A5016205597- RNA modifications and cancer
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Immunotherapy and Immune Responses
- HVDC Systems and Fault Protection
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Ginseng Biological Effects and Applications
- Pulmonary Hypertension Research and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related gene regulation
- Pharmacological Effects of Natural Compounds
- Renal cell carcinoma treatment
- Immune Cell Function and Interaction
- Protein Kinase Regulation and GTPase Signaling
- Cancer Immunotherapy and Biomarkers
- Kruppel-like factors research
- PI3K/AKT/mTOR signaling in cancer
- Peroxisome Proliferator-Activated Receptors
- Minimally Invasive Surgical Techniques
- Medicinal Plants and Bioactive Compounds
Wenzhou Medical University
2012-2024
Zhejiang Taizhou Hospital
2024
Shanxi Medical University
2021
North China University of Science and Technology
2020
Eastern Hepatobiliary Surgery Hospital
2017
Second Military Medical University
2017
Increasing evidence has demonstrated that aberrant expressions of long non-coding RNAs (lncRNAs) are involved in various malignancies, including hepatocellular carcinoma (HCC). This study aimed to investigate the role lncRNA colon cancer-associated transcript 2 (CCAT2) progression HCC. Quantitative real-time polymerase chain reaction analysis confirmed CCAT2 was upregulated HCC cell lines and cancerous tissues compared with normal liver line adjacent tissue samples. The level positively...
Abstract Background Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide, it has a poor prognosis due to its highly invasive and metastatic nature. Consequently, identifying effective prognostic markers potential therapeutic targets been extensively investigated. METTL5, an 18S rRNA methyltransferase, abnormally high in HCC. But biological function significance HCC remain largely unelucidated. This study aimed investigate role METTL5 progression, elucidate...
BACKGROUNDIntestinal inflammation is a common digestive tract disease, which usually treated with hormone medicines.Hormone medicines are effective to some extent, but long-term use of them may bring about many complications. AIMTo explore the protective effects panax notoginseng saponin (PNS) against dextran sulfate sodium (DSS)-induced intestinal inflammatory injury through phosphoinositide-3-kinase protein kinase B (PI3K/AKT) signaling pathway inhibition in rats. METHODSColitis rat models...
ObjectiveTo explore the relationships between hepatocellular carcinoma (HCC) and expression of RNA polymerase II subunit 3 (RPB3) vesicular, overexpressed in cancer, prosurvival protein 1 (VOPP1), to determine whether RPB3 regulates VOPP1 promote HCC cell proliferation, tumor growth, tumorigenesis.MethodsHCC adjacent liver samples were collected from 51 patients with who underwent surgical excision September 20, 2010 June 22, 2017. Immunohistochemical staining, western blot, quantitative...
Objective To investigate the clinical significance of human leukocyte antigen (HLA)-E levels in oesophageal squamous cell carcinoma (ESCC). Methods The HLA-E immunostaining ESCC lesions and 47 corresponding adjacent normal tissues were measured using immunohistochemistry. correlation between parameters was analysed. Results This study analysed 110 paraffin-embedded primary tumour case–controlled paracancerous that surgically resected from patients with ESCC. Positive for observed 88.2% (97...
Objective To study the safety and feasibility of laparoscopic left lateral sectionectomy using Glissonian pedicel approach.Methods The root round ligament liver was exposed section dissected,starting from lapa roscopic Peng's multifunctional operative dissector (LPMOD).After segment Ⅱ Ⅲ dissected,clipped cut,the ischemic boundary showed up.The transected at liver,and hepatic vein its branches were cut. Resutts surgery successtully performed in 8 patients.There no conversion to open...
Objective To evaluate the feasibility and safety of laparoscopic right hemihepatectomy under selective hemihepatic inflow occlusion.Methods In performing this procedure,first dissect hepatic portal,and occlusion,laparoscopie Peng's multifunctional operative dissector (LPMOD) was used to transect parenchyma by stepwise curettage aspiration.Results Procedures were successful in all six patients benign liver diseases,though a small subcostal auxiliary incision needed one case control middle...
Abstract Objective: Late post-pancreatoduodenectomy hemorrhage (LPPH) is associated with a significant increase in perioperative mortality. It of great significance to explore effective treatment methods for severe LPPH patients. Methods: Between 2014 and 2021, 224 pancreatoduodenectomies were performed, 14 patients had late (occurring >24 h postoperatively). The clinicopathological variables treatments related investigated. Results: Out the patients, 6 grade B 8 C hemorrhage. There 11...
Abstract Background This study is designed to examine the role of Krüppel-like factor 4 in mediating proliferation pulmonary artery smooth muscle cells (PASMCs) hypoxic hypertension and underlying mechanisms. Methods Experiments were conducted using PASMCs isolated from male Sprague-Dawley rats. The divided into 24 h group, 48 group 72 according different hypoxia treatment time. For specific inhibition ERK1/2 p38 signaling pathways, treated with ERK1/2-specific inhibitor. KLF4 was cloned...