This study investigated the in vitro and vivo antioxidant anti-inflammatory properties of a juice blend (JB), MonaVie Active, containing mixture fruits berries with known activity, including açai, palm fruit, as predominant ingredient. The phytochemical antioxidants JB are primarily form anthocyanins, predominantly cyanidin 3-rutoside, 3-diglycoside, 3-glucoside. cell-based protection erythrocytes (CAP-e) assay demonstrated that penetrated protected cells from oxidative damage (p < 0.001),...

It has been demonstrated that some strains of Bacillus coagulans can survive extremes heat, acidity the stomach, and bile acids, to which commonly consumed probiotics are susceptible. A toxicological safety assessment was performed on a proprietary preparation B. - GanedenBC(30) novel probiotic. Seven toxicologic studies were conducted included: in vitro bacterial reverse mutation assay; chromosomal aberration micronucleus assay mice; acute 90 day subchronic repeated oral toxicity Wistar...

Abstract Background This study was performed to evaluate anti-inflammatory and immune modulating properties of the probiotic, spore-forming bacterial strain: Bacillus coagulans : GBI-30, (PTA-6086, GanedenBC30TM). In addition, cell wall metabolite fractions were assayed separately address whether biological effects due components only, or secreted compounds from live bacteria had additional properties. The spores heat-activated, cultures grown. culture supernatant harvested as a source...

The objective of this study was to compare three tests frequently used for evaluation antioxidant potential in natural products: (1) oxygen radical absorbance assay (ORAC), (2) cell-based protection an erythrocyte model (CAP-e), and (3) reactive species formation polymorphonuclear cells (ROS PMN). methods were applied four products, all containing antioxidants capable entering protecting the CAP-e assay. magnitude effect not directly correlated ORAC value each product. Furthermore, products...

Osteoarthritis (OA) is a significant source of pain and disability. Current medical surgical treatments can be costly have serious side effects. The aim this randomized, double-blind, placebo-controlled trial was to investigate the tolerability efficacy BioCell Collagen (BCC), low molecular weight dietary supplement consisting hydrolyzed chicken sternal cartilage extract, in treatment OA symptoms. Patients (n = 80) study had physician-verified evidence progressive their hip and/or knee...

There is a current worldwide interest in developing novel sustainable nonanimal nutritional sources, and one such source the green algae Chlamydomonas reinhardtii, only that has been studied as model organism for many biological processes ranging from photosynthesis to flagellar movement. However, its potential safe use various foods not thoroughly investigated. To assess safety of C reinhardtii human food ingredient, accordance with internationally accepted standards, genotoxic...

Humic substances are ubiquitous in soils and waters. These complex superstructures derived from the decomposition of dead plant animal matter vital to soil health. Their heterogenous composition is specific their site origin comprised weakly bound aggregates small organic compounds that can sequester minerals make them available plants. As such, they may possess potential nutritional value for humans, extractions fulvic humic acids be produced could suitable such purposes. For this reason,...

Abstract Age‐related deterioration in muscle volume, intramuscular fat content and function can be modulated by physical activity. We explored whether Masters athletes, as examples of highly physically active people into old age, could prevent these age‐related deteriorations. Four groups 43 men were examined: young athletes (20–35 years, n = 10), (60–75 10) two age‐matched control (old: 11, young: 12). Volumes fractions 17 different hip leg muscles determined using magnetic resonance...

Some strains of Bacillus coagulans can survive extremes heat, stomach acid and bile acids, to which commonly consumed probiotics are susceptible. A toxicological safety assessment was published in 2009 on a proprietary preparation B. - GanedenBC(30)™ novel probiotic. It concluded that is safe for chronic human consumption based upon scientific procedures, supported by history use (Endres et al., 2009). one-year oral toxicity study combined with one-generation reproduction conducted further...

Natural Eggshell Membrane (NEM®) is a novel dietary ingredient that contains naturally occurring glycosaminoglycans and proteins essential for maintaining healthy joint connective tissues. NEM® was evaluated safety via in vitro vivo toxicological studies. This included testing cytotoxicity, genotoxicity, acute oral toxicity, 90-day repeated-dose toxicity. did not exhibit any cytotoxic effects at dose of 100 μg an human cell viability assay after incubation up to 20 h. genotoxic four strains...

A battery of toxicological studies was conducted on a supercritical CO 2 extract the aerial parts Cannabis sativa plant, containing approximately 25% cannabinoids. No evidence genotoxicity found in bacterial reverse mutation test (Ames), an vitro mammalian chromosomal aberration test, or vivo mouse micronucleus study. 14-day repeated oral dose-range finding study Wistar rats at 1000, 2000, and 4000 mg/kg bw/day resulted effects where NOAEL could not be concluded. Based those results, 90-day...

A battery of OECD- and GLP-compliant toxicological studies was performed on mango leaf extract (Mangifera indica) containing 60% mangiferin (MLE). No evidence genotoxicity found in a bacterial reverse mutation test (Ames). While clastogenic activity noted an vitro chromosomal aberration test, vivo mammalian micronucleus showed no findings up to the limit dose (2000 mg/kg bw). 90-day repeated oral toxicity study conducted rats using doses 0 (vehicle control), 500, 1000, 2000 bw/day. Based...

