Purpose.: The aim of the present study is to evaluate roles TGFs β1 and β2, glial cell line–derived neurotrophic factor (GDNF), nerve growth (NGF) in pathogenesis idiopathic epiretinal membrane (ERM). Methods.: Eight patients, six males two females, with an average age 60.25 ± 17.16 years (range, 33–75 years) who were affected by ERM enrolled study. All patients underwent standard pars plana vitrectomy surgery removal specific ELISA was performed TGFβ1, TGFβ2, GDNF, NGF vitreous samples....

A retrospective chart review of patients with persistent subretinal and/or intraretinal fluid, despite previous treatment intravitreal ranibizumab (0.5 mg), who were switched to aflibercept injections, was performed. Treatment three monthly (2 mg) injections followed by dosing on pro re nata basis. Main outcome measures included changes in best corrected visual acuity (BCVA), 1 mm central subfield (CSF) retinal thickness, the height pigment epithelial detachment (PED), and subfoveal...

Purpose To study macular microvascular changes in ocular Behçet disease (OBD) using optical coherence tomography angiography (OCTA).Methods Quantitative and qualitative analyses of OCTA were performed on 23 OBD patients with active or inactive uveitis compared healthy controls.Results Deep capillary plexus (DCP) is the most frequently involved (p < 0.001). Its vessel density (VD) reduced controls both 0.007) = 0.03). In uveitis, VD inversely related to number relapses (superficial plexus: r...

Purpose: To study use of optical coherence tomography (OCT) for macular edema in uveitis. Methods: In total, 44 patients with uveitis and underwent OCT. Data obtained were correlated anatomic type, duration uveitis, visual acuity (VA). Results: Both cystoid (CME) diffuse (DME) correlate negatively VA, although statistically CME showed stronger correlation (p = .02). Also had higher mean foveal thickness than DME < .01). Negative between VA .05) was observed. correlates Conclusions:...

Purpose: To investigate the incidence and risk factors for main complications in patients with rhegmatogenous retinal detachment treated scleral buckling (SB) or pars plana vitrectomy (PPV). Methods: A retrospective, comparative, observational study was conducted. The medical records of 107 primary who were managed SB (n = 57) PPV 50) reviewed. Scleral performed using encircling solid silicone band circumferential exoplant to support break. Pars combined phacoemulsification phakic eyes...

Purpose: To report clinical features and prognosis of HLA B27 acute anterior uveitis.Methods: 165 patients with recurrent uveitis were divided into two groups: B27-positive (group 1, 60 patients) B27-negative 2, 105 patients). A comparison between the groups was performed.Results: Unilateral involvement higher in group 1 (p = .046), more simultaneous bilateral cases occurred 2 .004). Group correlated to systemic diseases than (50 versus 17.1%, p < .001), particularly ankylosing spondylitis...

To assess the morphological characteristics of uveitic macular edema studied with Spectralis optical coherence tomography (OCT) and to investigate correlation between tomographic features visual acuity.71 eyes 55 patients underwent examination OCT (Heidelberg Engineering, Germany). Data was correlated logMAR best-corrected acuity (BCVA).Two patterns were observed: cystoid (CME) in 69% diffuse 31% eyes. BCVA 0.2 CME, 0.1 (p = 0.008). Foveal thickness 413.4 ± 212 µm 311.27 53 0.03). BVCA 0.3...

Abstract Background Several optical coherence tomography (OCT) biomarkers have been proposed as predictors for functional and anatomical outcomes in Diabetic Macular Edema (DME). This study aims to examine the impact of these OCT features on visual acuity improvement patients with DME after long-acting Dexamethasone intravitreal implants (DEX-I) injection. Furthermore, safety DEX-I clinical parameters, including intraocular pressure (IOP) were assessed. Methods In this retrospective...

Purpose . To investigate the correlation between best-corrected visual acuity (BCVA), foveal inner segment/outer segment (IS/OS) junction or ellipsoid portion of (EPIS/ellipsoid zone), and cone outer tips (COST) line interdigitation zone integrity in eyes with uveitic macular edema (ME). Method A retrospective observational study involving all patients from January 2012 to December 2013 ME was performed. All underwent BCVA using Snellen charts spectral-domain optical coherence tomography...

