A5065746766- Fungal and yeast genetics research
- Plant Pathogens and Fungal Diseases
- Fungal Infections and Studies
- Plant and Fungal Interactions Research
- Plant Disease Resistance and Genetics
- Antifungal resistance and susceptibility
- Mycotoxins in Agriculture and Food
- Click Chemistry and Applications
- Yeasts and Rust Fungi Studies
- Computational Drug Discovery Methods
- Biofuel production and bioconversion
- Microbial Natural Products and Biosynthesis
- Plant-Microbe Interactions and Immunity
Acorn
2024
Texas A&M University
2013-2015
University of Georgia
2012-2014
In the fungal pathogen Cryptococcus neoformans, switch from yeast to hypha is an important morphological process preceding meiotic events during sexual development. Morphotype also known be associated with cryptococcal virulence potential. Previous studies identified regulator Znf2 as a key decision maker for formation and anti-virulence factor. By forward genetic screen, we discovered that long non-coding RNA (lncRNA) RZE1 functions upstream of ZNF2 in regulating yeast-to-hypha transition....
Cryptococcus neoformans is the etiologic agent of cryptococcal meningitis that causes more than half a million deaths worldwide each year. This capsulated basidiomycetous yeast also serves as model for micropathogenic studies. The ability to make stable mutants, either via ectopic integration or homologous recombination, has been accomplished using biolistic transformation. technical advance greatly facilitated research on basic biology and pathogenic mechanisms this pathogen in past two...
Ustilago maydis, causal agent of corn smut disease, is a dimorphic fungus alternating between saprobic budding haploid and an obligate pathogenic filamentous dikaryon. Maize responds to U. maydis colonization by producing tumorous structures, only within these does the sporulate, melanized sexual teliospores. Previously we identified Ust1, APSES (Asm1p, Phd1p, Sok2p, Efg1p, StuAp) transcription factor, whose deletion led growth production highly pigmented teliospore-like structures in...
Fungi have historically been the source of numerous important medicinal compounds, but full exploitation their genetic potential for drug development has hampered in traditional discovery paradigms. Here we describe a radically different approach, top-down (TD