A5014089174- Urinary Bladder and Prostate Research
- Tryptophan and brain disorders
- Sexual function and dysfunction studies
- Hormonal and reproductive studies
- Pelvic floor disorders treatments
- Alzheimer's disease research and treatments
- Stress Responses and Cortisol
- Natural Antidiabetic Agents Studies
- Hormonal Regulation and Hypertension
- Diet and metabolism studies
- Neurotransmitter Receptor Influence on Behavior
- Adipokines, Inflammation, and Metabolic Diseases
- Urinary Tract Infections Management
- Diabetes Treatment and Management
- Biochemical effects in animals
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Nigella sativa pharmacological applications
- Medicinal plant effects and applications
- Atherosclerosis and Cardiovascular Diseases
- Nicotinic Acetylcholine Receptors Study
- Cancer-related cognitive impairment studies
- Pharmacological Effects and Toxicity Studies
- Attention Deficit Hyperactivity Disorder
- Cholinesterase and Neurodegenerative Diseases
- Obsessive-Compulsive Spectrum Disorders
Sağlık Bilimleri Üniversitesi
2025
University of Health Sciences Antigua
2024
University of Health Sciences
2024
Marmara University
2016-2023
Sakarya University
2016-2022
Abstract Chronic stress is linked to changes in brain physiology and functioning, affects the central nervous system (CNS), causes psychiatric diseases such as depression anxiety. In this study, antidepressant effects of probiotic bacterium Lactobacillus rhamnosus GG (ATCC 53103) (LGG) (15 × 10 8 cfu/ml/day) on mechanisms playing a role pathophysiology were investigated, results compared with bupropion (20 mg/kg/day) venlafaxine mg/kg/day). A total 56 male Wistar Albino rats used control,...
Nephrolithiasis is common urological problem and stone formation has multiple underlying pathogenetic factors.We investigated the possible preventive therapeutic effects of Urtica dioica ethanol extract (UD) on ethylene glycol-induced nephrolithiasis model in rats.Sprague-Dawley rats were divided into four groups (n = 10).The control group was given normal drinking water for 8 weeks administered vehicle by gastric gavage.Stone induced adding 0.75% glycol (EG) to their water.UD (700 mg/kg)...
Alzheimer's disease (AD) and Type 2 Diabetes Mellitus (T2DM) are both characterized by similar pathologies, studies have shown that various drugs from groups may be effective in another.The effects of sodium-glucose co-transporter (SGLT)2 inhibitors AD unknown.According to molecular docking studies, SGLT acetylcholinesterase (AChE) inhibition activity, which is therapeutic target for AD.In this study, we investigated the SGLT2 inhibitor dapagliflozin on intracerebroventricular (icv)...
Mirabegron is the first b3-adrenoceptor agonist to enter clinical practice and has been approved for treatment of symptoms OAB. The aim this study investigate whether mirabegron an effect on depression, anxiety, learning, memory. We investigated effects learning memory by using forced swimming test, elevated plus maze passive avoidance Morris water in mice. Imipramine (3, 6 9 mg/kg) significantly reduced immobility time test. Diazepam increased spent open arms number entries Furthermore,...
<title>Abstract</title> <bold>Aim:</bold>Chronic stress plays an important role in the pathophysiology of depression. In this study, we aimed to investigate therapeutic effects Bactolac (<italic>Lactobacillus plantarum NBIMCC 8767+Streptococcus thermophilus 8258</italic>) on chronic stress-induced depression rats. <bold>Methods:</bold>This study was performed a total 28 rats, control (C), (S), (B), Bactolac+stress (BS) groups (each n=7). Behavioral tests were evaluate depressive behaviors...
Objective: The aim of this study was to reveal the effect apocynin (APO) on factors involved in obesity-related endothelial dysfunction (ED) and atherosclerosis (AS). Materials Methods: Male Wistar albino rats were divided into control (CNT), high-fat diet (HFD) HFD+APO groups. HFD groups fed for sixteen weeks. APO (25 mg/kg) administered group last four effects on: AS-related metabolic parameters (triglyceride, total cholesterol, high-density lipoprotein-cholesterol, insulin leptin),...
Çoklu ilaç tedavileri kaçınılmaz olarak ilaç-ilaç etkileşmelerine neden olabilmektedir. Bu durum ciddi sağlık sorunlarına yol açmakta ve hastaların zarar görmesi durumunda malpraktis açısından da hekimleri sorumlu hale getirmektedir. tedavisi rejimleri her zaman için olumsuz etkileşme riskini taşırlar. hem bunaltmakta de riski taşımaları nedeniyle, bu tedavi rejimlerinin güvenliliğini sorgulanır yazıda, etkileşmeleri hakkında genel bilgiler yanında önemli örnekleri verilecektir. Yine...
Objective: Overactive bladder (OAB) constitutes the majority of childhood incontinence causes. Oxybutynin is an antimuscarinic agent frequently used for children in treatment OAB. This study aimed to investigate effects drug oxybutynin on learning and memory. Materials Methods: We assessed memory functions using Passive Avoidance (PA) Morris Water Maze (MWM) Test mice. Results: (1 mg/kg, 2 4 mg/kg) did not show a significant difference retention time second day compared control (4...
Objective: Erectile dysfunction is a usual side effect of antipsychotic medications; this causes patients to avoid using drugs. The aim study investigate the effects iloperidone, paliperidone and loxapine on serotonin (5-HT), noradrenaline (NA), adenosine triphosphate (ATP) potassium chloride (KCl)-induced contractions vas deferens in mice.Materials Methods: mice were randomly divided into experimental groups treated by ip injection drugs for 21 days. After treatment, investigated 5-HT, ATP,...
Objective: Ziprasidone, aripiprazole, blonanserin, cyamemazine, and nemonapride are atypical antipsychotic drugs used for the treatment of schizophrenia. This study aimed to identify effects these in mice isolated bladder using organ bath systemMaterials Methods: The were injected intraperitoneally with 21 days. investigated on isoproterenol-induced relaxation responses carbachol-induced contractions detrusor strips. strips stimulated KCl, then tissues washed a further 30 min precontracted...
Objective: The purpose of this study was to examine the protective effects Myrtus communis L. (MC) extract on high fat-diet (HFD) induced heart and aorta damage by evaluating oxidative stress endothelial nitric oxide system (eNOS). Materials Methods: Wistar albino male rats were divided into 3 groups (n=7) as control, HFD, HFD+MC. Rats in HFD HFD+MC fed for 16 weeks last 4 saline or MC (100 mg/kg) administered orally (5 days/week). Triglyceride, cholesterol, high-density lipoprotein (HDL)...
Objective: The bladder normally shows no contractility or activity during the filling phase. In overactive urinary bladder, spontaneous contractions and detrusor instability are seen in phase incontinence occurs. This study aims to demonstrate effects of first-generation antipsychotic haloperidol second-generation antipsychotics olanzapine, risperidone, clozapine on mice isolated using organ bath system. Materials Methods: 63 male inbred were divided as saline, 0.125 mg/kg, 0.25 olanzapine 1...
Aims: Antipsychotic drugs are known to be commonly associated with sexual dysfunction. The aim of this study investigate the effects sertindole, asenapine and ziprasidone on serotonin (5-HT), noradrenaline (NA), adenosine triphosphate (ATP) potassium chloride (KCl)-induced contractions isolated vas deferens in mice.
 Study design: All were administered intraperitoneally (i.p.) a volume 0.1 ml per 10 g body weight Place Duration Study: Department Pharmacology, Kocaeli University, Animal...