A5101906443- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Ubiquitin and proteasome pathways
- Fiber-reinforced polymer composites
- Circular RNAs in diseases
- DNA Repair Mechanisms
- Sarcoma Diagnosis and Treatment
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- interferon and immune responses
- Cancer Immunotherapy and Biomarkers
- Cell Adhesion Molecules Research
- Genomics and Chromatin Dynamics
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Genetic Neurodegenerative Diseases
- Electrospun Nanofibers in Biomedical Applications
- TGF-β signaling in diseases
- Wnt/β-catenin signaling in development and cancer
- Cancer Cells and Metastasis
- Silk-based biomaterials and applications
- Additive Manufacturing and 3D Printing Technologies
- Polydiacetylene-based materials and applications
- Extracellular vesicles in disease
The University of Texas Southwestern Medical Center
2019-2024
Second Affiliated Hospital of Nanchang University
2023-2024
Nanchang University
2023-2024
Jilin University
2022-2023
Jinan University
2023
Medical Architecture (United Kingdom)
2023
Cancer is instigated by mutator phenotypes, including deficient mismatch repair and p53-associated chromosomal instability. More recently, a distinct class of cancers was identified with unusually high mutational loads due to heterozygous amino acid substitutions (most commonly P286R) in the proofreading domain DNA polymerase ε, leading strand replicase encoded POLE. Immunotherapy has revolutionized cancer treatment, but new model systems are needed recapitulate burdens characterizing human...
Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by expanded CAG repeat in the huntingtin ( HTT ) gene. The repeat-expanded encodes a mutated (mHTT), which known to induce DNA double-strand breaks (DSBs), activation of cGAS–STING pathway, and apoptosis HD. However, mechanism mHTT triggers these events unknown. Here, we show that interacts with both exonuclease 1 (Exo1) MutLα (MLH1–PMS2), negative regulator Exo1. While HTT–Exo1 interaction suppresses Exo1-catalyzed...
Abstract Idiopathic short stature (ISS) is a common childhood condition with largely unknown underlying causes. Recent research highlights the role of circulating exosomes in pathogenesis various disorders, but their connection to ISS remains unexplored. In experiments, human chondrocytes are cocultured plasma from patients, leading impaired chondrocyte growth and bone formation. Elevated levels specific long non‐coding RNA (lncRNA), ISSRL, identified as distinguishing factor ISS, boasting...
Vessel co-option is responsible for tumor resistance to antiangiogenic therapies (AATs) in patients with colorectal cancer liver metastasis (CRCLM). However, the mechanisms underlying vessel remain largely unknown. Herein, we investigated roles of a novel lncRNA SYTL5-OT4 and Alanine-Serine-Cysteine Transporter 2 (ASCT2) co-option-mediated AAT resistance.SYTL5-OT4 was identified by RNA-sequencing verified RT-qPCR RNA fluorescence situ hybridization assays. The effects ASCT2 on cells were...
Weak interfacial activity and poor wettability between fiber matrix are known to be the two main factors that restrict mechanical properties of carbon fiber-reinforced composites (CFRCs). Herein, inspired by high strength toughness characteristics wing feathers Black Kite (Milvus migrans), natural hook-groove microstructure system (HGMS) underlying interlocking mechanism were carefully investigated. Biomimetic HGMS based on dopamine-functionalized fibers ZnO nanorods constructed successfully...
Currently, the etiology of idiopathic short stature (ISS) is still unclear. The poor understanding molecular mechanisms ISS has largely restricted this strategy towards safe and effective clinical therapies.The plasma exosomes children were co-cultured with normal human chondrocytes. differential expression exosome miRNA between was identified via high-throughput microRNA sequencing bioinformatics analysis. Immunohistochemistry, In situ hybridization, RT-qPCR, western blotting, luciferase...
Osteosarcoma (OS) patients, particularly those with distant metastasis, experience rapid progression and derive poor survival benefits from traditional therapies.Currently, effective drugs for treating patients metastatic OS remain scarce.Here, we found that the cyclic hexadepsipeptide beauvericin (BEA) functioned as a new selective TGFBR2 inhibitor potent antiproliferative antimetastatic activities against cells.Functionally, BEA inhibited TGF-β signaling-mediated proliferation,...
Mismatch repair (MMR) is a replication-coupled DNA mechanism and plays multiple roles at the replication fork. The well-established MMR functions include correcting misincorporated nucleotides that have escaped proofreading activity of polymerases, recognizing nonmismatched adducts, triggering damage response. In an attempt to determine whether regulates progression in cells expressing ultramutable polymerase ɛ (Polɛ), carrying proline-to-arginine substitution amino acid 286 (Polɛ-P286R), we...