A battery of toxicological studies was conducted to investigate the genotoxicity and repeated-dose oral toxicity Bonolive™, a proprietary water-soluble extract leaves olive tree ( Olea europaea L.), in accordance with internationally accepted protocols. There no evidence mutagenicity bacterial reverse mutation test an vitro mammalian chromosomal aberration nor any genotoxic activity observed vivo mouse micronucleus at concentrations up limit dose 2000 mg/kg bw/d. Bonolive™ did not cause...

A battery of toxicological studies was conducted in accordance with internationally accepted standards to investigate the genotoxicity and repeated-dose oral toxicity Fernblock(®), a commercial aqueous extraction leaves tropical fern Polypodium leucotomos used for its topical photoprotective properties. No evidence mutagenicity observed bacterial reverse mutation test or vitro mammalian chromosomal aberration nor any genotoxic activity an vivo mouse micronucleus test. Two were male female...

A well-characterized standardized hydroethanolic extract of a traditionally recognized mak (mild) variety Sceletium tortuosum, South African plant with long history traditional ingestion, is marketed under the trade name Zembrin(®) as an ingredient for use in functional foods and dietary supplements. It to contain 0.35-0.45% total alkaloids (mesembrenone mesembrenol ≥60%, mesembrine <20%). 14-day repeated oral toxicity study was conducted at 0, 250, 750, 2500, 5000 mg/kg bw/day. 90-day...

Morus alba L. (white mulberry) leaves are one of the oldest recognized traditional Chinese medicines. More recently, M and their constituents, particularly iminosugars (or azasugars), have garnered attention for ability to maintain normal blood glucose concentrations, an effect identified in both animal studies human clinical trials. Reducose (Phynova Group Limited) is a commercial water-soluble extract standardized 5% 1-deoxynojirimycin (DNJ), iminosugar with α-glucosidase inhibition...

Microorganisms have the potential to produce nutrient-rich products that can be consumed as food or feed. The protein-rich powder derived from heat treatment of whole-cell biomass polyhydroxybutyrate-deficient Cupriavidus necator, a metabolically versatile organism uses elements found in air, is an example such product. To assess safety protein for use nutritional ingredient human food, accordance with internationally accepted standards, its genotoxic and repeated-dose oral toxicity were...

The dietary supplement Citicoline free-base (choline cytidine 5′-pyrophosphate) was toxicologically evaluated in Sprague-Dawley rats using oral gavage. In an acute 14-day study, 2000 mg/kg well tolerated. a 90-day 100, 350, and 1000 mg/kg/day doses resulted no mortality. males, slight significant increases serum creatinine (350 mg/kg/day), decreases urine volume (all treated groups) were observed. females, total white blood cell absolute lymphocyte counts (1000 urea nitrogen (BUN) (100 but...

Insurance claims resulting from lightning damage in Colorado, Utah, and Wyoming were analyzed during the period 1987 to 1993. Most personal accounts, while some commercial. Lightning three states resulted an annual average of 6755 being filed. more than half Denver metropolitan area. Over $7 million a year losses occurred for these types insurance policies when $150 deductible was included; most Colorado. The value paid per claim $916 all claims; commercial averaged $1369, $873. One...

L-(+)-ergothioneine has antioxidant and anti-inflammatory properties in vitro vivo uses as a dietary supplement an ingredient foods, cosmetics, pharmaceutical additive. The clastogenic potential mutagenic of ergothioneine were assessed vivo. Ergothioneine concentrations up to 5000 μg/mL, with without metabolic activation, was tested the chromosome aberration assay CHL cells found not induce structural aberrations. In mammalian erythrocyte micronucleus test, administered orally male mice at...

A 90-day repeated-dose oral toxicological evaluation was conducted according to GLP and OECD guidelines on the methylurate purine alkaloid theacrine, which is found naturally in certain plants. Four groups of Hsd.Brl.Han Wistar rats (ten/sex/group) were administered theacrine by gavage doses 0 (vehicle only), 180, 300, 375 mg/kg bw/day. Two females one male 300 bw/day groups, respectively, died during study. Histological examination revealed centrilobular hepatocellular necrosis as probable...

Abstract Interest in microalgae products for use food is increasing, as demands sustainable and cost‐effective choices grow due to the escalating global population increase climate‐related struggles with agriculture. Toxicological assessments of some species have been conducted, but there were little data available oral consumption red Porphyridium purpureum no on genotoxicity. This article articulates a genotoxicity assessment 90‐day repeated dose toxicity study rats performed according...

A battery of OECD- and GLP-compliant toxicological studies was performed to assess the safety a highly purified germanium sesquioxide, an organic form naturally occurring, nonessential trace element germanium. Germanium dioxide lactate citrate (inorganic germaniums) have been shown induce renal toxicity, whereas sesquioxide (an germanium) has more favorable profile. However, past toxicity on compounds not clearly stated purity tested compounds. In reported herein, there no evidence...