A5101999784- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Cold Atom Physics and Bose-Einstein Condensates
- T-cell and B-cell Immunology
- Gold and Silver Nanoparticles Synthesis and Applications
- Physics of Superconductivity and Magnetism
- Mitochondrial Function and Pathology
- Neurogenesis and neuroplasticity mechanisms
- Immune Cell Function and Interaction
- Engineering and Environmental Studies
- Material Properties and Applications
- Intermetallics and Advanced Alloy Properties
- Tryptophan and brain disorders
- Fluid Dynamics and Turbulent Flows
- Spinal Cord Injury Research
- Ion Transport and Channel Regulation
- Viral Infections and Immunology Research
- Memory and Neural Mechanisms
- Material Properties and Failure Mechanisms
- RNA Interference and Gene Delivery
- Cancer Immunotherapy and Biomarkers
- Industrial Engineering and Technologies
- Metallurgical Processes and Thermodynamics
- Surface Chemistry and Catalysis
Jiaxing University
2022-2023
Institute of Bioorganic Chemistry
2019-2023
Institute of Engineering Science and Metallurgy Far Eastern Branch of the Russian Academy of Sciences
2023
Pavlov Institute of Physiology of the Russian Academy of Sciences
2020
Gazprom (Russia)
2010
Southern Federal University
2001
Institute of Electrochemistry and Energy Systems
1988
Bulgarian Academy of Sciences
1988
Abstract Little is known about age‐dependent changes in structure and function of astrocytes the impact these on cognitive decline senescent brain. The prevalent view increase reactive astrogliosis astrocytic hypertrophy requires scrutiny detailed analysis. Using two‐photon microscopy conjunction with 3D reconstruction, Sholl volume fraction analysis, we demonstrate a significant reduction number length processes, territorial domains astrocyte‐to‐astrocyte coupling aged Probing physiology...
How aging affects cells of the human brain active milieu remains largely unknown. Here, we analyze astrocytes and neurons in neocortical tissue younger (22-50 years) older (51-72 adults. Aging decreases amount reduced mitochondrial cytochromes but not neurons. The protein-to-lipid ratio increases Aged show morphological atrophy quantified by decreased length branches, volume fraction leaflets, shrinkage anatomical domain. Atrophy correlates with loss gap junction coupling between increased...
Abstract Calorie-restricted (CR) diet has multiple beneficial effects on brain function. Here we report morphological and functional changes in hippocampal astrocytes 3-months-old mice subjected to 1 month of the diet. Whole-cell patch-clamp recordings were performed CA1 stratum (str.) radiatum slices. The cells also loaded with fluorescent dye through patch pipette. CR did not affect number astrocytic branches but increased volume fraction (VF) distal perisynaptic leaflets. astrocyte growth...
Abstract Aim A high‐fat diet (HFD) is generally considered to negatively influence the body, brain, and cognition. Nonetheless, fat fatty acids are essential for nourishing constructing brain tissue. Astrocytes central lipolysis metabolism. We tested how HFD affects astrocyte metabolism, morphology, physiology. Methods used Raman microspectroscopy assess redox state of mitochondria lipid content in astrocytes neurons hippocampal slices mice subjected HFD. were loaded with fluorescent dye...
Lypd6 is a GPI-tethered protein from the Ly-6/uPAR family expressed in brain. enhances Wnt/β-catenin signaling, although its action on nicotinic acetylcholine receptors (nAChRs) have been also proposed. To investigate cholinergic activity of Lypd6, we studied recombinant water-soluble variant human (ws-Lypd6) containing isolated “three-finger” LU-domain. Experiments at different nAChR subtypes Xenopus oocytes revealed negative allosteric modulatory ws-Lypd6. Ws-Lypd6 inhibited ACh-evoked...
Acid-sensing ion channels (ASICs) are proton-gated that mediate nociception in the peripheral nervous system and contribute to fear learning central system. Sevanol was reported previously as a naturally-occurring ASIC inhibitor from thyme with favorable analgesic anti-inflammatory activity. Using electrophysiological methods, we found high micromolar range, compound effectively inhibited homomeric ASIC1a and, sub- low-micromolar ranges, positively modulated currents of α1β2γ2 GABAA...
Transcutaneous stimulation is a neuromodulation method that efficiently used for recovery after spinal cord injury and other disorders are accompanied by motor sensory deficits. Multiple aspects of transcutaneous optimization still require testing in animal experiments including the use pharmacological agents, lesions, cell recording etc. This need initially motivated us to develop new approach transvertebral (SCS) test its feasibility acute chronic on rats. The aim current work was study...
Little is known about age-dependent changes in structure and function of astrocytes the impact these into cognitive decline senescent brain. The prevalent view on increase reactive astrogliosis astrocytic hypertrophy requires scrutiny detailed analysis. Using two-photon microscopy conjunction with 3D reconstruction, Sholl volume fraction analysis we demonstrate a significant reduction number length processes, territorial domains astrocyte-to-astrocyte coupling aged Probing physiology...
A complete and rigorous determination of the possible ground states for D-wave pairing Bose condensates is presented, using a geometrical invariant theory approach to problem. The order parameter argued be vector, transforming according ten dimensional real representation group $G=${\bf O}$_3\otimes${\bf U}$_1\times <{\cal T}>$. We determine equalities inequalities defining orbit space this linear its symmetry strata, which are in one-to-one correspondence with distinct phases system. find...
Abstract One month of calorically restricted diet (CR) induced morphological plasticity astrocytes in the stratum (str.) radiatum hippocampal CA1 three-months old mice: volume fraction distal perisynaptic astrocytic processes increased whereas number gap-junction coupled decreased. The uncoupling was not associated with a decrease expression connexin 43. Uncoupling and remodeling affected spontaneous Ca 2+ activity network: events became longer, their spread reduced. change pattern may...
Abstract How aging affects cellular components of the human brain active milieu remains largely unknown. We analyzed astrocytes and neurons in neocortical access tissue younger (22 - 50 years) older (51 72 adult patients who underwent glioma resection. Aging decreased amount reduced mitochondrial cytochromes but not neurons. The total protein was increased Aged showed morphological dystrophy quantified by length branches, volume fraction leaflets, shrinkage anatomical domain. Dystrophy...
We consider general model with factorization between macroscopic flow and matter decay distribution. show universality of $p_t^2$ behavior elliptic at small $p_t$ for identified final particles in the symmetric nucleus collision. At high we compare non-relativistic relativistic models boosted In distribution having power-like tail existence saturation. This means that value $v_2$ tend to constant $p_t$. discuss importance determination orientation which can help us different models. For...
A complete and rigorous determination of the possible ground states for D-wave pairing Bose condensates is presented. Using an orbit space approach to problem, we find 15 allowed phases (besides unbroken one), with different symmetries, that thoroughly determine, specifying group-subgroup relations between bordering phases.
Summary A high-fat diet (HFD) is generally considered to negatively influence the body, brain, and cognitive abilities. On other hand, fat fatty acids are essential for nourishing constructing brain tissue. Astrocytes central lipolysis metabolism. Here we show that exposure of young mice one month HFD elevates lipid content increases relative amount reduced cytochromes in astrocytes but not neurons. Metabolic changes were paralleled with an enlargement astrocytic territorial domains due...