Abstract Transplantation of mesenchymal stem cells (MSCs) was reported to improve functional outcomes in a rat model ischemic stroke, and subsequent studies suggest that MSC-derived microvesicles (MVs) can replace the beneficial effects MSCs. Here, we evaluated three different MVs, including MVs from untreated MSCs (MSC-MVs), treated with normal brain extract (NBE-MSC-MVs), stroke-injured (SBE-MSC-MVs), tested their on injury induced by permanent middle cerebral artery occlusion (pMCAO)...

The aims of this study were to determine the predictive value decision support analysis for shock wave lithotripsy (SWL) success rate and analyze data obtained from patients who underwent SWL assess factors influencing outcome by using machine learning methods. We retrospectively reviewed medical records 358 urinary stone (kidney upper-ureter stone) between 2015 2018 evaluated possible prognostic features, including patient population characteristics, characteristics on a non-contrast,...

Ataxia with oculomotor apraxia type 2 (AOA2) is caused by a diversity of mutations within the coding region senataxin gene. Recently, rare noncoding affecting RNA processing have been identified in AOA2. Here, we report case an 18-year-old woman, classic clinical features AOA2, who was found to harbor mutation intron 16. This disrupts local 5′ splice site architecture via novel intronic frameshift mechanism, causing skipping exon 16 predicted disruption conserved DNA/RNA helicase domain....

Serum prostate-specific antigen (PSA) is widely used in screening tests for prostate cancer. As the low specificity of PSA results unnecessary and invasive biopsies, we evaluated clinical significance various PSAs density (PSAD) related to peripheral zones patients with gray zone level (4-10 ng/mL).A total 1300 underwent transrectal ultrasonography-guided biopsy from 2014 2019. Among them, 545 were divided into cancer diagnosis group non-prostate group, PSA, relative extra transitional...

We have performed both open partial nephrectomy (OPN) and laparoscopic radiofrequency ablation (RFA) on selected patients since January 2007 been following these through serial laboratory assessments computed tomography (CT). The purpose of the present study was to evaluate long-term oncologic outcomes renal function status for RFA versus OPN at a minimum follow-up 3 years.A total 55 with exophytic, single small masses were treated either (n=14) or (n=41) by surgeon. indications as follows:...

Although metformin and sildenafil can protect various organs against ischemia/reperfusion (I/R) injuries, their effects mechanisms of action in bladder I/R injuries remain unknown. This study investigated the insults rats.One hundred male Sprague-Dawley rats were randomly divided into 5 groups, each which contained 20 rats: a sham-operated group, groups treated with metformin, sildenafil, or both agents. Ischemia was induced by clamping bilateral common iliac arteries atraumatic vascular...

Purpose: This clinical study sought to evaluate the possible effectiveness and practicality of URINO, an innovative, incisionless, disposable intravaginal device, designed for patients suffering from stress urinary incontinence.Methods: A prospective, multicenter, single-arm trial was carried out, involving women diagnosed with incontinence who used a self-inserted, pessary device. Comparisons were made between results 20-minute pad-weight gain (PWG) test at baseline visit 3, where device...

Purpose The aim of this study was to evaluate the applicability machine learning methods that combine data on age and prostate-specific antigen (PSA) levels for predicting prostate cancer. Materials Methods We analyzed 943 patients who underwent transrectal ultrasonography (TRUS)-guided biopsy at Chungnam National University Hospital between 2014 2018 because elevated PSA and/or abnormal digital rectal examination TRUS findings. retrospectively reviewed patients' medical records, prediction...

Objectives To evaluate the efficacy and safety of tamsulosin Hachimijiogan or Ryutanshakanto in patients with lower urinary tract symptoms due to benign prostatic hyperplasia. Methods A prospective, randomized, double‐blind method was used determine combination placebo at baseline 4, 8, 12 weeks study. The International Prostate Symptom Score, quality life index, complete voiding diary, National Institutes Health‐Chronic Prostatitis Index were studied. Uroflowmetery postvoid residual urine...

Many patients with benign prostatic hyperplasia require treatment for persistent storage symptoms, even when the obstruction is successfully relieved by surgery. Previous studies identified a characteristic increase in α1D-adrenoceptor levels bladder outlet (BOO) model. Here, we investigated expression of α1-adrenoceptor subtypes after relief partial BOO (pBOO) rat model.A total 60 female Sprague-Dawley rats were randomly divided into three groups (sham-operated, pBOO, and pBOO groups),...

We studied the long-term efficacy and safety of cystocele operation by polypropylene mesh. A total 198 women with stage ≥2 who had anterior vaginal wall repair transobturator four-arm mesh during 2003 to 2015 were evaluated. Outcomes including clinical characteristics complications reviewed extracting patient data from electronic medical records. In addition, telephone interviews conducted using a validated questionnaire along physical examination. The follow-up period was 9.3±0.3 years. in...

