A5005477094- Pancreatic and Hepatic Oncology Research
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Renal Transplantation Outcomes and Treatments
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Immune cells in cancer
- Angiogenesis and VEGF in Cancer
- Liver Disease Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Organ Transplantation Techniques and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Sarcoma Diagnosis and Treatment
Zhejiang University
2019-2021
Blood Center of Zhejiang Province
2021
First Affiliated Hospital Zhejiang University
2019-2021
Pancreatic cancer is one of the most aggressive cancers worldwide with a high mortality rate. Prognosis remains poor even in this era advanced medicine mainly due to early metastasis and invasion. The present study aimed explore validate predictors distant prognosis pancreatic cancer. In our preliminary experiment, we established novel metastatic cell line BxPC‑M8 from parent BxPC‑3 cells. Via whole genome sequencing, RT‑qPCR, western blotting, migration invasion assays, initially found that...
We aimed to evaluate the whether AFP levels alone is an adequate screening indicator, or a combination of Generally, alpha-fetoprotein (AFP), CA19-9 and CEA could provide better diagnostic tool in detecting asymptomatic patients with primary hepatic cancer (PHC), also correlation degree differentiation serum biomarker levels.We retrospectively reviewed medical records 1362 form 2014-2018 who visited first Affiliated Hospital Zhejiang University, Hangzhou, China for health check-ups were...
Background: Current opinion suggests that expansion of cancer stem cells (CSCs) and activation pro-tumoral inflammation cascade correlate with progression. Materials methods: We explored the possible contributions MRC-5 cancer-associated fibroblasts to expression profiles CSC markers inflammation-associated cell surface molecules. The liver lines Bel-7402, SMMC-7721, MHCC-LM3, HepG2 cultured in conditioned medium (CM) from served as test groups, whereas normal control groups. Results: Flow...
Background: Liver cancer with portal vein tumor thrombus (PVTT) indicates a serious prognosis. The molecular mechanism of PVTT formation is not totally clarified, the invasion blood vessels by liver cells key step and endothelial plays critical role. Methods: Conditioned medium (CM) human umbilical (HUVEC) were used to culture prostate for cell motility viability analysis purpose simulating role macrovascular in development cancer. Results: HUVEC-CM caused long spindle-shaped changes cells;...
Background: Endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB) has become an important modality for identification of intra-abdominal masses.This study analyzed the accuracy EUS-FNAB in a single medical center and explored factors related to positive diagnosis.Materials methods: In total, 77 patients with were retrospectively reviewed from July 2016 February 2020."Atypical (tends be neoplasm/malignancy)," "suspicious (first consider "malignant" defined as cytology.The...
Objective False positive and negative results are associated with biliary tract cell brushing cytology during endoscopic retrograde cholangiopancreatography (ERCP). The causes uncertain. purpose of this study was to evaluate the accuracy diagnoses made via in our center, explore factors influencing diagnosis. Methods clinical data patients who underwent at center from January 2016 August 2019 were retrospectively analyzed. These included age, gender, stricture location, thickness bile duct...