuging blood taken from human body. PRP accelerates healing of due many growth factors contains. The aim this study investigate therapeutic effectiveness assess surgical repair after RLN injury. Materials Methods...

ABSTRACT Sepsis-induced acute liver injury is a life-threatening condition involving inflammation, oxidative stress, and endothelial dysfunction. In the present study, preventive effects of resveratrol (RV) alone resveratrol-loaded silver nanoparticles (AgNPs+RV) against sepsis-induced damage were investigated compared in rat model polymicrobial sepsis induced by cecal ligation puncture (CLP). Rats divided into four groups: Sham, CLP, RV, AgNPs+RV. Pro-inflammatory cytokines (tumor necrosis...

Objectives: Interactions between neuropeptides and psychiatric disorders have been investigated for many years. The aim of this study was to evaluate oxytocin (OXT), arginine-vasopressin (AVP), atrial natriuretic peptide (ANP) assess their interactions with each other, as well investigate these changes the manifestations schizophrenia. Participants methods: Thirty-four individuals having acute schizophrenia 24 healthy control group were included in study. Positive Negative Syndrome Scales,...

Coronavirus disease 2019 (COVID-19) patients are predisposed to thrombotic events. COVID-19 coagulopathy can be associated with ADAMTS-13 (a disintegrin-like and metalloprotease thrombospondin type I repeats 13) levels. ADAMTS-13, the cleaving protease of highly thrombogenic ultra-large von Willebrand Factor (vWF) multimers, was rarely investigated in inconsistent results were obtained. We measured levels admitted emergency department.

This study aimed to determine anti-inflammatory, antioxidant, and antiapoptotic properties of urapidil (Ura) against ovarian torsion detorsion (T/D) injury in rats.40 female Wistar albino rats were grouped as sham, T/D, T/D+dimethyl sulfoxide (DMSO), T/D+Urapidil 0.5 mg/kg (low dose), 5 (high dose) groups. In treatment groups, Ura was administered intraperitoneally just before detorsion. Biochemical parameters (TAS, TOS, MDA, MPO, SOD) immunohistochemical (IL-1β, TNF-α, NF-κB, LC3B,...

Sepsis causes life-threatening tissue and organ dysfunctions caused by endogenous mediators in response to infection. Melatonin is a powerful anti-inflammatory agent effective reducing cellular damage. This study aimed evaluate the changes serum liver levels of VEGF, TGF-β MMP-2 melatonin-treated septic rats.Twenty-one Wistar-albino male rats were included this study. Rats randomly divided into three groups. Group 1 sham-operated control (C) group, 2 caecal ligation puncture (CLP) group 3...

Ovarian ischemia-reperfusion (I-R) injury may damage remote organs, including the lungs. We investigated whether apocynin, a NADPH oxidase inhibitor, might protect against ovarian I-R induced apoptosis in lungs of rats. Bilateral was for 3 h, then apocynin applied at two concentrations. Lung tissue evaluated using spectrophotometric and immunohistochemical methods. found that increased total oxidant status (TOS), oxidative stress index (OSI) myeloperoxidase (MPO) levels, immunostaining...

ÖZET Amaç: El hijyeni, sağlık bakımıyla ilişkili enfeksiyonların (SBİE) önlenmesinde en etkili, kolay ve ucuz yöntemdir. Bu çalışmada amaç; Sağlık Hizmetleri Meslek Yüksekokulu’nda (SHMYO) öğrenim gören üniversite öğrencilerine verilen el hijyeni eğitiminin etkinliğini değerlendirmektir. Yöntem: Çalışma, gerekli izinler sonrasında, Nisan 2017’de Sakarya Üniversitesi SHMYO’da yapıldı. Eğitimler, enfeksiyon kontrol hemşiresi tarafından verildi. Eğitim öncesi (EÖ) eğitim sonrası (ES)...

Premature ovarian insufficiency (POI) contributes significantly to female infertility. Cyclophosphamide (CYC has adverse effects on folliculogenesis. Platelet-rich plasma (PRP) is an autologous product rich in many growth factors. We evaluated the protective effect of PRP vitro fertilization rats with CYC-induced damage. Twenty-eight adult Sprague-Dawley were randomly divided into four groups. Group 1 (control-sodium chloride 0.9%; mL/kg, single-dose intraperitoneal [IP] injection); group 2...

<title>Abstract</title> <bold>Aim:</bold>Chronic stress plays an important role in the pathophysiology of depression. In this study, we aimed to investigate therapeutic effects Bactolac (<italic>Lactobacillus plantarum NBIMCC 8767+Streptococcus thermophilus 8258</italic>) on chronic stress-induced depression rats. <bold>Methods:</bold>This study was performed a total 28 rats, control (C), (S), (B), Bactolac+stress (BS) groups (each n=7). Behavioral tests were evaluate depressive behaviors...

