A5045949251- Mitochondrial Function and Pathology
- Neuroscience and Neuropharmacology Research
- Diet and metabolism studies
- Neurogenesis and neuroplasticity mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Electrochemical sensors and biosensors
- Neuroinflammation and Neurodegeneration Mechanisms
- ATP Synthase and ATPases Research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Memory and Neural Mechanisms
- RNA Interference and Gene Delivery
- Health, Environment, Cognitive Aging
- MicroRNA in disease regulation
- Eicosanoids and Hypertension Pharmacology
- Sleep and Wakefulness Research
Institute of Bioorganic Chemistry
2021-2025
Lomonosov Moscow State University
2021-2025
Jiaxing University
2023-2024
Netherlands Institute for Neuroscience
2019
University of Amsterdam
2019
Abstract Aim A high‐fat diet (HFD) is generally considered to negatively influence the body, brain, and cognition. Nonetheless, fat fatty acids are essential for nourishing constructing brain tissue. Astrocytes central lipolysis metabolism. We tested how HFD affects astrocyte metabolism, morphology, physiology. Methods used Raman microspectroscopy assess redox state of mitochondria lipid content in astrocytes neurons hippocampal slices mice subjected HFD. were loaded with fluorescent dye...
Convulsive seizures promote adult hippocampal neurogenesis (AHN) through a transient activation of neural stem/progenitor cells (NSPCs) in the subgranular zone (SGZ) dentate gyrus (DG). However, significant population epilepsy patients, non-convulsive (ncSZ) are observed. The response NSPCs to seizure induction has not been characterized before. We here studied first short-term effects controlled on fate and identity. induced intensity by intrahippocampally injecting increasing doses...
The hemodynamic response links neural oxidative metabolism changes to increased cerebral blood flow during brain activity. Although Roy and Sherrington introduced this concept over a century ago (1890), the exact cellular mechanisms remain unclear. This study demonstrates how local supply increases correlate with metabolic of individual cells locomotion. Using Raman microspectroscopy, we observed an elevation in oxygen saturation levels (sO 2 ) cortical venules but not arterioles, which were...
Neuronal encoding of environmental information has long been in the focus neuroscience. Neurophysiological studies showed that neuronal activity changes specifically when animals become familiar with space or objects. However, despite a considerable amount experimental data, specific neural basis place and object remains an open question. The goal present study was to examine how hippocampus encodes about various types values objects at level individual neurons, also determine stability...
Summary A high-fat diet (HFD) is generally considered to negatively influence the body, brain, and cognitive abilities. On other hand, fat fatty acids are essential for nourishing constructing brain tissue. Astrocytes central lipolysis metabolism. Here we show that exposure of young mice one month HFD elevates lipid content increases relative amount reduced cytochromes in astrocytes but not neurons. Metabolic changes were paralleled with an enlargement astrocytic territorial domains due...