Background/Objectives: The discovery of new molecules to which bacteria have not yet developed resistance is a significant medical priority. Synthetic flavonoids are good candidates for developing antimicrobials. Our study investigates series newly synthesized tricyclic with several different substituents on the flavonoid core. Methods: By varying nature rings A and B, structure–activity relationship using microbial strains has been performed. antibacterial antifungal properties these...

A structure–activity relationship study concerning the antibacterial properties of several halogen-substituted tricyclic sulfur-containing flavonoids has been performed. The compounds have synthesized by cyclocondensation corresponding 3-dithiocarbamic flavanones under acidic conditions. influence different halogen substituents on tested against Staphylococcus aureus and Escherichia coli . Amongst N , -dialkylamino-substituted flavonoids, those having an -diethylamino moiety exhibited good...

An addition/elimination sequence of selenium halides to pseudo-geminally bis(acetylene) substituted [2.2]paracyclophanes leads new bridges with an endo - exo -diene substructure. The reactions have been found be sensitive the substitution ethynyl group. formation dienes a zig-zag configuration is related that observed for non-conjugated cyclic diynes medium ring size.

The antioxidant properties of 3-dithiocarbamic flavanones have been investigated. influence the halogen substituents on ring A and nature secondary amine from dithiocarbamic moiety accounted. results indicated that presence a substituent at C-8 position benzopyran induce better against DPPH ABTS than butylated hydroxytoluene (BHT) ascorbic acid. mentioned appears to higher stability for free radical intermediate C-3 ring. enolate is most likely be involved in activity this flavanone. It...

Abstract Two racemic tetrathiafulvalene‐[2.2]paracyclophane electron donors EDT‐TTF‐[2.2]paracyclophane 1 and (COOMe) 2 ‐TTF‐[2.2]paracyclophane have been synthesized via the phosphite mediated cross coupling strategy. Chiral HPLC allowed optical resolution of ( R P ) S enantiomers for both compounds. Solid‐state structures )‐ rac determined by single crystal X‐ray analysis. Intermolecular π‐π S•••S interactions are disclosed in packing. Single analysis combined with experimental theoretical...

Several new di- and tetracarboxylic [2.2]paracyclophane derivatives were obtained via Suzuki coupling between the appropriately brominated [2.2]paracyclophanes 4-(methoxycarbonyl)phenylboronic acid. The reaction of one these products, namely pp-bis(4-carboxyphenyl)[2.2]paracylophane (12), with zinc nitrate afforded a 2D coordination polymer comprising zinc-carboxylate paddlewheel clusters linked together by cyclophane cores. center is five-coordinated in square-pyramidal geometry, DMF oxygen...

Methicillin-resistant

Mono-, pseudo-gem, and pseudo-para ethynylcyclophanes bis(azides) have been employed as addition partners in CuAAC reactions to design build complex extended molecular scaffolds. The reactivity of the resulting triazoles was investigated under photochemical conditions. A variety newly substituted [2.2]paracyclophanes were identified; deazotization pseudo-gem adducts provided indolophane derivatives. An intramolecular stabilization effect observed case rearrangement from a adduct pseudo-ortho...

Infections caused by Candida are very difficult to treat due increasing antifungal resistance. Recent studies showed that patients with infections resistant fluconazole have few treatment options. Therefore, finding new efficient agents is a matter of medical high priority. The aim this study was explore the potential BrCl-flav-a representative class synthetic flavonoids bromine as halogen substituent at benzopyran core against four clinical strains. Determination minimum inhibitory...

The synthesis of [2.2]paracyclophane derivatives containing tetrathiafulvalene units has been accomplished by the coupling reaction 4-([2.2]paracyclophan-4-yl)-1,3-dithiol-2-thione in presence trimethylphosphite. 1,3-dithiol-2-thione derivative was turn synthesized regioselective bromination 4-acetyl[2.2]paracyclophane, then through corresponding dithiocarbamates and 1,3-dithiolium salts.

ESKAPE pathogens are considered as global threats to human health. The discovery of new molecules for which these have not yet developed resistance is a high medical priority. Synthetic flavonoids good candidates developing antimicrobials. Therefore, we report here the potent in vitro antibacterial activity BrCl-flav, representative class synthetic tricyclic flavonoids. Minimum inhibitory/bactericidal concentration, time kill and biofilm formation assays were employed evaluate potential...

Mesitylene was used as a core in seven new tritopic nitrogen containing linkers. Three of the linkers, each three nitrile groups, were obtained through Suzuki, Sonogashira and Heck-type coupling reactions. Next, these converted to tetrazol-5-yl moieties by cycloaddition sodium azide functionalities. The last linker, 1,2,3-triazol-4-yl moieties, synthesized Huisgen phenyl corresponding alkyne. latter via Corey-Fuchs reaction sequence from previously reported formyl derivative. As proof...

Background: Due to the emergence of multidrug resistant microorganisms, new classes antibiotics are needed. In this paper, we present cytotoxic effects five tricyclic flavonoids, one which was previously identified as a potent antimicrobial agent. Methods: All derivatives were tested against human HOS and MCF7 cancer cell lines using wound scratch assay. The properties reported flavonoid 4a also evaluated standard MTS...

The conversion of n-heptanes into aromatic hydrocarbons benzene, toluene and xylenes (BTX), by the chromatographic pulse method in temperature range 673 - 823K was performed over HZSM-5 Ag-HZSM-5 zeolites modified ion exchange with AgNO3 aqueous solutions. catalysts, (SiO2/Al2O3 = 33.9), (Ag1-HZSM-5 wt. % Ag1.02, Ag2-HZSM-5 Ag 1.62; Ag3-HZSM-5 2.05 having different acid strength distribution exhibit a yield aromatics depending on metal content. BTX appreciably increased incorporating silver...

Abstract Novel heteroatom containing bridges have been introduced in [2.2]paracyclophanes by the interaction of chalcogenide halides with pseudo-geminal triple bonds. The anti-addition Markovnikov orientation selenium to 4,15-bisethynyl[2.2]paracyclophane leads corresponding E-adducts. pseudo-geminally substituted bispropargylic alcohols disulfur dichloride and sulfur a mixture cyclic ethers. These compounds are formed under mild acidic conditions provided organic ammonium chlorides or...

The rapid emergence and spread of multidrug-resistant microorganisms is threatening our ability to treat common infections, with serious medical, social, economic consequences. Despite substantial progress in the global fight against antibiotic resistance, number effective antibiotics rapidly decreasing, underlying urgent need develop novel antimicrobials. In present study, green synthesis iodine-substituted tricyclic flavonoids has been accomplished using an eco-friendly reagent, HPW-SiO2,...

The antioxidant properties of some 3-dithiocarbamic flavanones were investigated. Based on a previous study, we selected three frameworks that proved to be the most active ones. By varying nature substituent at para-position flavanone ring B, structure–activity relationship study radical scavenging activities was performed. influence these substituents (H, F, Cl, Br and I) evaluated in relation DPPH, ABTS FRAP. results indicated presence halogen induced better than ascorbic acid BHT. found...