Background: In the present study, we investigated effect of dexmedetomidine on intubating conditions and hemodynamic changes during endotracheal intubation following anesthetic induction performed using propofol remifentanil without a neuromuscular blocking agent. Methods: We selected 70 adult patients aged 20 to 65 years scheduled undergo general anesthesia. Induction was 2 mg/kg 1.5 μg/kg remifentanil. The were divided into two groups, group (Group D) control C). Group D received an...

Aquaporin (AQP), a protein located in the cellular membrane, allows rapid passage of water across cell membrane. Various AQP subtypes have been associated with ureteral obstruction. In particular, AQP3 has two functions: and glycerol transport. The aim this study was to investigate expression ipsilateral rat kidney unilateral partial obstruction (UPUO).Sprague-Dawley rats (n=30, 200-250 g) were divided into groups. A sham operation performed control group (n=10) UPUO left upper ureter...

Purpose: We assessed the effectiveness and safety of using intravesical onabotulinumtoxinA (onabotA; BOTOX) injection with a low dose (75 units) for treating urinary storage symptoms in patients detrusor overactivity underactivity (DODU) compared to standard 100 units onabotA overactive bladder (OAB).Methods: This ambidirectional study included 121 female who received injections at our hospitals. A total 87 OAB 34 DODU were reviewed 3-day voiding diary, uroflowmetry, questionnaires including...

You have accessJournal of UrologyBladder & Urethra: Anatomy, Physiology Pharmacology (PD12)1 May 2024PD12-11 DISRUPTION OF METABOLIC AND URINARY FUNCTIONS IN MICE INDUCED BY CHRONIC MEALTIME SHIFT: IMPACT DAILY ANTIOXIDANT SUPPLEMENTATION Chung Lyul Lee, Hyun Seok Na, Ki Hak Song, Jae Sung Lim, Ju Shin, Jong Mok Park, Ji Yong Geun Gil and Khae Hwan Kim LeeChung Lee , NaHyun Na SongKi Song LimJae Lim ShinJu Shin ParkJong Park LeeJi LeeJae NaYong KimKhae View All Author...

Abstract BackgroundSerum prostate-specific antigen (PSA) is widely used in screening tests for prostate cancer. As the low specificity of PSA results unnecessary and invasive biopsies, we evaluated clinical significance various PSAs density (PSAD) related to peripheral zones patients with gray zone level (4-10 ng/mL).MethodsA total 1,300 underwent transrectal ultrasonography-guided biopsy from 2014 2019. Among them, 545 were divided into cancer diagnosis group non-prostate group, PSA,...

Endotracheal intubation sometimes leads to complications, particularly in patients with anticipated difficult intubation. The GlideScope is preferred because of its high success rate cases However, complications during the process have been reported. Most minor injuries can be treated after early detection. treatment if occur later. We report a patient who underwent an emergency tracheostomy due delayed airway obstruction caused by pharyngeal wall bleeding GlideScope. Keywords: Airway...

Castration-resistant prostate cancer (CRPC) is still a major concern in men's health, with 375,000 deaths annually. Hypoxia, which marked characteristic of advanced solid tumors, has been suggested to induce towards CRPC, metastasis and treatment resistance. To evaluate the effect hypoxia on cancer, two five cycles reoxygenation were administered using 22Rv1 cell lines denominated as 22Rv1-CI 22Rv1-PCI, respectively. Cancer migration was promoted compared controls, expression COL13A1...

Microvesicle (MVs) are submicron-sized membranous vesicles that either actively released from cells via secretory compartments or shed cell surface membranes. MVs generated by many types and serve as vehicles transfer biological information (e.g., protein, mRNA, miRNA) to distant cells, thereby affecting their gene expression, proliferation, differentiation, function. Although physiological functions not clearly defined, recent studies have shown therapeutic potential for tissue repair...

Purpose: Partial bladder outlet obstruction (PBOO) induces sustained over-distension, leading to ischemia/reperfusion (I/R)-related oxidative damage of the urothelium via apoptosis. The present study aimed investigate sequential course apoptosis in rat and identify changes apoptosis-related proteins during PBOO subsequent relief.  Materials Methods: was conducted using 60 female Sprague-Dawley rats divided into three groups: sham-operated, only, plus relief. induced for 2 weeks, then...

Bio-cells and tissues have intrinsic polarization characteristics, which are changed by external stimulus internal metamorphosis in cells some of the bio-cells birefringence also tissues. In this paper, we developed microscope for measurement relative phase results from characteristics materials with improved linear polarizing method measured distribution onion epidermal cells. From cells, decrease was investigated as elapse time. distribution, cell membrane decreased radically compared that...

To investigate whether a Percutaneous nephrostomy (PCN) has any impact on the success rate of shock wave lithotripsy (SWL) and to estimate probability stone-free in SWL patients with upper ureter stones.Overall, 236 who underwent for stones between 2015 2019 were evaluated. Forty-nine PCN during identified. Medical data retrospectively reviewed, possible prognostic features evaluated.Out all patients, 147 selected through propensity score matching. There no significant differences groups,...