A5074999505- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Thermal Regulation in Medicine
- Zebrafish Biomedical Research Applications
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Blood properties and coagulation
- Reproductive System and Pregnancy
- Nanoparticles: synthesis and applications
- Complement system in diseases
- Hemoglobin structure and function
- Aquaculture disease management and microbiota
- Nicotinic Acetylcholine Receptors Study
- Immune responses and vaccinations
- Monoclonal and Polyclonal Antibodies Research
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- vaccines and immunoinformatics approaches
- Tuberculosis Research and Epidemiology
- Graphene and Nanomaterials Applications
- Nanoparticle-Based Drug Delivery
Universidade de Vigo
2012-2025
Instituto de Investigación Sanitaria de Santiago
2020
Galicia Sur Biomedical Foundation
2018
The recognized necessity for new antigen delivery carriers with the capacity to boost, modulate and prolong neutralizing immune responses prompted our approach, in which we describe a multifunctional nanocarrier consisting of an oily nanocontainer protected by polymeric shell made chitosan (CS), named CS nanocapsules (CSNC). can associate on its surface, whereas core might provide additional immunostimulating properties. In this first characterization system, intended study influence...
The use of biomaterials and nanosystems in antigen delivery has played a major role the development novel vaccine formulations last few decades. In an effort to gain deeper understanding interactions between these systems immunocompetent cells, we describe here systematic vitro vivo study on three types polymeric nanocapsules (NCs). These carriers, which contained Protamine (PR), Polyarginine (PARG) or Chitosan (CS) external shell, their corresponding nanoemulsion were prepared main...
ABSTRACT Background The global pandemic caused by SARS‐CoV‐2 has resulted in millions of people experiencing long COVID condition, a range persistent symptoms following the acute phase, with an estimated prevalence 27%–64%. Materials and Methods To understand its pathophysiology, we conducted longitudinal study on viral load cytokine dynamics individuals confirmed infection. We used reverse transcriptase droplet digital PCR to quantify RNA from nasopharyngeal swabs employed multiplex...
Multiple sclerosis (MS) involves immune dysregulation and abnormal ion channel function. This study investigated the expression function of voltage-gated potassium (Kv) isoforms (Kv1.1, Kv1.2, Kv1.3, Kv1.6, Kv4.2, Kv4.3, Kv7.2) in peripheral blood mononuclear cells (PBMCs) lymphocytes from MS patients (remittent-recurrent) compared to controls. We found an upregulation six out seven Kv PBMCs patients, with sex-specific differences observed (female showing a more pronounced specific...
The common octopus, Octopus vulgaris Cuvier 1797, as all cephalopods, presents highly evolved characteristics compared to other classes of molluscs and the whole invertebrate phyla. However, date, there is not much information about its immune system, studying defense mechanisms a key step in understanding their response external aggressions, having tools anticipate animal health problems ensure welfare. lack cell cultures major problem when carrying out vitro assays that help deepen our...
ObjectivesTo identify new potential host biomarkers in blood to discriminate between active TB patients, uninfected (NoTBI) and latently infected contacts (LTBI).MethodsA cell count was performed study parent leukocyte populations. Peripheral mononuclear cells (PBMCs) were isolated a multi-parameter flow cytometry assay conducted the distribution of basal Mycobacterium tuberculosis (Mtb)-stimulated lymphocytes. Differences groups area under ROC curve (AUC) investigated assess diagnostic...
To develop a new core-shell type (nanocapsules) adjuvant system composed of squalene and polyglucosamine (PG) to evaluate its immunostimulant capacity.The defined PG nanocapsules exhibited the capacity efficiently associate selected antigens (recombinant hepatitis B surface antigen hemagglutinin influenza virus) onto their polymeric (70-75%), imiquimod within oily core. The resulting nanovaccines, with particle size 200-250 nm positive zeta-potential (∼+60 mV), were able significantly...
One of the main challenges in development vaccine has been to improve their stability at room temperature and eliminate limitations associated with cold chain storage. In this paper, we describe optimization thermostable nanocarriers consisting an oily core immunostimulating activity, containing squalene or α tocopherol surrounded by a protamine shell. The results showed that these nanocapsules can efficiently associate recombinant hepatitis B surface antigen (rHBsAg) without compromising...