A5104636411- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Parasitic Infections and Diagnostics
- Toxoplasma gondii Research Studies
- Herpesvirus Infections and Treatments
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Polyamine Metabolism and Applications
- Chemokine receptors and signaling
- Inflammatory Biomarkers in Disease Prognosis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Histone Deacetylase Inhibitors Research
Eye & ENT Hospital of Fudan University
2022-2025
Fudan University
2024
China Agricultural University
2017-2021
Sun Yat-sen University
2020
The Seventh Affiliated Hospital of Sun Yat-sen University
2020
Immunoscore (IS), based on CD3/CD8, has been proposed to characterize the immune landscape of tumor microenvironment and demonstrated an association with prognosis laryngeal squamous cell carcinoma (LSCC). However, traditional IS does not include immunosuppressive cells. The purpose this study is evaluate prognostic performance cytotoxic-T-lymphocytes cells ratio (CIL) in (LSCC) patients. Two cohorts were included study: training cohort (N = 75) consisted tissue microarrays from LSCC...
Chronic inflammation contributes to tumor initiation, progression, and immune escape. Neutrophils are the major component of inflammatory response participate in tumorigenesis process. However, compared other cells microenvironment laryngeal squamous cell carcinoma (LSCC), neutrophils, especially tumor-associated neutrophils (TANs), have not yet been comprehensively explored. The mechanism for regulating crosstalk between TANs still remains unclear.The distribution profiles phenotypic...
Abstract Tumor‐associated neutrophils (TANs) play a crucial role in tumor progression and exhibit prolonged survival. However, the mechanism underlying their extended lifespan significance laryngeal squamous cell carcinoma (LSCC) remains unclear. Herein, it is observed that apoptosis of TANs significantly delayed owing to induction by tumor‐derived G‐CSF GM‐CSF through activation PI3K‐AKT signaling pathway, upregulation anti‐apoptotic Mcl‐1 expression, downregulation activated Caspase‐3...
Background: The role of high mobility group A2 (HMGA2) in the progression hepatocellular carcinoma (HCC) is yet to be investigated, though tumor-associated macrophages (TAMs) are known mediate process. Methods: Immunohistochemistry (IHC), Western blot, and real-time PCR assays were performed identify HMGA2 TAMs markers. TAMs-like (TAMs-M&phis;s) triggered with help 25 ng/mL hM-CSF 50% NBCM. EdU assay wound healing assay, transwell TUNEL as well flow cytometry, carried out study effect or on...
Background: Neospora caninum, is the etiological agent of neosporosis, an infection that causes abortions in cattle and nervous system dysfunction dogs. Invasion egress are key steps pathogenesis N. caninum infection. Microneme proteins (MICs) play important roles recognition, adhesion, invasion host cells other apicomplexan parasites. However, some MICs their functions have rarely been reported. Methods: The homologous recombination strategy was used to investigate function MIC6 Results:...