A5102753058- Nanoparticle-Based Drug Delivery
- Surfactants and Colloidal Systems
- Lipid Membrane Structure and Behavior
- Spectroscopy Techniques in Biomedical and Chemical Research
- RNA Interference and Gene Delivery
- Biotin and Related Studies
- Diatoms and Algae Research
- Protein Interaction Studies and Fluorescence Analysis
- Field-Flow Fractionation Techniques
- Gold and Silver Nanoparticles Synthesis and Applications
- Nanopore and Nanochannel Transport Studies
- Supramolecular Self-Assembly in Materials
- Click Chemistry and Applications
- Extracellular vesicles in disease
- Cancer Research and Treatment
- Liquid Crystal Research Advancements
- Protein purification and stability
- Heat shock proteins research
- Characterization and Applications of Magnetic Nanoparticles
- Polymer Surface Interaction Studies
- Viral Infections and Vectors
- Plasmonic and Surface Plasmon Research
- Electrochemical sensors and biosensors
- Bacteriophages and microbial interactions
- Monoclonal and Polyclonal Antibodies Research
P.N. Lebedev Physical Institute of the Russian Academy of Sciences
2024-2025
Institute of Bioorganic Chemistry
2024
National Research Nuclear University MEPhI
2021-2024
Institute of Bioorganic Chemistry
2019-2023
Moscow State Pedagogical University
2019
Introduction. Heat shock proteins (HSPs) are a group of highly prospective compounds that can be used in various branches clinical medicine, such as neurology, pharmacology and oncology. Studying the content these parts brain transgenic mice express increased concentrations exo- endogenous HSP will make it possible to clarify knowledge about their distribution structures central nervous system. The aim. To develop method for identifying analyzing heat weighing 70 kDa sections tissue using...
Despite the wide variety of available cationic lipid platforms for delivery nucleic acids into cells, optimization their composition has not lost its relevance. The purpose this work was to develop multi-component nanoparticles (LNPs) with or without a hydrophobic core from natural lipids in order evaluate efficiency LNPs widely used lipoid DOTAP (1,2-dioleoyloxy-3-[trimethylammonium]-propane) and previously unstudied oleoylcholine (Ol-Ch), as well ability containing GM3 gangliosides...
Abstract The synthetic function‐spacer‐lipid (FSL) amphiphile biotin‐CMG‐DOPE is widely used for delicate ligation of living cells with biotin residues under physiological conditions. Since this molecule has an “apolar‐polar‐hydrophobic” gemini structure, the supramolecular organization expected to differ significantly from classical micelle. Its investigated experimental methods and molecular dynamics simulations (MDS). Although linear length a single 9.5 nm, size dominant supramer globule...
Biomolecular corona is the major obstacle to clinical translation of nanomedicines. Since formation governed by molecular interactions at nano-bio interface, nanoparticle surface properties such as topography, charge and chemistry can be tuned manipulate biomolecular formation. To this end, first step towards a deep understanding processes formation, it necessary develop nanoparticles employing various biocompatible materials characterize their structure dynamics level. In work, we applied...
We investigated the presence of plasmon resonances (PRs) for substrates with metallic nanowires (NWs) that were obtained by matrix (template) synthesis method in pores track membranes. found experimentally location and width PRs depend on diameter NWs distance between them. The indicates potential applicability such as SERS-active substrates.
Biomolecular corona is the major obstacle in clinical translation of nanomedicines. To overcome this problem, comprehensive studies processes leading to formation a biomolecular are required. Since such dynamical require high spatial and temporal resolution, nanoparticles utilized it should enable combined experimental simulation studies. Interactions at nano-bio interface defined by nanoparticle surface properties as topography, charge chemistry. Hence, preliminary step towards deep...
Advances in nanotechnology recent decades have spread to medicine and led the emergence of nanotherapeutics that significantly increase efficiency reduce side effects drugs. One challenges this field is increasing solubility targeted delivery hydrophobic approach design nanoparticles for drugs loading use cyclodextrins, which are capable binding regions small molecules via host-guest interactions. However, rational drug carriers requires studying interactions between assessing effect bound...
Efficient site-specific drug delivery systems (DDS) would require sophisticated surface structure to overcome challenges arising from currently inevitable interactions with components of complex biological environment. One way endow nanoparticles (NPs) the designed properties is use excipients that enable appropriate multivalent modifications. In this respect, cyclodextrins (CDs) a versatile building block can be used provide NPs various modifications as well loading capacity by means...
Advances in nanotechnology have given rise to various biocompatible nanomaterials, that gained much attention biomedical research as delivery vehicles for diagnostic and therapeutic agents. Although nanoparticles(NPs) offer many advantages, the low vivo efficiency of existing nanocarriers is main obstacle their clinical translation. After exposure biological environment, NPs immediately interact with proteins form protein adsorption layer called corona, which alters physicochemical...
The Front Cover shows how a biotin residue initially hidden in monolayer formed on the surface of material by biot-CMG-DOPE is pulled out layer streptavidin molecule that has come close to it. This can be considered as model for living cell: sometimes molecules are able hide from undesirable interactions and yet leave possibility recognized high-affinity proteins. picture inspired legendary Yellow Submarine cartoon. More information found Full Paper Anton Zalygin al.
Abstract Invited for this month's cover is the group of Prof. Nicolai Bovin from Russian Academy Sciences. The picture shows how a biotin residue initially hidden in monolayer formed on surface material by biot‐CMG‐DOPE (see top left) pulled out layer streptavidin molecule (Str) that has come close to it below). This can be considered as model certain events (in particular, cis protein‐ligand interactions) occurring living cell when necessary hide ligand undesirable interactions, but leave...
Abstract Raman spectroscopy is a promising method for optical vibrational spectroscopy. Nowadays, finds many applications, in particular, biological and medical diagnostics. However, the scattering can be enhanced using Surface-enhanced method. Colloidal solutions of noble metals are used as SERS-active systems. In this work, enhancing factors were estimated colloidal silver three different types (citrate, borohydride, chloride) with two substances (phenylalanine, cytochrome C)....
Abstract Supramolecular self-assemble systems based on neoglycolipids: Galili-Ad-CMG 2 -Ad-DOPE, A(type2)-Ad-CMG -Ad-DOPE are studied here and compared with the well-studied Biotin-CMG as well their combinations NH2-CMG -Ad-DOPE. They function-spacer-lipid constructs unique structure that allows them to form micelle-like supramers be stable, what makes a potential drug nanocarriers. The structural properties of obtained supramolecular depending functional part, loading efficiency doxorubicin...
Abstract Neoglycolipids due to their amphiphilic properties exhibit self-assembly in aqueous phases. In high concentrations the liquid crystalline or gel phases may form. So-called soft-material are a subject of interest many scientists especially as biosensors and wound healing materials. this study we examine structure quasicrystalline phase biot-CMG(2)-DOPE obtained at concentration 150 mg/ml (13wt.%) PBS. The structural data such interplanar spacing, order parameter long-range were by...