Purpose. To study epidemiology, clinical findings and visual prognosis of patients with Fuchs' Heterochromic Iridocyclitis (FHI). Methods. A retrospective analysis was performed on 158 FHI. Thirty-five were observed only once; the remaining 123 had a mean follow-up 30.7 months (50 them 63.5 months) in those we assessed complications, medical surgical treatment, long-term prognosis. Results. Average age at uveitis diagnosis 27.2 years 18.3% children. Blurred vision (54.5%) floaters (40.5%)...

Background: Vogt−Koyanagi−Harada (VKH) disease is a form of uveitis that rare in Western countries. The aim this study was to report on the long-term real-life treatment and prognosis VKH Italy. Methods: clinical features, complications, final visual acuity were retrospectively evaluated 38 patients with (mean follow-up: 120 months) globally, according oral or intravenous corticosteroid at onset subsequent immunosuppressive therapy. Results: mean 0.13 ± 0.4 logMAR, which significant increase...

Purpose . To correlate the uveitic epiretinal membrane (ERM) features using spectral-domain optical coherence tomography (SD-OCT) with visual acuity (VA). Methods Forty-one eyes of 32 patients were included in this retrospective study. SD-OCT was performed all and data collected at time ERM diagnosis final visit. Both best corrected (BCVA) thickness correlated morphological clinical features. Results Final BCVA positively male sex focal pattern attachment negatively IS/OS photoreceptor...

&lt;b&gt;&lt;i&gt;Introduction:&lt;/i&gt;&lt;/b&gt; We describe a patient with corneal and scleral dellen, which occurred after an uneventful pterygium excision without adjunctive therapy subsequent febrile episode. &lt;b&gt;&lt;i&gt;Case Report:&lt;/i&gt;&lt;/b&gt; A 43-year-old woman presented history of recurrent irritation in her right eye diagnosis pterygium. The was excised under local anesthesia the bare technique use antimetabolites. No complications until 14 days surgery when sclera...

Background and Objectives: Macular edema (ME) is a common complication of intermediate uveitis (IU). It often responsible for decrease in visual acuity (VA). Three distinct patterns macular have been described uveitis, namely, cystoid (CME), diffuse (DME), serous retinal detachment (SRD). The current study aims to describe the characteristics young patients with idiopathic correlate its features VA using spectral domain optical coherence tomography (SD-OCT). Materials Methods: A total 27...

Importance . Ocular penetrating fish-hook injuries represent an unusual and very dangerous ocular trauma. We report the management of case a simple-single barbed accident globe injury successfully treated with surgery. Observations described caucasian 32-year-old man presented scleral perforation left eye caused by while fishing. The penetrated sclera, passed trabecular meshwork, exited into anterior chamber. He underwent surgery under local anesthesia to remove intraocular foreign body...

purpose. To test the efficacy of intravitreal bevacizumab (IB) in treatment inflammatory choroidal neovascularization (CNV). Methods. A prospective interventional study on patients with subfoveal CNV secondary to posterior/diffuse uveitis treated 1.5 mg/0.05 mL IB. Eight eyes 8 patients, mean follow-up 19.25±6 months, were included. The measurements adopted 1) changes best-corrected visual acuity (BCVA), 2) reduction size, and 3) central foveolar thickness (CFT) measured by optical coherence...

Background: Eales disease is a clinical syndrome affecting the mid-peripheral retina with an idiopathic occlusive vasculitis and possible subsequent retinal neovascularization. The can develop into visually threatening complications. Case Presentation: We report case of 40-year-old Caucasian male history cocaine abuse who presented blurred vision in left eye (LE). Fundus examination showed vitreous hemorrhages, peripheral sheathing venous blood vessels, areas neovascularization LE, phlebitis...

Purpose To report the association between bilateral uveitis with hypopyon and metastatic peritoneal carcinomatosis. Methods A 76-year-old woman presented diffuse hypopyon. She was in good health. reported breast cancer history 20 years before no recurrence of tumor at periodic examinations. Results The patient had visual acuity count fingers both eyes, hypopyon, vitritis chorioretinal lesions. After 1 week steroids, intraocular inflammation improved significantly. Given late age onset,...