A5083523838- Hair Growth and Disorders
- Dermatology and Skin Diseases
- Pneumonia and Respiratory Infections
- Bacterial biofilms and quorum sensing
- Antimicrobial Peptides and Activities
- Inhalation and Respiratory Drug Delivery
- Dermatologic Treatments and Research
- Medicine and Dermatology Studies History
- Systemic Sclerosis and Related Diseases
- Medical and Biological Ozone Research
- Gout, Hyperuricemia, Uric Acid
- Biochemical and Structural Characterization
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Advancements in Transdermal Drug Delivery
- Pediatric health and respiratory diseases
- Autoimmune Bullous Skin Diseases
- Suicide and Self-Harm Studies
- Radiomics and Machine Learning in Medical Imaging
- Linguistic research and analysis
- Linguistics, Language Diversity, and Identity
- Lexicography and Language Studies
- RNA Interference and Gene Delivery
- Musculoskeletal synovial abnormalities and treatments
- Bone and Joint Diseases
- Advanced Drug Delivery Systems
Helmholtz Institute for Pharmaceutical Research Saarland
2019-2021
Helmholtz Centre for Infection Research
2019-2021
Saarland University
2018-2021
Abstract Pseudomonas aeruginosa (PA) infections can be notoriously difficult to treat and are often accompanied by the development of antimicrobial resistance (AMR). Quorum sensing inhibitors (QSI) acting on PqsR (MvfR) – a crucial transcriptional regulator serving major functions in PA virulence enhance antibiotic efficacy eventually prevent AMR. An integrated drug discovery campaign including design, medicinal chemistry‐driven hit‐to‐lead optimization in‐depth biological profiling new QSI...
Abstract Elimination of pulmonary Pseudomonas aeruginosa (PA) infections is challenging to accomplish with antibiotic therapies, mainly due resistance mechanisms. Quorum sensing inhibitors (QSIs) interfering biofilm formation can thus complement antibiotics. For simultaneous and improved delivery both active agents the infection sites, self‐assembling nanoparticles a newly synthesized squalenyl hydrogen sulfate (SqNPs) were prepared. These nanocarriers allowed for remarkably high loading...
Tofacitinib (TFB), a Janus kinase inhibitor, has shown excellent success off-label in treating various dermatological diseases, especially alopecia areata (AA). However, TFB's safe and targeted delivery into hair follicles (HFs) is highly desirable due to its systemic adverse effects. Nanoparticles (NPs) can enhance follicular drug minimize interfollicular permeation thereby reduce exposure. In this study, we report facile method assemble the stable uniform 240 nm TFB loaded squalenyl...
Limited drug loading capacity (LC), mostly below 5% w/w, is a significant drawback of nanoparticulate delivery systems (DDS). Squalenoylation technology, which employs bioconjugation squalenyl moiety and drug, allows self-assemble nanoparticles (NPs) in aqueous media with significantly high LC (>30% w/w). The synthesis particle preparation squalenoylated prodrugs are, however, not facile for molecules multiple reactive groups. Taking different approach, we describe the amphiphilic...
Since February 2002, a first version of the Deutsche Wörterbuch (DWB) by Jacob and Wilhelm Grimm has been available on web. A CD‐ROM beta since December 2002. This paper will focus steps involved in drawing up an electronic DWB and, demonstrating design Graphical User Interface (GUI), show how common standards digitization were taken into account user needs anticipated during production process. The history structure be outlined to point out some characteristics dictionary. process...
Abstract Elimination of pulmonary Pseudomonas aeruginosa (PA) infections is challenging to accomplish with antibiotic therapies, mainly due resistance mechanisms. Quorum sensing inhibitors (QSIs) interfering biofilm formation can thus complement antibiotics. For simultaneous and improved delivery both active agents the infection sites, self‐assembling nanoparticles a newly synthesized squalenyl hydrogen sulfate (SqNPs) were prepared. These nanocarriers allowed for remarkably high loading...
Der simultane Transport von Tobramycin- und Alkylchinolon-Inhibitoren durch ein selbstorganisiertes Nanopartikelsystem basierend auf Squalenylhydrogensulfat (SqNPs) stellt eine optimale therapeutische Maßnahme gegen Biofilminfektionen mit P. aeruginosa dar. Wie C.-M. Lehr et al. in ihrer Zuschrift S. 10378 beschreiben, zeigt das wirkstoffbeladene SqNPs verbesserte Biofilmpenetration verstärkte Wirksamkeit relevanten biologischen Barrieren, was zu einer vollständigen Eradikation...
In article number 2004369, Martin Empting and colleagues describe a new generation of dual-loaded nanoparticles enabling efficient eradication Pseudomonas aeruginosa biofilms. The squalene-based nanocarrier facilitates co-delivery novel pathogenspecific Quorum Sensing Inhibitor (QSI) together with the standard-of-care antibiotic tobramycin. QSI itself shows high anti-virulence efficacy, favorable DMPK no overt safety pharmacology. When applied as nanoparticle formulation potentiates biofilm...