A5041507289- Dermatology and Skin Diseases
- Asthma and respiratory diseases
- Animal Behavior and Welfare Studies
- Neuroendocrine regulation and behavior
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Ion Channels and Receptors
- Animal testing and alternatives
- Stress Responses and Cortisol
- Mast cells and histamine
- Contact Dermatitis and Allergies
- Pain Management and Treatment
- Vagus Nerve Stimulation Research
- Circadian rhythm and melatonin
- Zebrafish Biomedical Research Applications
- Transcranial Magnetic Stimulation Studies
- Hair Growth and Disorders
- Cephalopods and Marine Biology
- Human-Animal Interaction Studies
- Behavioral Health and Interventions
- Aquaculture disease management and microbiota
- IL-33, ST2, and ILC Pathways
- Autoimmune Bullous Skin Diseases
- Insect and Pesticide Research
- Rabbits: Nutrition, Reproduction, Health
Federal Institute for Risk Assessment
2022-2025
Freie Universität Berlin
2020-2024
Institute of Pharmacology
2022
University of Veterinary Medicine Hannover, Foundation
2021
North Carolina State University
2018-2021
Two histamine receptor subtypes (HR), namely H1R and H4R, are involved in the transmission of histamine-induced itch as key components. Although exact downstream signaling mechanisms still elusive, transient potential (TRP) ion channels play important roles sensation histaminergic non-histaminergic itch. The aim this study was to investigate involvement TRPV1 TRPA1 inhibitors modulate H1R- H4R-induced signal tested a scratching assay mice vivo well via Ca
Tofacitinib (TFB), a Janus kinase inhibitor, has shown excellent success off-label in treating various dermatological diseases, especially alopecia areata (AA). However, TFB's safe and targeted delivery into hair follicles (HFs) is highly desirable due to its systemic adverse effects. Nanoparticles (NPs) can enhance follicular drug minimize interfollicular permeation thereby reduce exposure. In this study, we report facile method assemble the stable uniform 240 nm TFB loaded squalenyl...
Topical administration of PR022, 0.05% hypochlorous acid (HOCl) in gel has been demonstrated to be beneficial a chronic murine atopic dermatitis model. In follow up study we tested higher concentration (0.1%) PR022 HOCl comparison the Janus kinase inhibitor tofacitinib, both which are currently clinical phase studies for treatment human dermatitis. The effect topically administered was compared topical formulation tofacitinib (0.5%) therapeutic setting on dermatitis-like lesions NC/Nga mice...
BackgroundLympho-epithelial Kazal-type-related inhibitor (LEKTI) is a serine protease consisting of multiple domains. A loss function mutation described in Netherton patients that show severe symptoms atopic lesions and itch.ObjectivesLEKTI domain 6 (LD6) has shown strong protease-inhibitory action vitro assays thus it was tested vivo for potential anti-inflammatory models skin disease.MethodsHuman equivalents were treated with LD6 an inflammatory reaction challenged by kallikrein-related...
Non-aversive handling and training techniques for laboratory animals are required to facilitate experimental routine husbandry procedures, improving both animal welfare scientific quality. Clicker was utilized develop protocols rabbits refine stressful procedures usually associated with lifting (i.e., being picked up from the floor)/restraining held in arms of a human) them. Thirteen female New Zealand White were trained over three weeks. All learned predefined goal behaviors: they followed...
Fast and effective anesthesia is the key for refining many invasive procedures in fish gaining reliable data. For as all vertebrates, it also required by European law to reduce pain, suffering, distress unavoidable minimum husbandry experiments. The most often used substance induce zebrafish tricaine (MS-222). When properly prepared dosed, causes rapid loss of mobility, balance reaction touch. These signs are interpreted a stage deep although its effects on central nervous system have not...
Abstract The development of atopic dermatitis (AD) in infancy, and subsequent allergic rhinitis, food allergies, asthma later childhood, is known as the march. mechanism largely unknown, yet course disease indicates contribution inter-epithelial crosstalk, through to onset inflammation skin progression another mucosal epithelium. Here, we investigated if how skin-lung epithelial crosstalk could contribute First, emulated this indirect co-culture bioengineered atopic-like models...
Background: Lympho-epithelial Kazal-type-related inhibitor (LEKTI) is a serine protease consisting of multiple domains. A loss function mutation described in Netherton patients that show severe symptoms atopic lesions and itch. Objectives: LEKTI domain 6 (LD6) has shown strong protease-inhibitory action vitro assays thus it was tested vivo for potential anti-inflammatory models skin disease. Methods: Human equivalents were treated with LD6 an inflammatory reaction challenged by...