A5067660036- Spaceflight effects on biology
- Effects of Vibration on Health
- Muscle metabolism and nutrition
- Cardiovascular and exercise physiology
- Glycogen Storage Diseases and Myoclonus
- Advanced MRI Techniques and Applications
- Genetic Neurodegenerative Diseases
- Musculoskeletal pain and rehabilitation
- High Altitude and Hypoxia
- Muscle activation and electromyography studies
- Mitochondrial Function and Pathology
- Sports Performance and Training
- Occupational Health and Performance
- Muscle Physiology and Disorders
- Ergonomics and Musculoskeletal Disorders
- Metabolism and Genetic Disorders
- Noise Effects and Management
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Nutrition and Health in Aging
- Body Composition Measurement Techniques
- Spine and Intervertebral Disc Pathology
- Neurological disorders and treatments
- Physiological and biochemical adaptations
- Thermoregulation and physiological responses
- Space Exploration and Technology
Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR)
2015-2025
University of Cologne
2007-2021
Aerospace Institute (Germany)
2013
Ruhr University Bochum
2006-2013
Ludwig-Maximilians-Universität München
2006
Linde (Germany)
2005
Saft (France)
2005
Dienstleistungszentrum Ländlicher Raum
1999
Heidelberg University
1996
Institute of Pharmacology
1996
Abstract Huntington's disease (HD) is an autosomal dominantly inherited neurodegenerative disorder caused by a CAG repeat expansion in the IT‐15 gene; however, it remains unknown how mutation leads to selective neurodegeneration. Several lines of evidence suggest impaired mitochondrial function as component process HD. We assessed energy metabolism skeletal muscle 15 HD patients and 12 asymptomatic carriers vivo using 31P magnetic resonance spectroscopy. Phosphocreatine recovery after...
Objective: To determine whether treatment with creatine can improve exercise intolerance in myophosphorylase deficiency (McArdle disease).Design: Double-blind, placebo-controlled crossover study oral monohydrate supplementation.Patients: Nine patients biochemically and genetically proven McArdle disease were treated.Intervention: Five days of daily high-dose intake (150 mg/kg body weight) followed by lowdose (60 mg/kg).Each phase or placebo lasted 5 weeks. Main Outcome Measures:The effect...
Background: In a recent study, we showed that administration of low-dose creatine (Cr) (60 mg/kg daily) improved work capacity in patients with McArdle disease.Objective: To assess the efficacy high-dose Cr therapy disease.Design: Randomized, double-blind, placebo-controlled crossover study.Patients: Nineteen disease.Intervention: Treatment Cr, 150 daily.Each treatment phase or placebo lasted 5 weeks.Main Outcome Measures: The patient's daily rating symptoms exercise intolerance.At end each...
Exposure to artificial gravity (AG) in a short-arm centrifuge has potential benefits for maintaining human performance during long-term space missions. Eleven subjects were investigated three campaigns of 5 days head-down bed rest: 1) rest without countermeasures (control), 2) and 30 min AG (AG1) daily, 3) six periods (AG2) daily. During centrifugation, the supine exposed head-to-feet direction with 1 G at center mass. Subjects participated random order. The cardiovascular effects determined...
Prolong exposure to weightlessness leads loss of muscle and bone mass. Therefore, astronauts on board the International Space Station (ISS) currently perform mandatory daily exercises. ISS missions usually last 6 months, future will become significantly longer when going, for example, Mars. To that purpose, an exoskeleton-based exercise device, called ATHLETIC, was developed. The functionality relevance this device evaluated in study. Ten participants performed resistance exercises (squats)...
Abstract Age‐related deterioration in muscle volume, intramuscular fat content and function can be modulated by physical activity. We explored whether Masters athletes, as examples of highly physically active people into old age, could prevent these age‐related deteriorations. Four groups 43 men were examined: young athletes (20–35 years, n = 10), (60–75 10) two age‐matched control (old: 11, young: 12). Volumes fractions 17 different hip leg muscles determined using magnetic resonance...
The present study evaluated the effectiveness of a short and versatile daily exercise regime, named locomotion replacement training (LRT), to maintain muscle size, isometric strength, power, endurance capacity leg muscles following 5 days head-down tilt (HDT) bed rest. 10 male subjects (age 29.4 ± 5.9 years; height 178.8 3.7 cm; body mass 77.7 4.1 kg) performed, in random order, 6° rest (BR) with no (CON), or BR 25 min upright standing (STA) LRT. Knee extensor plantar flexor cross-sectional...
We describe the first non-Ashkenazi patient with adult polyglucosan body disease and decreased glycogen-branching enzyme (GBE) activity in leukocytes. Gene analysis revealed compound heterozygosity for two novel missense mutations Arg515His Arg524Gln GBE gene. Both are predicted to impair activity. This is identification of underlying a family, confirms that glycogen storage type IV can manifest clinically as disease. Ann Neurol 2000;47:536–540.
The purpose of our randomized, double‐blind, placebo‐controlled crossover study in 15 patients with chronic progressive external ophthalmoplegia (CPEO) or Kearns–Sayre syndrome (KSS) because single large‐scale mitochondrial (mt) DNA deletions was to determine whether oral creatine (Cr) monohydrate can improve skeletal muscle energy metabolism vivo . Each treatment phase Cr a dosage 150 mg/kg body weight/day placebo lasted 6 weeks. effect estimated by phosphorus‐31 magnetic resonance...
Key words Magnetic resonance imaging - magnetic spectroscopy 31P MRS skeletal muscle microgravity exercise energy metabolism
As part of the nutrition-countermeasures (NUC) study in Cologne, Germany 2010, seven healthy male subjects underwent 21 days head-down tilt bed rest and returned 153 later to undergo a second bout 21-day rest. this model, we aimed examine recovery lumbar intervertebral discs muscle cross-sectional area (CSA) after using magnetic resonance imaging conduct pilot on effects activation, as measured by signal intensity changes T(2)-weighted images standardized isometric spinal extension loading...
We measured significant undershoots of the concentrations free ADP ([ADP]) and P i ([P ]) energy ATP hydrolysis (Δ G ) below initial resting levels during recovery from severe ischemic exercise with 31 P-nuclear magnetic resonance spectroscopy in 11 healthy sports students. Undershoots rate oxidative phosphorylation would be predicted if depend solely on [ADP], [P ], or Δ . However, have not been reported literature. Furthermore, are unlikely because there is evidence that a balance between...
Astrocytes are the most abundant cells in CNS, and have many essential functions, including maintenance of blood–brain barrier integrity, CNS water, ion, glutamate homeostasis. Mammalian astrogliogenesis has generally been considered to be completed soon after birth, reactivated later life only under pathological circumstances. Here, by using genetic fate-mapping, we demonstrate that new corpus callosum astrocytes continuously generated from nestin<sup>+</sup> subventricular zone (SVZ)...
Abstract Purpose Spaceflight impairs physical capacity. Here we assessed the protective effect of artificial gravity (AG) on aerobic exercise capacity and muscle function during bed rest, a spaceflight analogue. Methods 24 participants (33 ± 9 years, 175 cm, 74 10 kg, 8 women) were randomly allocated to one three groups: continuous AG (cAG), intermittent (iAG) or control (CTRL). All subjected 60 days six-degree head-down tilt subjects intervention groups completed 30 min centrifugation per...