Inflammatory dilated cardiomyopathy (DCMi) is a major cause of heart failure in individuals below the age 40. We recently reported that IL-17A required for development DCMi. show novel pathway connecting IL-17A, cardiac fibroblasts (CFs), GM-CSF, and heart-infiltrating myeloid cells with pathogenesis Il17ra−/− mice were protected from DCMi, this was associated significantly diminished neutrophil Ly6Chi monocyte/macrophage (MO/MΦ) infiltrates. Depletion MO/MΦ also Mechanistically, stimulated...

Physician migration, also known as "brain drain," results from a combination of gap in the supply and demand developed countries lack job satisfaction developing countries. Many push pull factors are responsible for this effect, with media internet playing their parts. Large-scale physician migration can pose problems both donor recipient countries, resulting reinforcement economic divide between The main objectives our study were to determine prevalence intentions medical undergraduates,...

Periodontal and peri-implant diseases are a significant public health problem worldwide, resulting in the destruction of supporting bone. These bone defects can cause esthetic problems, increased relapse rate, eventually tooth loss. The etiology periodontal disease involves an influx innate immune cells (neutrophils monocytes) upregulation local inflammatory cytokines gingiva. Biodegradable polymeric nanoparticles inexpensive, safe, effective means preventing activation by bacterial...

The current study was aimed to assess the relationship between gratitude, life satisfaction and psychological well-being among hospitalised individuals find out difference of Satisfaction, gratitude in relation demographic variables (gender, marital status). Sample 250 students from hospitals AJ&K taken. Gratitude Scale, Satisfaction with Life Scale (SWLS) Psychological Well-being (PMWBS) were used. Total 25 items questionnaires given participants three (AIMS Muzaffarabad, CMH Rawalakot...

The Expanded Program on Immunization (EPI) was initiated by World Health Organization (WHO) in 1974 order to save children from life threatening, disabling vaccine-preventable diseases (VPDs). In Pakistan, this program launched 1978 with the main objectives of eradicating polio 2012, eliminating measles and neonatal tetanus 2015, minimizing incidence other VPDs. However, despite efforts government WHO, has not received amount success that desired. Hence, study were elucidate reasons behind...

Current gold standard therapeutic strategies for T2DM target insulin resistance or β cell dysfunction as their core mechanisms of action. However, the use traditional anti-diabetic drugs, in most cases, does not significantly reduce macrovascular morbidity and mortality. Among emerging candidates, glucagon like peptide-1 (GLP-1) based therapies carry special cardiovascular implications, exerting both direct well indirect effects. The effects GLP-1 its analogs remain focus this review.

Akt, better known as protein kinase B (PKB), is a serine/threonine-specific which acts mediator via PI3K/Akt pathway in many biological processes like glucose metabolism, apoptosis, cell differentiation and transcription. Akt1 gene amplification has been implicated gastric carcinoma while Akt2 linked with ovarian, pancreas, breast stomach tumors. The use of Akt inhibitors monotherapy or combination other anticancer drugs could be useful for combating drug resistance improving response. Thus,...

Birth defects are defined as those conditions that substantially determined before or during birth and which recognizable in early life. They an important cause of morbidity mortality infants. The main objective the study was to determine association certain risk factors with occurring pediatric patients seeking care Civil Hospital, Karachi. This a prospective, cross-sectional conducted at Department Pediatrics: Units I, II III Hospital Karachi, is tertiary hospital located city center....

Abstract c-Met is a receptor tyrosine kinase that encodes protein such as hepatocyte growth factor (HGFR). Inappropriate activity of can cause wide variety carcinomas. inhibitor are relatively new class small molecules inhibit the enzymatic kinase. Met inhibitors divided into two main classes: I (SU-11274-like) and II (AM7-like). The use with other therapeutic agents could be crucial for overcoming potential resistance well improving overall clinical benefit. pathway might used in...

The Wnt proteins are a family of 19 secreted glycoproteins that occupy crucial roles in the regulation processes such as cell survival, proliferation, migration and polarity, fate specification, body axis patterning self-renewal stem cells. canonical pathway has been implicated variety cancers. As such, it is only fair to conclude therapies targeting may play an essential role future anticancer therapeutics, both alone or conjunction with traditional therapies.

The Hedgehog (Hh) proteins comprise a group of secreted that regulate cell growth, differentiation and survival. Inappropriate activation the Hh signaling pathway has been implicated in development variety cancers. inhibitors are relatively new class therapeutic agents act by targeting involved regulation (PTCH, SMO Gli). Together, they serve as exciting prospects, with bright future, both alone or an adjuvant to more traditional anti-cancer drugs.

The duty of a doctor to take care presumes the person who offers medical advice and treatment unequivocally possess skills knowledge do so. However, sense responsibility cannot be guaranteed in absence accountability, which turn requires comprehensive law system place. Such is almost non-existent Pakistan. Keeping above mind, we designed this study assess knowledge, attitudes practices surgeons regarding malpractice at tertiary center Pakistan.This was an observational, cross-sectional,...

The objective of this study is to determine the time interval from decision seek medical help and arrival patients emergency department (ED).The duration stay in ED was also calculated.This assesses factors responsible delayed presentation hospital.This prospective conducted during day timings (9 am 3 pm) May 2012 August at Civil Hospital, Karachi.Patients older than 18 years meeting inclusion criteria were considered be eligible for study.Statistical analysis done using SPSS version 17.The...

Poly(ADP-ribose) polymerases (PARPs) comprise of a large family 17 proteins encoded by various genes which participate in genome maintenance, apoptosis, inflammatory responses and the regulation gene expression programs. PARP inhibitors, as therapeutic agents, come into play acting on both 1 2. These drugs seem to target tumor cells moment vulnerability when they are undergoing DNA repair. In past few years this class anti-cancer drug has been discovered show promising niche clinic.

Although cricket has origins in the British Empire, it is followed as a religion South Asia, probably due to influence of former during their rule.The sport equally popular among all groups society, and not subject gender or age constraints.It marks epitome reverence considered battle for self-esteem, only those playing, but watching well.The intensity emotional attachment with this renders certain public health benefits well drawbacks general masses.

This study investigated the perceptions of Muslim religious scholars on media representation terrorism in Kenya. Kenya presents a unique context for because its diverse landscape, specific experiences with and upsurge digital platforms news dissemination. Kenya, therefore, play critical role within communities as they look after their congregation. The phenomenological theory was used framework study. found that there general perception among biased towards population. are view Muslims were...

The motivating premise of this study is to improve the treatment periodontal disease by elucidating sex-specific mechanisms progression. Men and women experience inflammation in fundamentally different ways understanding biology leading bone loss periodontium will inevitably patient outcomes. We therefore examined clinical immunological differences progression using ligature-induced periodontitis model. Periodontitis was induced male female C57BL/6j mice tying a 5-0 silk suture around left...