Vesicular monoamine transporters (VMATs) mediate the transport of dopamine (DA), serotonin (5HT), and other monoamines into secretory vesicles. The regulation mammalian VMAT related vesicular acetylcholine transporter (VAChT) has been proposed to involve membrane trafficking, but mechanisms remain unclear. To facilitate a genetic analysis function regulation, we have cloned Drosophila homolog (dVMAT). We identify two mRNA splice variants (DVMAT-A B) that differ at their C-terminus, domain...

In Arabidopsis thaliana, blocking histidine biosynthesis with a specific inhibitor of imidazoleglycerol-phosphate dehydratase caused increased expression eight genes involved in the aromatic amino acids, histidine, lysine, and purines. A decrease glutamine synthetase was also observed. Addition eliminated gene-regulating effects inhibitor, demonstrating that changes gene resulted from histidine-pathway blockage. These results show plants are capable cross-pathway metabolic regulation.

Recent research has suggested that the absence of an intimate, confiding relationship may be a vulnerability factor in development depression women living under adverse circumstances. This study demonstrates significant association between severity and deficiencies marital intimacy; depressed patients with lowest levels intimacy failed to improve at one month follow-up, while 36% spouses had symptoms non-psychotic emotional illness. The their spouses' perception differ, but these differences...

Recovery is experienced in both positive and negative ways this paper attempts to integrate the 'pains of desistance' approach into a recovery capital framework. Pains as result are often thought stimulate motivations for behavioral change, usually through 'rock bottom' type moment. Whilst barriers have been explored literature, conceptualizing these push pull factors, exploring their dynamic interaction, especially at distinct phases has not. Toward filling gaps, we use life-narratives 30...

The majority of research on addiction recovery has been based male samples using traditional, structured methods and interviews. This study brings the voices women from diverse European countries to bring authentic lived experience into showcase their perspectives what constitutes journey how these sources are intertwined. employs Photovoice method as a participatory, arts-based approach examine experiences 17 backgrounds in UK, Sweden, Balkans, engaging participants throughout process. By...

There is growing evidence on the importance of a gendered understanding recovery. Gender differences have been reported in relation to nature and extent substance use, pathways through use disorder recovery capital acquisition maintenance. little existing research factors associated with growth by gender.

Introduction There is little research around recovery pathways and how they cluster together by individual situational factors according to time in recovery.

Abstract Conjugated linoleic acid (CLA) has been shown to inhibit tumorigenesis in animal models and is cytostatic numerous cell lines vitro . However, the mechanism of action unknown. In current study, we determined effects CLA specific isomers on rate oxygenation arachidonic by prostaglandin H synthase (PGHS) ram seminal vesicle microsomes. The enzyme was incubated with 0.1 100 μM or for 2 min prior addition 44 176 arachidonate. tested were 9( E ),11( ) CLA; Z CLA, 10( ),12( CLA. For a...

Cyanotic heart disease has major implications for maternal and fetal well-being during pregnancy. This article reports six patients with cyanotic congenital recently managed at our institutions. Although the condition deteriorated to some extent each pregnancy, it was that ultimately dictated delivery in case.

An approach to the design, development and implementation of a new separation technology for use in decontamination radioactive waste streams is reported here. Calixarene-crown-6 derivatives with terminal carboxyl groups were synthesised attached nano-sized magnetoferritin molecules their ability sequester caesium(I) ions from aqueous solution was demonstrated.

Epidemiological research has demonstrated that married individuals generally experience better emotional health than the single, divorced and widowed. The populations in these studies were not evaluated on basis of quality their marital relationships. Research interpersonal relationships general population rarely been reported psychiatric literature. A sample (n = 250 couples) completed a self-report questionnaire which measures quantity intimacy marriage. Four types patterns operationally...

Abstract The quality of sex and marital intimacy may be related to each other in ways which are not clearly understood. Some theorists have suggested that they vary positively with other. Others an independent relationship. Two hundred fifty couples the community completed Waring Intimacy Questionnaire (WIQ). Included WIQ is a qualitative assessment sexual communication fulfillment marriage. Weak positive correlations between total were found for both husbands (r = 41) wives 39). A principal...

The plasmodium of Physarum polycephalum is a large single cell visible with the naked eye. When inoculated on substrate attractants and repellents develops optimal networks protoplasmic tubes which span sites (i.e. nutrients) yet avoid domains high nutrient concentration. It should therefore be possible to program towards deterministic adaptive transformation internalised nano- micro-scale materials. In laboratory experiments magnetite nanoparticles glass micro-spheres coated silver metal...

Painful life events have been highlighted as being instrumental in promoting change during drug addiction recovery. This paper attempts to integrate the ‘pains of desistance’ approach into a recovery capital framework. It explores courses 30 people who had previously problem with an illicit substance explore role pains (potential push factors) alongside different forms (pull at key turning points Findings demonstrate that pull factors linked CHIME were significant positive changes. Turning...

Lack of intimacy in the marital relationship is hypothesized to be associated with presence symptoms nonpsychotic emotional illness one or both spouses. The development Waring Intimacy Questionnaire (WIQ) has furthered understanding between and illness. A clinical sample (n = 184) was compared a nonclinical 188) on quality quantity intimacy. reports significantly lower [F (1, 370) 37.5, p less than .001] deficient almost all aspects described, except sexuality. results suggest that WIQ...

Abstract The written diaries of 43 adult male respondents from a prison sample that had participated in restorative justice intervention reveal nuanced and dynamic process desistance via their hopes pains anticipated at the micro, meso macro levels. A utopian reading respondents’ is developed which reveals express vision not just personal, but also inherently political, radical, collective transformative. Their on other hand, critique condemnation current societal structural apparatus....