Recurrent Laryngeal Nerve (RLN) injury is a complication in neck surgery. The aim of this study to evaluate the effect primary suture repair with melatonin treatment on nerve regeneration after RLN damage. After damage, was performed first and fourth groups. third groups were given intraperitoneal therapy daily for six weeks. EMG applied all subjects vocal cord movements evaluated endoscopically. At end sixth week, sacrificed, their larynx examinedhistologically. Vocal paralysis (VCP)...

This study aimed to investigate the effects of ketogenic diet (KD), intermittent fasting (IF), and their combination on testicular tissue hormonal changes in adult male rats. Twenty-eight rats were randomly divided into four groups: control (CD), KD, IF, KD combined with IF (IF + KD). Body weights recorded, serum estradiol testosterone levels analyzed, oxidative stress parameters nitric oxide (NO) assessed. Furthermore, histopathological analysis was conducted. notably enhanced body testis...

Objective: This study investigated changes in serum oxidative stress parameters burn cases compared to healthy controls. Materials and Methods:This was performed 41 patients with mild severe thermal injuries 38 volunteers.The were selected from who hospitalized the unit for treatment of second-and third-degree burns.Malondialdehyde (MDA) levels PON-1 paraoxonase arylesterase activities measured patient samples.Results: activity MDA major injury significantly higher than controls, but lower.A...

Tear fluid has a critical role for the function of refraction index light and quality image.The purpose this study is to compare tear ocular dominance in patients with refractive errors.One hundred three mean age 35.63±14.95who was referred ophthalmology service examination were enrolled study.The handedness determined by Edinburgh hand preference questionnaire other tests.Visual acuity tested ophthalmological methods Schirmer test administered patients.Our included seventy-three female...

AMAÇ: Bu çalışmada Streptozotosin (STZ) ile deneysel tip 1 diyabet oluşturulan sıçanların kan ve karaciğer dokularında oluşan oksidatif hasara karşı melatonin takviyesinin koruyucu etkisinin araştırılması amaçlandı. GEREÇ YÖNTEM: Kırk adet yetişkin Spraque Dawley erkek sıçan; grup 1- kontrol grubu, 2-diyabet grup, 3- takviye grubu 4- olmak üzere dört gruba ayrıldı. Sıçanlara tek doz 60 mg/kg STZ İntraperitoneal (i.p.) olarak uygulanması oluşturuldu. Melatonin takviyesi ise 10 mg/kg/gün...

Objective: In this study, it was aimed to research the effects of nutrition with different diets on telomere length granulosa cells.&#x0D; Material and Methods: 21 BALB C female rats (in each group; n = 7) were divided into three groups as standard diet group (SD), ketogenic (KD) western group. The animals in SD fed mouse feed, while KD WD specially prepared diets. At end experiment, a controlled superovulation stimulation protocol applied both ovaries. Smear preparations ready for (GLT)...

The aim of this study is to determine the antioxidant and anti-infl ammatory eff ects Nicotinamide Adenine Dinucleotide (NAD + ) in preventing multi-organ damage caused by sepsis.Twenty-eight male Wistar-albino rats were randomly divided into four groups.The groups comprised Sham group, sepsis group (CLP), 100 mg/kg NAD (CLP+N100) 300 (CLP+N300).Sepsis was induced cecum ligation perforation (CLP) method.NAD administered intraperitoneally for five days before 6 h after operation.Serum, liver...

ÖZ Amaç: Kontrollü overyan hiper stimülasyon (KOH), in vitro fertilizasyon (IVF) tedavilerinin temeli durumundadır. Folükül stimüle edici hormon (FSH), antral folliküllerin büyümesinin temel düzenleyicisi iken, lüteinleştirici (LH) da steroidogenezin desteklenmesinde etkindir. LH stimülasyonda etkili olmasına rağmen, literatürde KOH’ a takviyesi eklenmesi hakkında net bir görüş birliği bulunmamaktadır. Bizde çalışmamızda kendi kliniğimizdeki olgularda;İn fertilizasyon/intrasitoplazmik sperm...

Smoking is an increasingly important public health problem because of the problems it causes.We aimed to investigate whether there a relationship between nicotine addiction level, education type and gender in vocational school services students who smoke study.This descriptive study was conducted with first second year university studying various associate degree programs field.In study, questionnaire forms were used determine sociodemographic conditions prepared scientific support as data...