A5005073951- Pharmacological Effects of Natural Compounds
- Biological Activity of Diterpenoids and Biflavonoids
- Phytochemistry and Biological Activities
- Chemical Synthesis and Reactions
- Natural product bioactivities and synthesis
- Botulinum Toxin and Related Neurological Disorders
- Tissue Engineering and Regenerative Medicine
- Neurological disorders and treatments
- Electrospun Nanofibers in Biomedical Applications
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Oxidative Organic Chemistry Reactions
- Asymmetric Synthesis and Catalysis
- Lipid Membrane Structure and Behavior
- Metabolism, Diabetes, and Cancer
- Plant biochemistry and biosynthesis
- Synthesis of heterocyclic compounds
- Atrial Fibrillation Management and Outcomes
- Zeolite Catalysis and Synthesis
- Crystallization and Solubility Studies
- Synthesis of Organic Compounds
- Biochemical and Molecular Research
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Infectious Aortic and Vascular Conditions
- Synthetic Organic Chemistry Methods
Novosibirsk Institute of Organic Chemistry
2006-2025
Institute of Chemical Kinetics and Combustion
2024
Meshalkin National Medical Research Center
2018-2020
Ministry of Health of the Russian Federation
2018-2020
Infectious Clinical Hospital No. 1
2019
Khabarovsk State University of Economics and Law
2019
Russian Academy of Sciences
2006-2009
Institute of Geology Ufa Scientific Center
1989-1994
This study presents a novel method to enhance the biocompatibility of decellularized porcine aortic segments while preserving their mechanical properties and histological structure. Detergent-decellularized were treated with modified globular chitosan (Novochizol™) at varying concentrations (0.5%, 1%, 2%, 3%) by sonication subsequently subjected testing. To further improve cell infiltration, blind-ended laser channels created within segments. The grafts then seeded vascular interstitial...
When developing drugs against SARS-CoV-2, it is important to consider the characteristics of patients with different co-morbidities. People infected HIV-1 are a particularly vulnerable group, as they may be at higher risk than general population contracting COVID-19 clinical complications. For such patients, broad spectrum antiviral activity paramount importance. Glycyrrhizinic acid (Glyc) and its derivatives promising biologically active compounds for development broad-spectrum agents. In...
Several experimental studies have recently demonstrated that temporary autonomic block using botulinum toxin (BoNT/A1) might be a novel option for the treatment of atrial fibrillation. However, assessment antiarrhythmic properties BoNT has so far been limited, relying exclusively on vagal stimulation and rapid pacing models. The present study examined effect specially formulated BoNT/A1-chitosan nanoparticles (BTN) in calcium chloride-, barium chloride- electrically induced arrhythmia rat...
The reactions of (−)-β-pinene (1) with some methyl- and hydroxy-substituted phenols on Hβ-zeolite yield optically active products – tricyclic terpenyl phenyl ethers in contrast to homogeneous media, which occur loss optical activity. formation these is promoted by the presence meta-substituents phenol molecule.
Currently, several materials for the closure of dura mater (DM) defects are known. However, long-term results their usage reveal a number disadvantages. The use antibiotics and chitosan is one major trends in solving problems associated with infectious after-operational complications. This work compares mechanical properties samples bacterial nanocellulose (BNC) impregnated Novochizol™ vancomycin native BNC preserved human DM. An assessment possibility controling these by changing thickness...
The epoxidation of turpentine (technical α-pinene), 3-carene, and limonene with aqueous hydrogen peroxide was studied in a new catalytic system employing manganese sulfate, salicylic acid, sodium bicarbonate, acetonitrile, as polar solvent. proposed approach makes it possible to carry out “chemical separation” components, yielding valuable individual derivatives monoterpenes without the need isolate monoterpene reagents. Specific methods have been developed for production α-pinene epoxide,...
The use of biological plant protection products is promising for agriculture. In particular, chitosan-based biopesticides have become widespread stimulating growth and protecting plants from a wide range pathogens. Novochizol product obtained by intramolecular cross-linking linear chitosan molecules has globular shape, which provides it with number advantages over chitosan. previously been shown to effect on the development common wheat (Triticum aestivum L.). However, this preparation...
Dual PPARα/γ agonists can normalize both glucose and lipid metabolism in patients with type 2 diabetes mellitus. The development of such drugs faced the detection various toxic effects phase III clinical trials. However, two this class managed to pass all stages trials, which makes search for new dual promising. In present study, a series dihydrobetulonic acid amides differing length amino-alcohol linker incorporating pharmacophore fragment (S)-2-ethoxy-3-phenylpropanoic were synthesized....
This study presents a novel method to enhance the biocompatibility of decellularized porcine aortic segments while preserving their mechanical properties and histological structure. Detergent-decellularized were treated with modified globular chitosan (Novochizol™) at varying concentrations (0.5%, 1%, 2%, 3%) by sonication subsequently subjected testing. To further improve cell infiltration, blind-ended laser channels created within segments. The grafts then seeded vascular interstitial...
The use of biological plant protection products is promising for agriculture. In particular, chitosan-based biopesticides have become widespread stimulating growth and protecting plants from a wide range pathogens. Novochizol product obtained by intramolecular cross-linking linear chitosan molecules has globular shape, which provides it with number advantages over chitosan. previously been shown to effect on the development common wheat (
We conducted a comparative analysis of the parenteral viral hepatitis B and C (HBV HCV) prevalence their molecular genetic characteristics among prisoners persons diagnosed with HIV infection (41 samples), HIV-positive free citizens (187 samples) «conditionally healthy population» lack information about presence diagnosis chronic any etiology (231 samples). Immunological biological research methods were used. Obtained data showed that markers viruses was significantly higher in groups...
A series of triterpenic acid amides were synthesized incorporating a 2-ethoxy-3-phenylpropanoic pharmacophore fragment. The compounds tested for their ability to improve glycemic control and counter lipid abnormalities in C57BL/6 mice placed on high-fat/high-cholesterol diet. Of all compounds, the dihydrobetulonic derivative (16b) had most pronounced effect decreasing blood glucose levels, total cholesterol (TC), high-density lipoproteins (HDL). All displayed relatively safe profile animal...
The reactions of the natural sesquiterpene caryophyllene with phenols on various solid acid catalysts gave corresponding terpenylphenols and phenyl terpenyl ethers essentially caryolane structures. selectivity process yield product can be raised by varying catalyst solvent.
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