A5049672417- Nerve injury and regeneration
- Blood Coagulation and Thrombosis Mechanisms
- Signaling Pathways in Disease
- Marine Biology and Environmental Chemistry
- Neuroinflammation and Neurodegeneration Mechanisms
- Nuclear Receptors and Signaling
- Protein Degradation and Inhibitors
- Parkinson's Disease Mechanisms and Treatments
- Adipose Tissue and Metabolism
- Nerve Injury and Rehabilitation
- Bioinformatics and Genomic Networks
- Botulinum Toxin and Related Neurological Disorders
- Protease and Inhibitor Mechanisms
- Lysosomal Storage Disorders Research
- Alzheimer's disease research and treatments
- Sirtuins and Resveratrol in Medicine
- Biological Research and Disease Studies
- Neurotransmitter Receptor Influence on Behavior
- Neurogenesis and neuroplasticity mechanisms
- Computational Drug Discovery Methods
- Neuroscience and Neuropharmacology Research
- Studies on Chitinases and Chitosanases
- 14-3-3 protein interactions
- Autophagy in Disease and Therapy
- Glutathione Transferases and Polymorphisms
University of Trieste
2024
University of Lisbon
2020-2023
Sapienza University of Rome
2013-2017
Background: The GSK3β has been associated to pathological functions in neurodegenerative diseases. This kinase is involved hyperphosphorylation of microtubule-associated tau protein, leading aggregation andformation NFTs. It clearly shown that regulated at posttranslational level: phosphorylation Tyr216 activates kinase, while Ser9 essential inhibit its activity. Keywords: GSK3β, phosphorylation, late onset Alzheimer's disease, DNA methylation, gene, Alzheimer patients, tau.
Abstract Trimethyltin (TMT) is a highly toxic molecule present as an environmental contaminant causing neurodegeneration particularly of the limbic system both in humans and rodents. We recently described occurrence impairment late stages autophagy TMT‐intoxicated astrocytes. Here we show that similarly to astrocytes also microglia, TMT induces precocious block indicated by accumulation autophagosome marker, microtubule associated protein light chain 3. Consistent with observe TMT‐treated...
Schwann cells (SC) are characterized by a remarkable plasticity that enables them to promptly respond nerve injury promoting axonal regeneration. In peripheral nerves after damage SC convert repair-promoting phenotype activating sequence of supportive functions drive myelin clearance, prevent neuronal death, and help axon growth guidance. Regeneration correlates inversely with thrombin levels. Thrombin is not only the key regulator coagulation cascade but also protease hormone-like...
Disruption of brain cholesterol homeostasis has been implicated in neurodegeneration. Nevertheless, the role Parkinson's Disease (PD) remains unclear. We have used N2a mouse neuroblastoma cells and primary cultures neurons 1-methyl-4-phenylpyridinium (MPP+), a known mitochondrial complex I inhibitor toxic metabolite 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), to trigger cascade events associated with PD neuropathological features. Simultaneously, we utilized other toxins, including...
<title>Abstract</title> Antidepressants are known for their neurotrophic effects, particularly through the regulation of brain-derived factor (BDNF) expression. Mirtazapine, a tetracyclic noradrenergic and specific serotonergic antidepressant (NaSSA) has been observed to upregulate BDNF, though its underlying mechanism remains unclear. In this study, we used human neuroblastoma SH-SY5Y cell line investigate whether mirtazapine could enhance BDNF translation by modulating serotonin and/or...
Peroxisome proliferator-activated receptor-gamma coactivator-1α (PGC-1α) transcriptional coactivators are key regulators of energy metabolism-related genes and expressed in energy-demanding tissues. There several PGC-1α variants with different biological functions The brain is one the tissues where role isoforms remains less explored. Here, we used a toxin-based mouse model Parkinson's disease (PD) observed that expression levels PGC-1α2 PGC-1α3 nigrostriatal pathway increases at onset...
Autophagy is generally considered a degradation pathway involved in many neurodegenerative processes. It can be observed different stress conditions such as starvation improving cell survival. Our previous results described the occurrence of autophagy neuronal cultures exposed to toxic compound trimethyltin (TMT) (1). TMT belongs family organotin compounds with wide industrial and agricultural applications, especially heat stabilizers PVC production biocides. In nervous system determines...
Protease-activated receptor-1 (PAR-1) is the prototypic member of a family four G-protein-coupled receptors that signal in response to extracellular proteases. In peripheral nervous system, expression and/or role PARs are still poorly investigated. High PAR-1 mRNA was found rat dorsal root ganglia and intensity increased sciatic nerve transection, both proximal distal part lesioned (1). Other authors revealed functional receptor exists specifically non-compacted Schwann cell myelin...
Schwann cells (SCs) regulate a wide variety of axonal functions in the peripheral nervous system, providing supportive growth environment following nerve injury (1). Here we show that rat SCs express protease-activated receptor-1 (PAR1) both vivo and vitro. PAR1 is G-protein coupled receptor eliciting cellular responses to thrombin other proteases (2). To investigate if activation affects neurotrophic properties SCs, this was activated by specific agonist peptide (TFLLR) conditioned medium...
This study is aimed at characterizing molecular pathways common to neurodevelopment and neurodegeneration. Indeed, it now evident that neurodegenerative processes can be rooted in aberrant expression of neurodevelopment-related genes. Among various genes, BDNF reelin are good candidates as they play fundamental roles during brain development/maturation adult functions their often altered On the other hand, PSEN1, which involved A β processing, also plays crucial developing brain. In this...
The peripheral nervous system has a striking regeneration potential and after damage extensive changes in the differentiation state both of injured neurons Schwann cells are observed. cells, particular, undergo large scale change gene expression becoming able to support axonal regeneration. Nerve injury is generally associated inflammation activation coagulation cascade. Thrombin acts as polyfunctional signalling molecule exerting its physiological function through soluble target proteins...